Zobrazeno 1 - 10
of 1 018
pro vyhledávání: '"A. W. Zimmerman"'
Publikováno v:
Frontiers in Nutrition, Vol 11 (2024)
Neuroinflammation in response to environmental stressors is an important common pathway in a number of neurological and psychiatric disorders. Responses to immune-mediated stress can lead to epigenetic changes and the development of neuropsychiatric
Externí odkaz:
https://doaj.org/article/150155abd75e40a1a2f5a58a5c44f667
Publikováno v:
iScience, Vol 27, Iss 8, Pp 110553- (2024)
Summary: This study models the geomechanical deformation of a depleted gas field, wherein gaseous hydrogen is stored in a North Sea reservoir, and is cyclically injected and withdrawn. A fault is modeled within the underburden, and its slip is invest
Externí odkaz:
https://doaj.org/article/60fefc3bcae54b73abdb7f1ff842cd4e
Autor:
Nina Weichert-Leahey, Hui Shi, Ting Tao, Derek A. Oldridge, Adam D. Durbin, Brian J. Abraham, Mark W. Zimmerman, Shizhen Zhu, Andrew C. Wood, Deepak Reyon, J. Keith Joung, Richard A. Young, Sharon J. Diskin, John M. Maris, A. Thomas Look
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 10 (2023)
Childhood neuroblastomas exhibit plasticity between an undifferentiated neural crest–like mesenchymal cell state and a more differentiated sympathetic adrenergic cell state. These cell states are governed by autoregulatory transcriptional loops cal
Externí odkaz:
https://doaj.org/article/26b30da61a8a4fd2905ae5306aa93199
Autor:
Yea Ji Jeong, Hildur Knutsdottir, Fatemeh Shojaeian, Michael G. Lerner, Maria F. Wissler, Elodie Henriet, Tammy Ng, Shalini Datta, Bernat Navarro-Serer, Peter Chianchiano, Benedict Kinny-Köster, Jacquelyn W. Zimmerman, Genevieve Stein-O’Brien, Matthias M. Gaida, James R. Eshleman, Ming-Tseh Lin, Elana J. Fertig, Andrew J. Ewald, Joel S. Bader, Laura D. Wood
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 8 (2023)
Pancreatic ductal adenocarcinoma (PDAC) frequently presents with metastasis, but the molecular programs in human PDAC cells that drive invasion are not well understood. Using an experimental pipeline enabling PDAC organoid isolation and collection ba
Externí odkaz:
https://doaj.org/article/877a49b959a144a8a641ca1dc42fec86
Autor:
Huan-Chang Liang, Mariantonia Costanza, Nicole Prutsch, Mark W. Zimmerman, Elisabeth Gurnhofer, Ivonne A. Montes-Mojarro, Brian J. Abraham, Nina Prokoph, Stefan Stoiber, Simone Tangermann, Cosimo Lobello, Jan Oppelt, Ioannis Anagnostopoulos, Thomas Hielscher, Shahid Pervez, Wolfram Klapper, Francesca Zammarchi, Daniel-Adriano Silva, K. Christopher Garcia, David Baker, Martin Janz, Nikolai Schleussner, Falko Fend, Šárka Pospíšilová, Andrea Janiková, Jacqueline Wallwitz, Dagmar Stoiber, Ingrid Simonitsch-Klupp, Lorenzo Cerroni, Stefano Pileri, Laurence de Leval, David Sibon, Virginie Fataccioli, Philippe Gaulard, Chalid Assaf, Fabian Knörr, Christine Damm-Welk, Wilhelm Woessmann, Suzanne D. Turner, A. Thomas Look, Stephan Mathas, Lukas Kenner, Olaf Merkel
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Anaplastic large cell lymphoma (ALCL) is an aggressive T-cell lymphoma often with poor prognosis. To identify genes defining ALCL cell state and dependencies, the authors here characterize ALCL-specific super-enhancers and describe the BATF3/IL-2R−
Externí odkaz:
https://doaj.org/article/6005c21ca6e84b989b1eb0469795a79b
Autor:
Andrew W. Zimmerman, Kanwaljit Singh, Susan L. Connors, Hua Liu, Anita A. Panjwani, Li-Ching Lee, Eileen Diggins, Ann Foley, Stepan Melnyk, Indrapal N. Singh, S. Jill James, Richard E. Frye, Jed W. Fahey
Publikováno v:
Molecular Autism, Vol 12, Iss 1, Pp 1-22 (2021)
Abstract Background Sulforaphane (SF), an isothiocyanate in broccoli, has potential benefits relevant to autism spectrum disorder (ASD) through its effects on several metabolic and immunologic pathways. Previous clinical trials of oral SF demonstrate
Externí odkaz:
https://doaj.org/article/cfdd1aa8a2284064ac4e1899d7e775ee
Publikováno v:
Journal of Rock Mechanics and Geotechnical Engineering, Vol 12, Iss 4, Pp 707-719 (2020)
The flow properties of geomechanically generated discrete fracture networks are examined in the context of channelling. Fracture networks are generated by growing fractures in tension, modelling the low permeability rock as a linear elastic material.
