Zobrazeno 1 - 10
of 781
pro vyhledávání: '"A. W. Irwin"'
Autor:
I. Whitehead, G. W. Irwin, F. Bannon, C. E. Coles, E. Copson, R. I. Cutress, R. V. Dave, M. D. Gardiner, M. Grayson, C. Holcombe, S. Irshad, C. O’Brien, R. L. O’Connell, C. Palmieri, A. M. Shaaban, N. Sharma, J. K. Singh, S. Potter, S. A. McIntosh, on behalf of the NeST Study Research Collaborative
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-9 (2021)
Abstract Background Neoadjuvant systemic therapy (NST) is increasingly used in the treatment of breast cancer, yet it is clear that there is significant geographical variation in its use in the UK. This study aimed to examine stated practice across U
Externí odkaz:
https://doaj.org/article/3196506ac10e4a249fd5b755392b4528
Autor:
Paul B. Mullan, Victoria Bingham, Paula Haddock, Gareth W. Irwin, Elaine Kay, Stephen McQuaid, Niamh E. Buckley
Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-13 (2019)
Abstract Background Triple Negative breast cancer (TNBC) is a poor outcome subgroup of breast cancer defined based on the absence of expression of ERα and PR and HER2 amplification. These hard to treat cancers lack targeted treatment options and are
Externí odkaz:
https://doaj.org/article/4531eab64b0f409585612c4bdac7b40f
Autor:
Barry V. W. Irwin, Franco Loyola
Publikováno v:
International Conference on Intelligent and Innovative Computing Applications. 2022:13-21
This research explains both why logging is useful and why the integrity of logs and the logging process is important. This is followed by a discussion of the design and implementation of a high-performance secure logging framework, implemented in Gol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a6b3cbfe17f73f1b2c749d38d050097
https://doi.org/10.59200/iconic.2022.002
https://doi.org/10.59200/iconic.2022.002
Autor:
Guangqi Ouyang, Amir Hanna, Samatha Benedict, Goutham Ezhilarasu, Arsalan Alam, Randall W. Irwin, Subramanian S. Iyer
Publikováno v:
IEEE Transactions on Components, Packaging and Manufacturing Technology. 12:1692-1701
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14ad4119c88cc018a756bbf003b35d6a
https://doi.org/10.1109/tcpmt.2022.3207031
https://doi.org/10.1109/tcpmt.2022.3207031
Autor:
Kienan I. Savage, Grant S. Stewart, D. Paul Harkin, Ken I. Mills, Melissa J. La Bonte, Cheryl Latimer, Fabio G. Liberante, Hayley McMillan, Gareth W. Irwin, Satpal S. Jhujh, Eliana M. Barros, Katrina M. Lappin
Supplementary Data from Cancer-Associated SF3B1 Mutations Confer a BRCA-Like Cellular Phenotype and Synthetic Lethality to PARP Inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10e250212f00f5cee0275162a86dd3d0
https://doi.org/10.1158/0008-5472.22430763
https://doi.org/10.1158/0008-5472.22430763
Autor:
Kienan I. Savage, Grant S. Stewart, D. Paul Harkin, Ken I. Mills, Melissa J. La Bonte, Cheryl Latimer, Fabio G. Liberante, Hayley McMillan, Gareth W. Irwin, Satpal S. Jhujh, Eliana M. Barros, Katrina M. Lappin
Mutations in SF3B1 have been identified across several cancer types. This key spliceosome component promotes the efficient mRNA splicing of thousands of genes including those with crucial roles in the cellular response to DNA damage. Here, we demonst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::364cc5b93440e42b205c4d417aa934cb
https://doi.org/10.1158/0008-5472.c.6513714.v1
https://doi.org/10.1158/0008-5472.c.6513714.v1
Autor:
Kienan I. Savage, Grant S. Stewart, D. Paul Harkin, Ken I. Mills, Melissa J. La Bonte, Cheryl Latimer, Fabio G. Liberante, Hayley McMillan, Gareth W. Irwin, Satpal S. Jhujh, Eliana M. Barros, Katrina M. Lappin
Supplementary Table from Cancer-Associated SF3B1 Mutations Confer a BRCA-Like Cellular Phenotype and Synthetic Lethality to PARP Inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae8b72cb731bca85602ae22e3e680e94
https://doi.org/10.1158/0008-5472.22430757
https://doi.org/10.1158/0008-5472.22430757
Autor:
D. Paul Harkin, Christopher T. Elliott, Derek J. Richard, Manuel Salto-Tellez, Stuart A. McIntosh, Kevin M. Prise, Ben Ho Park, Simon S. McDade, Lorenzo Manti, Alexander Powell, Angelina F. Madden, Joy N. Kavanagh, Jekaterina Vohhodina, Katy S. Orr, Julia J. Gorski, Gareth W. Irwin, Kevin M. Cooper, Eliana M. Barros, Kyle B. Matchett, Kienan I. Savage
PDF file - 2823K, Supplementary Figure 1. Estrogen metabolites cause DNA double strand breaks in S- phase cells. Supplementary Figure 2. BRCA1 supresses estrogen metabolite mediated DSBs and is required for their repair. Supplementary Figure 3. Estro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6645350cb792a59baf4945077f274e6b
https://doi.org/10.1158/0008-5472.22398495.v1
https://doi.org/10.1158/0008-5472.22398495.v1
Autor:
D. Paul Harkin, Christopher T. Elliott, Derek J. Richard, Manuel Salto-Tellez, Stuart A. McIntosh, Kevin M. Prise, Ben Ho Park, Simon S. McDade, Lorenzo Manti, Alexander Powell, Angelina F. Madden, Joy N. Kavanagh, Jekaterina Vohhodina, Katy S. Orr, Julia J. Gorski, Gareth W. Irwin, Kevin M. Cooper, Eliana M. Barros, Kyle B. Matchett, Kienan I. Savage
PDF file - 124K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a4ae762607366d5bfe72bdf21791e6a
https://doi.org/10.1158/0008-5472.22398492.v1
https://doi.org/10.1158/0008-5472.22398492.v1
Autor:
D. Paul Harkin, Christopher T. Elliott, Derek J. Richard, Manuel Salto-Tellez, Stuart A. McIntosh, Kevin M. Prise, Ben Ho Park, Simon S. McDade, Lorenzo Manti, Alexander Powell, Angelina F. Madden, Joy N. Kavanagh, Jekaterina Vohhodina, Katy S. Orr, Julia J. Gorski, Gareth W. Irwin, Kevin M. Cooper, Eliana M. Barros, Kyle B. Matchett, Kienan I. Savage
Germline mutations in BRCA1 predispose carriers to a high incidence of breast and ovarian cancers. BRCA1 functions to maintain genomic stability through critical roles in DNA repair, cell-cycle arrest, and transcriptional control. A major question ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d67877f1b4216097f9c5983ff040523
https://doi.org/10.1158/0008-5472.c.6505080.v1
https://doi.org/10.1158/0008-5472.c.6505080.v1