Zobrazeno 1 - 10
of 173
pro vyhledávání: '"A. W. Saville"'
Autor:
Dhiraj Mannar, James W. Saville, Chad Poloni, Xing Zhu, Alison Bezeruk, Keith Tidey, Sana Ahmed, Katharine S. Tuttle, Faezeh Vahdatihassani, Spencer Cholak, Laura Cook, Theodore S. Steiner, Sriram Subramaniam
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract The XBB.1.5 variant of SARS-CoV-2 has rapidly achieved global dominance and exhibits a high growth advantage over previous variants. Preliminary reports suggest that the success of XBB.1.5 stems from mutations within its spike glycoprotein,
Externí odkaz:
https://doaj.org/article/ae5378a14a484288800e9c8db99f2846
Autor:
Dhiraj Mannar, James W. Saville, Zehua Sun, Xing Zhu, Michelle M. Marti, Shanti S. Srivastava, Alison M. Berezuk, Steven Zhou, Katharine S. Tuttle, Michele D. Sobolewski, Andrew Kim, Benjamin R. Treat, Priscila Mayrelle Da Silva Castanha, Jana L. Jacobs, Simon M. Barratt-Boyes, John W. Mellors, Dimiter S. Dimitrov, Wei Li, Sriram Subramaniam
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
SARS-CoV-2 variants have accumulated multiple defining mutations within their spike glycoproteins. Here, the authors report a structural basis for broad neutralization of several variants by a heavy chain antibody fragment and provide a mutational an
Externí odkaz:
https://doaj.org/article/8507bc9f2a6c4b9e85210fb73299d3d4
Autor:
James W. Saville, Dhiraj Mannar, Xing Zhu, Shanti S. Srivastava, Alison M. Berezuk, Jean-Philippe Demers, Steven Zhou, Katharine S. Tuttle, Inna Sekirov, Andrew Kim, Wei Li, Dimiter S. Dimitrov, Sriram Subramaniam
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Saville, Mannar et al. provide a structural basis for enhanced antibody evasion and ACE2 binding by the Delta SARS-CoV-2 spike protein. They further identify a head-to-head dimer-of-trimers cryoEM reconstruction unique to the Kappa variant spike.
Externí odkaz:
https://doaj.org/article/feef3d51eb6145eeb9cb3f29799a3060
Autor:
James W. Saville, Dhiraj Mannar, Xing Zhu, Alison M. Berezuk, Spencer Cholak, Katherine S. Tuttle, Faezeh Vahdatihassani, Sriram Subramaniam
Publikováno v:
Cell Reports, Vol 42, Iss 1, Pp 111964- (2023)
Summary: The BA.2 sub-lineage of the Omicron (B.1.1.529) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant rapidly supplanted the original BA.1 sub-lineage in early 2022. Both lineages threatened the efficacy of vaccine-elicited an
Externí odkaz:
https://doaj.org/article/5cc9cd2362a4409b9f1c350194feca06
Autor:
Chuan Chen, James W. Saville, Michelle M. Marti, Alexandra Schäfer, Mary Hongying Cheng, Dhiraj Mannar, Xing Zhu, Alison M. Berezuk, Anupam Banerjee, Michele D. Sobolewski, Andrew Kim, Benjamin R. Treat, Priscila Mayrelle Da Silva Castanha, Nathan Enick, Kevin D. McCormick, Xianglei Liu, Cynthia Adams, Margaret Grace Hines, Zehua Sun, Weizao Chen, Jana L. Jacobs, Simon M. Barratt-Boyes, John W. Mellors, Ralph S. Baric, Ivet Bahar, Dimiter S. Dimitrov, Sriram Subramaniam, David R. Martinez, Wei Li
Publikováno v:
iScience, Vol 25, Iss 8, Pp 104798- (2022)
Summary: The emergence of SARS-CoV-2 variants of concern (VOCs) requires the development of next-generation biologics with high neutralization breadth. Here, we characterized a human VH domain, F6, which we generated by sequentially panning large pha
Externí odkaz:
https://doaj.org/article/e9a8e86720ca420e9915a6296aa53a18
Autor:
Xing Zhu, Dhiraj Mannar, Shanti S Srivastava, Alison M Berezuk, Jean-Philippe Demers, James W Saville, Karoline Leopold, Wei Li, Dimiter S Dimitrov, Katharine S Tuttle, Steven Zhou, Sagar Chittori, Sriram Subramaniam
Publikováno v:
PLoS Biology, Vol 19, Iss 4, p e3001237 (2021)
The recently reported "UK variant" (B.1.1.7) of SARS-CoV-2 is thought to be more infectious than previously circulating strains as a result of several changes, including the N501Y mutation. We present a 2.9-Å resolution cryo-electron microscopy (cry
Externí odkaz:
https://doaj.org/article/3c1f36e42d5749cfa2e5fb28488e1f6f
Autor:
Alison W. Saville, Dennis Gurfinkel, Brenda L. Beaty, Alison E. Chi, Amanda Dayton, Laura Hurley, Krithika Suresh, Allison Kempe
Publikováno v:
Preventive Medicine Reports, Vol 21, Iss , Pp 101296- (2021)
Little is known about Immunization Information System (IIS) attitudes and experiences using Centralized IIS-based Reminder/Recall (CI-R/R), an effective approach to increasing immunization rates.To describe among IIS managers as it relates to CI-R/R:
Externí odkaz:
https://doaj.org/article/5555dbcb0c6e47eaab59f805add421b8
Autor:
Spencer Cholak, James W. Saville, Xing Zhu, Alison M. Berezuk, Katharine S. Tuttle, Omid Haji-Ghassemi, Francisco J. Alvarado, Filip Van Petegem, Sriram Subramaniam
Publikováno v:
Structure.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2441eed6db49fd9675419c5c7aa98b3f
https://doi.org/10.1016/j.str.2023.04.009
https://doi.org/10.1016/j.str.2023.04.009
Autor:
Dhiraj Mannar, James W. Saville, Xing Zhu, Shanti S. Srivastava, Alison M. Berezuk, Katharine S. Tuttle, Ana Citlali Marquez, Inna Sekirov, Sriram Subramaniam
Publikováno v:
Science. 375:760-764
The newly reported Omicron variant is poised to replace Delta as the most prevalent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant across the world. Cryo–electron microscopy (cryo-EM) structural analysis of the Omicron variant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09faa4a1613c55d84f2d3b0b462f0f5d
https://doi.org/10.1126/science.abn7760
https://doi.org/10.1126/science.abn7760
Autor:
James W. Saville, Joseph A. Ross, Tyler Trefz, Crystal Schatz, Heather Matheson-Bird, Brenda Ralston, Ori Granot, Karin Schmid, Richard Terry, Nicholas D. Allan, Jeremy E. Wulff, Merle Olson
Publikováno v:
Animals, Vol 10, Iss 12, p 2363 (2020)
Castration is among the most common management procedures performed in the dairy and beef cattle industries and is mainly performed by surgery or elastic banding. Despite the various benefits of castration, all methods produce pain and distress. Cast
Externí odkaz:
https://doaj.org/article/35914aa1fe654386a78233d40dc2fb6e