PROACTING: predicting pathological complete response to neoadjuvant chemotherapy in breast cancer from routine diagnostic histopathology biopsies with deep learning

Autor: Witali Aswolinskiy, Enrico Munari, Hugo M. Horlings, Lennart Mulder, Giuseppe Bogina, Joyce Sanders, Yat-Hee Liu, Alexandra W. van den Belt-Dusebout, Leslie Tessier, Maschenka Balkenhol, Michelle Stegeman, Jeffrey Hoven, Jelle Wesseling, Jeroen van der Laak, Esther H. Lips, Francesco Ciompi

Publikováno v: Breast Cancer Research, Vol 25, Iss 1, Pp 1-15 (2023)

Abstract Background Invasive breast cancer patients are increasingly being treated with neoadjuvant chemotherapy; however, only a fraction of the patients respond to it completely. To prevent overtreatment, there is an urgent need for biomarkers to p

Externí odkaz: https://doaj.org/article/83850dbe69834722be710c67bd14b3d4

Genomic analysis defines clonal relationships of ductal carcinoma in situ and recurrent invasive breast cancer

Autor: Esther H, Lips, Tapsi, Kumar, Anargyros, Megalios, Lindy L, Visser, Michael, Sheinman, Angelo, Fortunato, Vandna, Shah, Marlous, Hoogstraat, Emi, Sei, Diego, Mallo, Maria, Roman-Escorza, Ahmed A, Ahmed, Mingchu, Xu, Alexandra W, van den Belt-Dusebout, Wim, Brugman, Anna K, Casasent, Karen, Clements, Helen R, Davies, Liping, Fu, Anita, Grigoriadis, Timothy M, Hardman, Lorraine M, King, Marielle, Krete, Petra, Kristel, Michiel, de Maaker, Carlo C, Maley, Jeffrey R, Marks, Brian A, Menegaz, Lennart, Mulder, Frank, Nieboer, Salpie, Nowinski, Sarah, Pinder, Jelmar, Quist, Carolina, Salinas-Souza, Michael, Schaapveld, Marjanka K, Schmidt, Abeer M, Shaaban, Rana, Shami, Mathini, Sridharan, John, Zhang, Hilary, Stobart, Deborah, Collyar, Serena, Nik-Zainal, Lodewyk F A, Wessels, E Shelley, Hwang, Nicholas E, Navin, P Andrew, Futreal, Alastair M, Thompson, Jelle, Wesseling, Marja, van Oirsouw

Publikováno v: Nature genetics. 54(6)

Ductal carcinoma in situ (DCIS) is the most common form of preinvasive breast cancer and, despite treatment, a small fraction (5-10%) of DCIS patients develop subsequent invasive disease. A fundamental biologic question is whether the invasive diseas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bc16e12a197d033dd3fbff69d2cda77f
https://pubmed.ncbi.nlm.nih.gov/35681052

Long-Term Risk of Ovarian Cancer and Borderline Tumors after Assisted Reproductive Technology

Autor: Ron J. T. van Golde, D.D.M. Braat, Mariëtte Goddijn, Frank J. M. Broekmans, Astrid E. P. Cantineau, G. M. Ouwens, Curt W. Burger, Lucette A. J. van der Westerlaken, Hester van Boven, Mandy Spaan, Miranda A. Gerritsma, Cornelis B. Lambalk, Michael Schaapveld, Jesper M. J. Smeenk, Paul A. M. Meeuwissen, Flora E. van Leeuwen, Minouche M.E. van Rumste, Alexandra W. van den Belt-Dusebout, Joop S.E. Laven, Roel Schats, Evert J.P. van Santbrink, Marian Kortman, Ben J. Cohlen, Carl J.C.M. Hamilton

