Zobrazeno 1 - 10
of 443
pro vyhledávání: '"A. W. Shiver"'
Autor:
Hailong Guo, Sha Ha, Jason W. Botten, Kai Xu, Ningyan Zhang, Zhiqiang An, William R. Strohl, John W. Shiver, Tong-Ming Fu
Publikováno v:
Viruses, Vol 16, Iss 5, p 697 (2024)
Since the SARS-CoV-2 Omicron virus has gained dominance worldwide, its continual evolution with unpredictable mutations and patterns has revoked all authorized immunotherapeutics. Rapid viral evolution has also necessitated several rounds of vaccine
Externí odkaz:
https://doaj.org/article/9f434c9a18824f788d9203181f6e2477
Autor:
Hailong Guo, Bomsoo Cho, Paul R. Hinton, Sijia He, Yongjun Yu, Ashwin Kumar Ramesh, Jwala Priyadarsini Sivaccumar, Zhiqiang Ku, Kristen Campo, Sarah Holland, Sameer Sachdeva, Christopher Mensch, Mohamed Dawod, Annalis Whitaker, Philip Eisenhauer, Allison Falcone, Rebekah Honce, Jason W. Botten, Stephen F. Carroll, Bruce A. Keyt, Andrew W. Womack, William R. Strohl, Kai Xu, Ningyan Zhang, Zhiqiang An, Sha Ha, John W. Shiver, Tong-Ming Fu
Publikováno v:
Emerging Microbes and Infections, Vol 12, Iss 2 (2023)
The capacity of SARS-CoV-2 to evolve poses challenges to conventional prevention and treatment options such as vaccination and monoclonal antibodies, as they rely on viral receptor binding domain (RBD) sequences from previous strains. Additionally, a
Externí odkaz:
https://doaj.org/article/b32daa709614466280c100d037969216
Autor:
John W. Shiver, Celia C. LaBranche, Adonis A. Rubio, Joseph G. Joyce, Peter S. Kim, Benjamin N. Bell, David C. Montefiori, Maria V. Filsinger Interrante
Publikováno v:
Proc Natl Acad Sci U S A
The HIV-1 gp41 N-heptad repeat (NHR) region of the pre-hairpin intermediate, which is transiently exposed during HIV-1 viral membrane fusion, is a validated clinical target in humans and is inhibited by the FDA-approved drug enfuvirtide. However, vac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b998dc84333c9c0c25a70ec1749e380
https://doi.org/10.1073/pnas.2018027118
https://doi.org/10.1073/pnas.2018027118
Autor:
Fusheng Li, Adam C Finnefrock, Sheri A Dubey, Bette T M Korber, James Szinger, Suzanne Cole, M Juliana McElrath, John W Shiver, Danilo R Casimiro, Lawrence Corey, Steven G Self
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e20479 (2011)
T cell directed HIV vaccines are based upon the induction of CD8+ T cell memory responses that would be effective in inhibiting infection and subsequent replication of an infecting HIV-1 strain, a process that requires a match or near-match between t
Externí odkaz:
https://doaj.org/article/f5a5c2cd74964d488c8390d72ef137c1
Autor:
Gary J. Nabel, John W. Shiver
Publikováno v:
Nature. 565:29-31
Antibodies have been engineered to recognize diverse strains of influenza, including both the A and B types of virus that cause human epidemics. Are we moving closer to achieving ‘universal’ protection against all flu strains? An engineered antib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e9352a2029066ecb9c11c961bae3df3
https://doi.org/10.1038/d41586-018-07654-w
https://doi.org/10.1038/d41586-018-07654-w
Autor:
Kara S. Cox, Danilo R. Casimiro, Zhiqiang Zhang, Tong-Ming Fu, Amy S. Espeseth, Daniel C. Freed, Dai Wang, Yaping Liu, Adam C. Finnefrock, John W. Shiver, Suzanne Cole, Sheri Dubey, Muneeswara Babu Medi, Xi He, Liping Song, Fengsheng Li, Jingyuan Xu, Aimin Tang
