Výsledky vyhledávání - "A. W. Chucholowski"

ChemInform Abstract: Inhibitors of Cholesterol Biosynthesis. Part 3. Tetrahydro-4-hydroxy-6- (2-(1H-pyrrol-1-yl)ethyl)-2H-pyran-2-one Inhibitors of HMG-CoA Reductase. Part 2. Effects of Introducing Substituents at Positions Three and Four of the Pyrrole N

Autor: Bruce D. Roth, Milton L. Hoefle, A. W. Chucholowski, Roger S. Newton, C. D. Stratton, C. J. Blankley, Daniel F. Ortwine, Michael W. Wilson, C. S. Sekerke, E. Ferguson, Drago Robert Sliskovic

Publikováno v: ChemInform. 22

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::95f00d21dc7c50c00a330f1286965802
https://doi.org/10.1002/chin.199124136

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ChemInform Abstract: Base-Catalyzed Rearrangement of 5-Cyanomethyl-2-isoxazolines (I). Novel Pathway for the Formation of 2-Aminopyridine N-Oxides (II)

Autor: Susan E. Uhlendorf, A. W. Chucholowski

Publikováno v: ChemInform. 22

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2c4adf8e35d85212f267acfc4e99ae27
https://doi.org/10.1002/chin.199104221

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ChemInform Abstract: Heterocyclic Ureas: Inhibitors of Acyl-CoA:Cholesterol O- Acyltransferase (ACAT) as Hypocholesterolemic Agents

Autor: Brian R. Krause, M. A. Dominick, M. Neub, Michael W. Wilson, C. J. Blankley, Andrew D. White, A. W. Chucholowski, K. L. Hamelehle, Mark Wallace Creswell, R. F. Bousley, A. D. Essenburg, R. L. Stanfield

Publikováno v: ChemInform. 28

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3ce295a3b95ed9b00b07cb1e44d73d66
https://doi.org/10.1002/chin.199707147

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Relationship between tissue selectivity and lipophilicity for inhibitors of HMG-CoA reductase

Autor: C. J. Blankley, P. L. Creger, Thomas M.A. Bocan, E. Ferguson, Mark Wallace Creswell, Bruce D. Roth, J. A. Picard, A. W. Chucholowski, Roger S. Newton, Patrick Michael O'brien

Publikováno v: Journal of Medicinal Chemistry. 34:463-466

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9cd2384714439dd525427625a623fa9
https://doi.org/10.1021/jm00105a071

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Heterocyclic ureas: inhibitors of acyl-CoA:cholesterol O-acyltransferase as hypocholesterolemic agents

Autor: C. J. Blankley, A. W. Chucholowski, M. Neub, Andrew D. White, R. F. Bousley, K. L. Hamelehle, Mark Wallace Creswell, Brian R. Krause, M W Wilson, A. D. Essenburg, R. L. Stanfield, M. A. Dominick

Publikováno v: Journal of medicinal chemistry. 39(22)

A series of diaryl-substituted heterocyclic ureas was prepared, and their ability to inhibit acyl-CoA: cholesterol O-acyltransferase (ACAT) in vitro and to lower plasma total cholesterol in cholesterol-fed animal models in vivo was examined. N-(2,6-D

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f959b2e0ce6aa217eca366bcaa25b41
https://pubmed.ncbi.nlm.nih.gov/8893833

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Inhibitors of cholesterol biosynthesis. 3. Tetrahydro-4-hydroxy-6-[2-(1H-pyrrol-1-yl)ethyl]-2H-pyran-2-one inhibitors of HMG-CoA reductase. 2. Effects of introducing substituents at positions three and four of the pyrrole nucleus

Autor: Bruce D. Roth, C. J. Blankley, Catherine Sekerke, E. Ferguson, A. W. Chucholowski, Milton L. Hoefle, Roger S. Newton, Charlotte D. Stratton, Daniel F. Ortwine, D. R. Sliskovic

Publikováno v: Journal of medicinal chemistry. 34(1)

A series of trans-tetrahydro-4-hydroxy-6-[2-(2,3,4,5-substituted-1H-pyrrol-1-yl) ethyl]-2H-pyran-2-ones and their dihydroxy acids were prepared and tested for their ability to inhibit the enzyme HMG-CoA reductase in vitro. Inhibitory potency was foun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8cc1f80872bfb6e374a7d67e1aac12d
https://pubmed.ncbi.nlm.nih.gov/1992137

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