Publikováno v: Spaan, M, van den Belt-Dusebout, A W, Lambalk, C B, van Boven, H H, Schats, R, Kortman, M, Broekmans, F J M, Laven, J S E, van Santbrink, E J P, Braat, D D M, van der Westerlaken, L A J, Cohlen, B J, Cantineau, A E P, Smeenk, J M J, van Rumste, M M, Goddijn, M, van Golde, R J T, Meeuwissen, P A M, Hamilton, C J C M, Ouwens, G M, Gerritsma, M A, Schaapveld, M, Burger, C W & van Leeuwen, F E 2021, ' Long-Term Risk of Ovarian Cancer and Borderline Tumors after Assisted Reproductive Technology ', Obstetrical and Gynecological Survey, vol. 76, no. 7, pp. 408-410 . https://doi.org/10.1093/jnci/djaa163, https://doi.org/10.1097/01.ogx.0000767232.06229.85
Obstetrical & Gynecological Survey, 76(7), 408-410. LIPPINCOTT WILLIAMS & WILKINS
Obstetrical and Gynecological Survey, 76(7), 408-410. Lippincott Williams & Wilkins
Obstetrical and Gynecological Survey, 76(7), 408-410. Lippincott Williams and Wilkins
Journal of the National Cancer Institute, 113, 6, pp. 699-709
J Natl Cancer Inst
Journal of the National Cancer Institute, 113(6), 699-709. Oxford University Press
Journal of the National Cancer Institute, 113, 699-709
Journal of the National Cancer Institute, 113(6):163, 699-709. Oxford University Press
JNCI: Journal of the National Cancer Institute, 113(6), 699-709. OXFORD UNIV PRESS INC

Despite inconclusive evidence, concerns that assisted reproductive technology may be associated with increased risk of ovarian cancer remain. Significant increases in gonadotropin levels and disruption of ovarian epithelium have been proposed as mech

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a226ff67dfa9c7196bbc41819e8cfddd
https://research.vumc.nl/en/publications/962b6f54-795c-440a-b7cd-ad7f9b00498f

Increased pancreatic cancer risk following radiotherapy for testicular cancer

Autor: Sophie D. Fosså, Eric J. Holowaty, Charles F. Lynch, Michael Andersson, Tom Børge Johannesen, Alexandra W. van den Belt-Dusebout, Joseph F. Fraumeni, Hans H. Storm, Flora E. van Leeuwen, Michael Hauptmann, Marilyn Stovall, Rita E. Weathers, Magnus Kaijser, Lindsay M. Morton, Ethel S. Gilbert, Per Hall, Lois B. Travis, Heikki Joensuu, Eero Pukkala, Berthe M.P. Aleman, Ruth A. Kleinerman, Rochelle E. Curtis, Preetha Rajaraman, Leila Vaalavirta, Susan A. Smith, Frøydis Langmark, Graça M. Dores

Publikováno v: British Journal of Cancer

Background: Pancreatic cancer risk is elevated among testicular cancer (TC) survivors. However, the roles of specific treatments are unclear. Methods: Among 23 982 5-year TC survivors diagnosed during 1947–1991, doses from radiotherapy to the pancr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d965c834bf705162d051d4db6b4cc51f
https://doi.org/10.1038/bjc.2016.272

Risk of diabetes after para-aortic radiation for testicular cancer

Autor: Peter De Brouwer, Ben G. L. Vanneste, Flora E. van Leeuwen, J. Martijn Kerst, Sjoukje Lubberts, Alphonsus C. M. van den Bergh, Tineke J. Smilde, J. Alfred Witjes, Jourik A. Gietema, Berthe M.P. Aleman, Maureen J.B. Aarts, O. W. M. Meijer, Maarten C.C.M. Hulshof, Gerard Groenewegen, Simon Horenblas, Ronald de Wit, Katarzina Jóźwiak, Michael Schaapveld, Luca Incrocci, Hetty A van den Berg, Harmke J. Groot, Alexandra W. van den Belt-Dusebout

Publikováno v: Groot, H J, Gietema, J A, Aleman, B M P, Incrocci, L, de Wit, R, Witjes, J A, Groenewegen, G, de Brouwer, P, Meijer, O W M, Hulshof, M C C M, van den Berg, H A, Smilde, T J, Vanneste, B G L, Aarts, M J, van den Bergh, A C M, Kerst, J M, van den Belt-Dusebout, A W, Lubberts, S, Jóźwiak, K, Horenblas, S, van Leeuwen, F E & Schaapveld, M 2018, ' Risk of diabetes after para-aortic radiation for testicular cancer ', British Journal of Cancer, vol. 119, no. 7, pp. 901-907 . https://doi.org/10.1038/s41416-018-0248-x
British Journal of Cancer, 119(7), 901-907. Nature Publishing Group
British journal of cancer, 119(7), 901-907. Nature Publishing Group
British Journal of Cancer, 119, 901-907
British Journal of Cancer
British Journal of Cancer, 119, 7, pp. 901-907

BACKGROUND: While the risk of diabetes is increased following radiation exposure to the pancreas among childhood cancer survivors, its association among testicular cancer (TC) survivors has not been investigated.METHODS: Diabetes risk was studied in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77e9f1b2251f1104f84fccbd45137d30
https://research.vumc.nl/en/publications/fbc13bdd-0cb2-436b-883c-a0a5c6311c9f