Zobrazeno 1 - 10
of 21
pro vyhledávání: '"A. W. Wotring"'
Publikováno v:
Journal of Dairy Science, Vol 105, Iss 4, Pp 2791-2802 (2022)
ABSTRACT: Bovine lactoferrin (bLF), a naturally occurring glycoprotein found in milk, has bioactive characteristics against many microbes, viruses, and other pathogens. Bovine lactoferrin strongly inhibits SARS-CoV-2 infection in vitro through direct
Externí odkaz:
https://doaj.org/article/2cf3be3932f645d3bfe53d1810bf2b96
Autor:
Wallace K. B. Chan, Keith M. Olson, Jesse W. Wotring, Jonathan Z. Sexton, Heather A. Carlson, John R. Traynor
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract The ongoing pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) requires treatments with rapid clinical translatability. Here we develop a multi-target and multi-ligand virtual screening method to identify FDA-app
Externí odkaz:
https://doaj.org/article/9d0a26fd74654609ba21d5d036893487
Autor:
Yuanyuan Qiao, Jesse W Wotring, Charles J Zhang, Xia Jiang, Lanbo Xiao, Andy Watt, Danielle Gattis, Eli Scandalis, Susan Freier, Yang Zheng, Carla D Pretto, Stephanie J Ellison, Eric E Swayze, Shuling Guo, Jonathan Z Sexton, Arul M Chinnaiyan
Publikováno v:
PLoS ONE, Vol 18, Iss 2, p e0281281 (2023)
Although the COVID-19 pandemic began over three years ago, the virus responsible for the disease, SARS-CoV-2, continues to infect people across the globe. As such, there remains a critical need for development of novel therapeutics against SARS-CoV-2
Externí odkaz:
https://doaj.org/article/b1383e6888f74bf2952f326be5d9d180
Autor:
Jesse W. Wotring, Sean M. McCarty, Khadija Shafiq, Charles J. Zhang, Theophilus Nguyen, Sophia R. Meyer, Reid Fursmidt, Carmen Mirabelli, Martin C. Clasby, Christiane E. Wobus, Matthew J. O’Meara, Jonathan Z. Sexton
Publikováno v:
Vaccines, Vol 10, Iss 8, p 1284 (2022)
Niclosamide, an FDA-approved oral anthelmintic drug, has broad biological activity including anticancer, antibacterial, and antiviral properties. Niclosamide has also been identified as a potent inhibitor of SARS-CoV-2 infection in vitro, generating
Externí odkaz:
https://doaj.org/article/487964f7eb2346369351c8a5aaae5f65
Autor:
Katura Metzner, Matthew J O’Meara, Benjamin Halligan, Jesse W. Wotring, Jonathan Z Sexton, Teresa R O’Meara
Publikováno v:
bioRxiv
Fungal pathogens likeCandida albicanscan cause devastating human disease. Treatment of candidemia is complicated by the high rate of resistance to common antifungal therapies. Additionally, there is host toxicity associated with many antifungal compo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dde5f1d5d15d4fbc290beb3ca9fb3601
https://europepmc.org/articles/PMC10153179/
https://europepmc.org/articles/PMC10153179/
Autor:
Jillian G. Hoffstadt, Jesse W. Wotring, Sam Porter, Benjamin Halligan, Matthew J. O’Meara, Andrew W. Tai, Jonathan Z. Sexton
Dengue Virus (DENV) causes dengue fever, a pandemic-potential disease with currently no FDA-approved antivirals. Additionally, the available vaccine for DENV can increase the risk of severe dengue fever for those who have never had a DENV infection d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93ec3d50f4a6b319197ad036a23ab2c8
https://doi.org/10.1101/2023.03.24.534108
https://doi.org/10.1101/2023.03.24.534108
Autor:
Roland D. Kersten, Lisa S. Mydy, Timothy R. Fallon, Floris de Waal, Khadija Shafiq, Jesse W. Wotring, Jonathan Z. Sexton, Jing-Ke Weng
Publikováno v:
Journal of the American Chemical Society. 144(17)
Moroidin is a bicyclic plant octapeptide with tryptophan side-chain cross-links, originally isolated as a pain-causing agent from the Australian stinging tree
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d48c02b6334b943bf2a194184f22e0b9
https://pubmed.ncbi.nlm.nih.gov/35438481
https://pubmed.ncbi.nlm.nih.gov/35438481
Publikováno v:
Journal of dairy science. 105(4)
Bovine lactoferrin (bLF), a naturally occurring glycoprotein found in milk, has bioactive characteristics against many microbes, viruses, and other pathogens. Bovine lactoferrin strongly inhibits SARS-CoV-2 infection in vitro through direct entry inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f537ef4b5d136837b2ce3835d21d8c9
https://pubmed.ncbi.nlm.nih.gov/35221061
https://pubmed.ncbi.nlm.nih.gov/35221061
Autor:
Floris de Waal, Jesse W Wotring, Lisa S. Mydy, Jonathan Z. Sexton, Osama G. Mohamed, Ashootosh Tripathi, Marnix H. Medema, Khadija Shafiq, Roland D. Kersten, Desnor N. Chigumba, Satria A. Kautsar, Wenjie Li, Tim Mladenovic
Publikováno v:
Nature Chemical Biology, 18(1), 18-28
Nature Chemical Biology 18 (2022) 1
Nature Chemical Biology 18 (2022) 1
Many bioactive plant cyclic peptides form side-chain-derived macrocycles. Lyciumins, cyclic plant peptides with tryptophan macrocyclizations, are ribosomal peptides (RiPPs) originating from repetitive core peptide motifs in precursor peptides with pl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c27433e7e8d855d3980a43254bf493c7
https://pubmed.ncbi.nlm.nih.gov/34811517
https://pubmed.ncbi.nlm.nih.gov/34811517
Autor:
Yi Yao, Kalpana Subedi, Jonathan Z. Sexton, Tingting Liu, Namir Khalasawi, Carla Pretto, Jesse W Wotring, Jie Wang, Congcong Yin, Aimin Jiang, Jia Li, Li Zhou, John McKinnon, Qing-Sheng Mi
Publikováno v:
The Journal of Immunology. 208:163.25-163.25
Angiotensin-converting enzyme 2 (ACE2) receptor is required for SARS-CoV-2 entry into human cells. However, emerging evidence shows SARS-CoV-2 infected lung monocytes/macrophages from COVID-19 patients barely express ACE2 mRNA, raising a question how
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d38d41cca532626bd8b6989a3d60df8b
https://doi.org/10.4049/jimmunol.208.supp.163.25
https://doi.org/10.4049/jimmunol.208.supp.163.25