Externí odkaz:
https://doaj.org/article/756af3f047fe4851875fff152926067d
Autor:
Kanwaljit Singh, Indrapal N. Singh, Eileen Diggins, Susan L. Connors, Mohammad A. Karim, David Lee, Andrew W. Zimmerman, Richard E. Frye
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 7, Iss 5, Pp 683-694 (2020)
Abstract Background Developmental regression (DR) occurs in about one‐third of children with Autism Spectrum Disorder (ASD) yet it is poorly understood. Current evidence suggests that mitochondrial function in not normal in many children with ASD.
Externí odkaz:
https://doaj.org/article/fe5365ba68db4c09ad79eefadc691097
ASCL1 is a MYCN- and LMO1-dependent member of the adrenergic neuroblastoma core regulatory circuitry
Autor:
Lu Wang, Tze King Tan, Adam D. Durbin, Mark W. Zimmerman, Brian J. Abraham, Shi Hao Tan, Phuong Cao Thi Ngoc, Nina Weichert-Leahey, Koshi Akahane, Lee N. Lawton, Jo Lynne Rokita, John M. Maris, Richard A. Young, A. Thomas Look, Takaomi Sanda
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Polymorphisms in LMO1 are associated with increased susceptibility to develop neuroblastoma. Here, the authors show that LMO1 directly induces the transcription factor ASCL1, which regulates the differentiation of neurons, demonstrating that ASCL1 is
Externí odkaz:
https://doaj.org/article/e6eb4888c5884e66bc019c078ad386b1
Autor:
Hugo Jimenez, Minghui Wang, Jacquelyn W. Zimmerman, Michael J. Pennison, Sambad Sharma, Trevor Surratt, Zhi-Xiang Xu, Ivan Brezovich, Devin Absher, Richard M. Myers, Barry DeYoung, David L. Caudell, Dongquan Chen, Hui-Wen Lo, Hui-Kuan Lin, Dwayne W. Godwin, Michael Olivier, Anand Ghanekar, Kui Chen, Lance D. Miller, Yijian Gong, Myles Capstick, Ralph B. D'Agostino, Jr, Reginald Munden, Philippe Merle, Alexandre Barbault, Arthur W. Blackstock, Herbert L. Bonkovsky, Guang-Yu Yang, Guangxu Jin, Liang Liu, Wei Zhang, Kounosuke Watabe, Carl F. Blackman, Boris C. Pasche
Publikováno v:
EBioMedicine, Vol 44, Iss , Pp 209-224 (2019)
Background: Administration of amplitude modulated 27·12 MHz radiofrequency electromagnetic fields (AM RF EMF) by means of a spoon-shaped applicator placed on the patient's tongue is a newly approved treatment for advanced hepatocellular carcinoma (H
Externí odkaz:
https://doaj.org/article/e6da1a72d2b74e9ca9fe68b2f6f6a088