Výsledky vyhledávání - "A. W. Veenhuizen"

3,4-diarylpyrazoles: Potent and selective inhibitors of cyclooxygenase-2

Autor: Len F. Lee, Steven W. Kramer, A. W. Veenhuizen, Carol M. Koboldt, Paul W. Collins, Yan Y. Zhang, Peter C. Isakson, Karen Seibert, Thomas D. Penning

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 7:2121-2124

A series of 3,4-diarylpyrazoles was synthesized and evaluated for their ability to selectively inhibit cyclooxygenase-2 (COX-2). A number of potent and selective inhibitors were identified and found to have oral anti-inflammatory activity in a rat ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::479d32fe6815640e8bcff985c1ac75d3
https://doi.org/10.1016/s0960-894x(97)00372-7

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1,2-Diarylimidazoles as Potent, Cyclooxygenase-2 Selective, and Orally Active Antiinflammatory Agents

Autor: Yu Yi, Jacquelen J. Casler, Peter C. Isakson, Jaime L. Masferrer, Ish K. Khanna, Francis J. Koszyk, Paul W. Collins, Karen Seibert, Richard M. Weier, Yan Zhang, A. W. Veenhuizen, Carol M. Koboldt, Xiangdong Xu, William E. Perkins, S. A. Gregory

Publikováno v: Journal of Medicinal Chemistry. 40:1634-1647

Series of 1,2-diarylimidazoles has been synthesized and found to contain highly potent and selective inhibitors of the human COX-2 enzyme. The paper describes a short synthesis of the target 1,2-diarylimidazoles starting with aryl nitriles. Different

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c93724e239a9064506c442ec529d65fd
https://doi.org/10.1021/jm9700225

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1,2-Diarylpyrroles as Potent and Selective Inhibitors of Cyclooxygenase-2

Autor: Richard M. Weier, Julie M. Miyashiro, Karen Seibert, Jerry L. Currie, Paul W. Collins, Ish K. Khanna, A. W. Veenhuizen, Carol M. Koboldt, Peter C. Isakson, Yu Yi

Publikováno v: Journal of Medicinal Chemistry. 40:1619-1633

Series of 1,2-diarylpyrroles has been synthesized and found to contain very potent and selective inhibitors of the human cyclooxygenase-2 (COX-2) enzyme. The paper describes short and practical syntheses of the target molecules utilizing the Paal-Kno

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ae2f38b3e790d46f5eb64f1d1bd7a11
https://doi.org/10.1021/jm970036a

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Diarylspiro[2.4]heptenes as Orally Active, Highly Selective Cyclooxygenase-2 Inhibitors: Synthesis and Structure−Activity Relationships

Autor: Gary D. Anderson, A. W. Veenhuizen, Carol M. Koboldt, Karen Seibert, Robert E. Manning, William E. Perkins, Yan Zhang, Horng-Chi Huang, J. N. Cogburn, D. J. Garland, Jinglin Li, Emily J. Reinhard, David B. Reitz, S. A. Gregory, Timothy S. Chamberlain, E. G. Burton, Peter C. Isakson

Publikováno v: Journal of Medicinal Chemistry. 39:253-266

A novel series of 5,6-diarylspiro[2.4]hept-5-enes was shown to provide highly potent and selective cyclooxygenase-2 (COX-2) inhibitors. A study of structure-activity relationships in this series suggests that 3,4-disubstituted phenyl analogs are gene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c9ef2e75bc7cbe29bd4ca9744f026f5
https://doi.org/10.1021/jm950664x

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3,4-diarylthiophenes are selective COX-2 inhibitors

Autor: Graneto Matthew J, Donald J. Rogier, Yan Zhang, William E. Perkins, John J. Talley, Roland S. Rogers, Steven W. Kramer, A. W. Veenhuizen, Stephen R. Bertenshaw, Carol M. Koboldt, T. D. Penning

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 5:2919-2922

A group of 3,4-diarylthiophenes containing either a sulfone or sulfonamide moiety were synthesized and tested for COX-1 and COX-2 inhibition. They are selective inhibitors of COX-2 and possess antiinflammatory activity in vivo .

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::189fba94d4e196cef742bcb6f517780b
https://doi.org/10.1016/0960-894x(95)00512-r

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