Glucose metabolism controls monocyte homeostasis and migration but has no impact on atherosclerosis development in mice

Autor: Alexandre Gallerand, Bastien Dolfi, Marion I. Stunault, Zakariya Caillot, Alexia Castiglione, Axelle Strazzulla, Chuqiao Chen, Gyu Seong Heo, Hannah Luehmann, Flora Batoul, Nathalie Vaillant, Adélie Dumont, Thomas Pilot, Johanna Merlin, Fairouz N. Zair, Jerome Gilleron, Adeline Bertola, Peter Carmeliet, Jesse W. Williams, Rafael J. Arguello, David Masson, David Dombrowicz, Laurent Yvan-Charvet, Denis Doyen, Arvand Haschemi, Yongjian Liu, Rodolphe R. Guinamard, Stoyan Ivanov

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)

Abstract Monocytes directly contribute to atherosclerosis development by their recruitment to plaques in which they differentiate into macrophages. In the present study, we ask how modulating monocyte glucose metabolism could affect their homeostasis

Externí odkaz: https://doaj.org/article/75ff188150004c8a83111624efceb8a1

World of Crayfish™: a web platform towards real-time global mapping of freshwater crayfish and their pathogens

Autor: Mihaela C. Ion, Caitlin C. Bloomer, Tudor I. Bărăscu, Francisco J. Oficialdegui, Nathaniel F. Shoobs, Bronwyn W. Williams, Kevin Scheers, Miguel Clavero, Frédéric Grandjean, Marc Collas, Thomas Baudry, Zachary Loughman, Jeremy J. Wright, Timo J. Ruokonen, Christoph Chucholl, Simone Guareschi, Bram Koese, Zsombor M. Banyai, James Hodson, Margo Hurt, Katrin Kaldre, Boris Lipták, James W. Fetzner, Tommaso Cancellario, András Weiperth, Jạnis Birzaks, Teodora Trichkova, Milcho Todorov, Maksims Balalaikins, Bogna Griffin, Olga N. Petko, Ada Acevedo-Alonso, Guillermo D’Elía, Karolina Śliwińska, Anatoly Alekhnovich, Henry Choong, Josie South, Nick Whiterod, Katarina Zorić, Peter Haase, Ismael Soto, Daniel J. Brady, Phillip J. Haubrock, Pedro J. Torres, Denis Şadrin, Pavel Vlach, Cüneyt Kaya, Sang Woo Jung, Jin-Young Kim, Xavier H.C. Vermeersch, Maciej Bonk, Radu Guiaşu, Muzaffer M. Harlioğlu, Jane Devlin, Irmak Kurtul, Dagmara Błońska, Pieter Boets, Hossein Masigol, Paul R. Cabe, Japo Jussila, Trude Vrålstad, David V. Beresford, Scott M. Reid, Jiří Patoka, David A. Strand, Ali S. Tarkan, Frédérique Steen, Thomas Abeel, Matthew Harwood, Samuel Auer, Sandor Kelly, Ioannis A. Giantsis, Rafał Maciaszek, Maria V. Alvanou, Önder Aksu, David M. Hayes, Tadashi Kawai, Elena Tricarico, Adroit Chakandinakira, Zanethia C. Barnett, Ştefan G. Kudor, Andreea E. Beda, Lucian Vîlcea, Alexandru E. Mizeranschi, Marian Neagul, Anton Licz, Andra D. Cotoarbă, Adam Petrusek, Antonín Kouba, Christopher A. Taylor, Lucian Pârvulescu

Publikováno v: PeerJ, Vol 12, p e18229 (2024)

Freshwater crayfish are amongst the largest macroinvertebrates and play a keystone role in the ecosystems they occupy. Understanding the global distribution of these animals is often hindered due to a paucity of distributional data. Additionally, non

Externí odkaz: https://doaj.org/article/3f7985e4eb614ff08e77d8b3b373acc1

Cocaine regulates antiretroviral therapy CNS access through pregnane-x receptor-mediated drug transporter and metabolizing enzyme modulation at the blood brain barrier

Autor: Rodnie Colón Ortiz, Stephen Knerler, Lisa B. Fridman, Alicia Mercado, Amira-Storm Price, Jose J. Rosado-Franco, Hannah Wilkins, Bianca R. Flores, Benjamin C. Orsburn, Dionna W. Williams

Publikováno v: Fluids and Barriers of the CNS, Vol 21, Iss 1, Pp 1-27 (2024)

Abstract Background Appropriate interactions between antiretroviral therapies (ART) and drug transporters and metabolizing enzymes at the blood brain barrier (BBB) are critical to ensure adequate dosing of the brain to achieve HIV suppression. These

Externí odkaz: https://doaj.org/article/e4b502e6cecf445b9bae2fbc5aac1494

Influences of vaccination and public health strategies on COVID-19 dynamics in the United States: Evaluating policy impacts, behavioral responses, and variant proliferation

Autor: Jae Man Park, Seong Min Jo, Xiao Li, Vahed Maroufy, George W. Williams

Publikováno v: International Journal of One Health, Vol 9, Iss 2, Pp 172-180 (2023)

Background and Aim: The United States (US) government implemented interventions against COVID-19, but their effects on variant-related risks remain inconclusive. We aimed to assess the causal effects of vaccination rates, booster uptakes, face mask m

Externí odkaz: https://doaj.org/article/885ed00dd8a6480e83e4246dda5ad078

Transforming Home Dialysis Management of Patients with Advanced Kidney Disease Using an Intelligent Automated Application in Practice

Autor: Ziad M. Zoghby, MD, MBA, Andrea G. Kattah, MD, Kelsey Havlovic, MSN, RN, Dennis Stacy, MAN, RN, CNN, Margaret d’Uscio, APRN, CNP, DNP, Kirk P. Balderes, BS, John Seelman, BS, Karen F. Johnson, MA, John J. Dillon, MD, Alyssa Bishop, MBA, Jackie Vaughn, MA, Amy W. Williams, MD, Rajeev Chaudhry, MBBS, MPH

Publikováno v: Mayo Clinic Proceedings: Digital Health, Vol 1, Iss 3, Pp 258-266 (2023)

Objective: To describe the design, development, and deployment of an electronic health record (EHR)-based application to manage the Mayo Clinic home dialysis program, improve staff efficiency, and ensure delivery of high-quality clinical care. Patien

Externí odkaz: https://doaj.org/article/3c2acc555d3047198d2cfaa8a389914f