Publikováno v:
Science translational medicine. 8(362)
Congenital human cytomegalovirus (HCMV) infection occurs in ~0.64% of infants born each year in the United States and is the leading nongenetic cause of childhood neurodevelopmental disabilities. No licensed HCMV vaccine is currently available. Natur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28d1cf15609b498c3ba0600d2fe6f82f
https://pubmed.ncbi.nlm.nih.gov/27797961
https://pubmed.ncbi.nlm.nih.gov/27797961
Autor:
Adam C. Finnefrock, Tong-Ming Fu, Sheri Dubey, Dai Wang, Suzanne Cole, Jan ter Meulen, Xi He, Daniel C. Freed, Danilo R. Casimiro, Aimin Tang, Fengsheng Li, John W. Shiver
Publikováno v:
Vaccine. 30:7469-7474
Maternal immunity to human cytomegalovirus (HCMV) prior to conception is ~70% protective against congenital transmission and in utero infection of HCMV. Both functional antibodies capable of neutralizing virus and effective T-cells are believed to be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fabe6a9b619b03817fa0d7d677811e80
https://doi.org/10.1016/j.vaccine.2012.10.053
https://doi.org/10.1016/j.vaccine.2012.10.053
Autor:
Michael Piatak, David B. Allison, Jeffrey D. Lifson, Andrea M. Weiler, Shari M. Piaskowski, Andrew J. Bett, Henry T. Robertson, Matthew R. Reynolds, Danilo R. Casimiro, Wayne C. Koff, John W. Shiver, David I. Watkins, Nancy A. Wilson
Publikováno v:
Vaccine. 30:4465-4475
It has been suggested that poor immunogenicity may explain the lack of vaccine efficacy in preventing or controlling HIV infection in the Step trial. To investigate this issue we vaccinated eight Indian rhesus macaques with a trivalent replication-in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d02c2d8ae8f272f930109bd9cfc35c3
https://doi.org/10.1016/j.vaccine.2012.04.082
https://doi.org/10.1016/j.vaccine.2012.04.082
Autor:
Michael B. McChesney, Michael A. Thomas, John W. Shiver, Huma Qureshi, Peter B. Gilbert, Zhong-Min Ma, Danilo R. Casimiro, Linda Fritts, Andrew J. Bett, Ying Huang, Christopher J. Miller, Veronique Desilva, Janet DiPasquale, Marjorie Robert-Guroff, Gregory Hodge, Michael N. Robertson
Publikováno v:
Journal of Virology. 86:2239-2250
The Step Trial showed that the MRKAd5 HIV-1 subtype B Gag/Pol/Nef vaccine did not protect men from HIV infection or reduce setpoint plasma viral RNA (vRNA) levels but, unexpectedly, it did modestly enhance susceptibility to HIV infection in adenoviru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6acec2a6d94d23470ba4ef8e6fd977e9
https://doi.org/10.1128/jvi.06175-11
https://doi.org/10.1128/jvi.06175-11
Autor:
Lani Indrawati, John W. Shiver, John E. Macnair, Jon H. Heinrichs, Michael P. Caulfield, Julie M. Skinner, Narahari S. Pujar, Michael A. Winters, Jayme L. Cannon, Walter E. Manger, Yuhua Zhang, Jeffrey T. Blue, Joseph M. Antonello
Publikováno v:
Vaccine. 29:8870-8876
The incidence of invasive pneumococcal disease (IPD), caused by the approximately 91 serotypes of Streptococcus pneumoniae (PN), varies geographically and temporally as a result of changing epidemiology and vaccination patterns as well as due to regi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10df316e4f9b3a8d944f6148efaf9f83
https://doi.org/10.1016/j.vaccine.2011.09.078
https://doi.org/10.1016/j.vaccine.2011.09.078