Zobrazeno 1 - 10
of 1 682
pro vyhledávání: '"A. W. Sanders"'
Autor:
Steven W. de Taeye, Angela I. Schriek, Jeffrey C. Umotoy, Marloes Grobben, Judith A. Burger, Rogier W. Sanders, Gestur Vidarsson, Manfred Wuhrer, David Falck, Neeltje A. Kootstra, Marit J. van Gils
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-11 (2024)
Abstract Broadly neutralizing antibodies (bNAbs) targeting the HIV-1 envelope glycoprotein (Env) have the capacity to delay viral rebound when administered to people with HIV-1 (PWH) during anti-retroviral therapy (ART) interruption. To further enhan
Externí odkaz:
https://doaj.org/article/bd55cd58e2634a59b51fc88dc6c76b5f
Autor:
Denise Guerra, Laura Radić, Mitch Brinkkemper, Meliawati Poniman, Lara van der Maas, Jonathan L. Torres, Andrew B. Ward, Kwinten Sliepen, Janke Schinkel, Rogier W. Sanders, Marit J. van Gils, Tim Beaumont
Publikováno v:
Human Vaccines & Immunotherapeutics, Vol 20, Iss 1 (2024)
Monoclonal neutralizing antibodies (mAbs) are considered an important prophylactic against SARS-CoV-2 infection in at-risk populations and a strategy to counteract future sarbecovirus-induced disease. However, most mAbs isolated so far neutralize onl
Externí odkaz:
https://doaj.org/article/1fbcc6e3d1d94ac096e091f76a23bb0a
Autor:
Annemart Koornneef, Kanika Vanshylla, Gijs Hardenberg, Lucy Rutten, Nika M. Strokappe, Jeroen Tolboom, Jessica Vreugdenhil, Karin Feddes-de Boer, Aditya Perkasa, Sven Blokland, Judith A. Burger, Wei-Chiao Huang, Jonathan F. Lovell, Danielle van Manen, Rogier W. Sanders, Roland C. Zahn, Hanneke Schuitemaker, Johannes P. M. Langedijk, Frank Wegmann
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract One of the strategies towards an effective HIV-1 vaccine is to elicit broadly neutralizing antibody responses that target the high HIV-1 Env diversity. Here, we present an HIV-1 vaccine candidate that consists of cobalt porphyrin-phospholipi
Externí odkaz:
https://doaj.org/article/b47f9ae471c641c184638edf81cb1133
Autor:
Iván del Moral-Sánchez, Edmund G. Wee, Yuejiao Xian, Wen-Hsin Lee, Joel D. Allen, Alba Torrents de la Peña, Rebeca Fróes Rocha, James Ferguson, André N. León, Sylvie Koekkoek, Edith E. Schermer, Judith A. Burger, Sanjeev Kumar, Robby Zwolsman, Mitch Brinkkemper, Aafke Aartse, Dirk Eggink, Julianna Han, Meng Yuan, Max Crispin, Gabriel Ozorowski, Andrew B. Ward, Ian A. Wilson, Tomáš Hanke, Kwinten Sliepen, Rogier W. Sanders
Publikováno v:
npj Vaccines, Vol 9, Iss 1, Pp 1-18 (2024)
Abstract Recombinant native-like HIV-1 envelope glycoprotein (Env) trimers are used in candidate vaccines aimed at inducing broadly neutralizing antibodies. While state-of-the-art SOSIP or single-chain Env designs can be expressed as native-like trim
Externí odkaz:
https://doaj.org/article/9406da7e97304295838f177acd6e13b0
Publikováno v:
JMIR Public Health and Surveillance, Vol 10, Pp e56571-e56571 (2024)
Abstract BackgroundThe COVID-19 pandemic resulted in a massive disruption in access to care and thus passive, hospital- and clinic-based surveillance programs. In 2020, the reported cases of Lyme disease were the lowest both across the United States
Externí odkaz:
https://doaj.org/article/eedb9db25fab46b98c8e161c41565201
Autor:
Philip J.M. Brouwer, Hailee R. Perrett, Tim Beaumont, Haye Nijhuis, Sabine Kruijer, Judith A. Burger, Ilja Bontjer, Wen-Hsin Lee, James A. Ferguson, Martin Schauflinger, Helena Müller-Kräuter, Rogier W. Sanders, Thomas Strecker, Marit J. van Gils, Andrew B. Ward
Publikováno v:
Cell Reports, Vol 43, Iss 9, Pp 114708- (2024)
Summary: Lassa fever continues to be a major public health burden in West Africa, yet effective therapies or vaccines are lacking. The isolation of protective neutralizing antibodies against the Lassa virus glycoprotein complex (GPC) justifies the de
Externí odkaz:
https://doaj.org/article/6024a95cb789487bbd0a23b8611ae42e
Autor:
Alan J. Sosa, Michael K. Rooney, Howard D. Thames, Jeremiah W. Sanders, David M. Swanson, Seungtaek L. Choi, Quynh-Nhu Nguyen, Henry Mok, Deborah A. Kuban, X. Ron Zhu, Shalin Shah, Lauren L. Mayo, Karen E. Hoffman, Chad Tang, Sean E. McGuire, Narayan Sahoo, Xiaodong Zhang, Andrew K. Lee, Thomas J. Pugh, Usama Mahmood, John W. Davis, Brian F. Chapin, Paul Corn, Reena Kudchadker, Noveen Ausat, Steven J. Frank
Publikováno v:
Clinical and Translational Radiation Oncology, Vol 48, Iss , Pp 100822- (2024)
Background: Proton therapy (PT) has unique biologic properties with excellent clinical outcomes for the management of localized prostate cancer. Here, we aim to characterize the toxicity of PT for patients with localized prostate cancer and propose m
Externí odkaz:
https://doaj.org/article/91f77869f0f94ffda164c4d00a789e7e
Autor:
Karlijn van der Straten, Denise Guerra, Gius Kerster, Mathieu Claireaux, Marloes Grobben, Angela I Schriek, Anders Boyd, Jacqueline van Rijswijk, Khadija Tejjani, Dirk Eggink, Tim Beaumont, Steven W de Taeye, Godelieve J de Bree, Rogier W Sanders, Marit J van Gils
Publikováno v:
PLoS Pathogens, Vol 20, Iss 8, p e1012453 (2024)
Neutralization of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) by human sera is a strong correlate of protection against symptomatic and severe Coronavirus Disease 2019 (COVID-19). The emergence of antigenically distinct SARS-CoV-2 va
Externí odkaz:
https://doaj.org/article/0bf61c3096a54740ab2bb2dd50612712
Autor:
Sam Daly, João Ferreira Fernandes, Ezra Bruggeman, Anoushka Handa, Ruby Peters, Sarah Benaissa, Boya Zhang, Joseph S. Beckwith, Edward W. Sanders, Ruth R. Sims, David Klenerman, Simon J. Davis, Kevin O’Holleran, Steven F. Lee
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract Volumetric super-resolution microscopy typically encodes the 3D position of single-molecule fluorescence into a 2D image by changing the shape of the point spread function (PSF) as a function of depth. However, the resulting large and comple
Externí odkaz:
https://doaj.org/article/c36760769e7f4f429745b5a08a5a2651
Autor:
Mitch Brinkkemper, Meliawati Poniman, Esther Siteur-van Rijnstra, Widad Ait Iddouch, Tom P.L. Bijl, Denise Guerra, Khadija Tejjani, Marloes Grobben, Farien Bhoelan, Denzel Bemelman, Ronald Kempers, Marit J. van Gils, Kwinten Sliepen, Toon Stegmann, Yme U. van der Velden, Rogier W. Sanders
Publikováno v:
iScience, Vol 27, Iss 5, Pp 109719- (2024)
Summary: Zoonotic events by sarbecoviruses have sparked an epidemic (severe acute respiratory syndrome coronavirus [SARS-CoV]) and a pandemic (SARS-CoV-2) in the past two decades. The continued risk of spillovers from animals to humans is an ongoing
Externí odkaz:
https://doaj.org/article/d7e94e034de54733ba21aac6f170e6e9