Neural Stem and Progenitor Cells Retain Their Potential for Proliferation and Differentiation into Functional Neurons Despite Lower Number in Aged Brain

Autor: Olle Lindvall, Henrik Ahlenius, Merab Kokaia, Zaal Kokaia, Violeta Visan

Publikováno v: The Journal of neuroscience : the official journal of the Society for Neuroscience; 29(14), pp 4408-4419 (2009)

Neurogenesis in the subventricular zone (SVZ), which gives rise to new neurons in the olfactory bulb, continues throughout life but declines with increasing age. Little is known about how aging affects the intrinsic properties of the neural stem and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::683ecb0f1f4ffb06b57975fc555f44cd
https://doi.org/10.1523/jneurosci.6003-08.2009

A Maurotoxin with Constrained Standard Disulfide Bridging

Autor: Mohamed El Ayeb, Hervé Rochat, Ignacio López-González, Sarrah Ben M’Barek, Ziad Fajloun, Jean-Marc Sabatier, Stephan Grissmer, Michel De Waard, Eric di Luccio, Nicolas Andreotti, Evelyne Beraud, A. Violeta Visan, Hervé Darbon, F. Sampieri, Susan I.V. Judge

Publikováno v: Journal of Biological Chemistry. 278:31095-31104

Maurotoxin (MTX) is a 34-residue toxin that has been isolated initially from the venom of the scorpion Scorpio maurus palmatus. It presents a large number of pharmacological targets, including small conductance Ca2+-activated and voltage-gated K+ cha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ddba1ae6527c41d3b87e3ca96cb99a12
https://doi.org/10.1074/jbc.m304271200

Calcium currents in rat entorhinal cortex layer II stellate and layer III pyramidal neurons in acute brain slice

Autor: Uwe Heinemann, Wolfgang Müller, Violeta Visan, Andriy Volynets

Publikováno v: Neuroscience Letters. 327:153-156

The entorhinal cortex (EC) is an essential relay station in neocortical – hippocampal information transfer and memory functions. Layer II stellate and layer III pyramidal neurons show specific damage in Alzheimer's disease and epilepsy, respectivel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6cd3620acdc75e5ecc73dc9c8368c19
https://doi.org/10.1016/s0304-3940(02)00339-7

Increasing the molecular contacts between maurotoxin and Kv1.2 channel augments ligand affinity

Autor: F. Sampieri, Benjamin Chagot, Mohamed El Ayeb, Nicolas Andreotti, Mohamed Marrakchi, Pascal Mansuelle, Stephan Grissmer, Jean-Marc Sabatier, Ziad Fajloun, Sarrah M'Barek, Michel De Waard, Violeta Visan, Hervé Darbon

Publikováno v: Proteins-Structure, Function and Bioinformatics
Proteins-Structure, Function and Bioinformatics, Wiley, 2005, 60 (3), pp.401-11. ⟨10.1002/prot.20509⟩
Proteins-Structure, Function and Bioinformatics, 2005, 60 (3), pp.401-11. ⟨10.1002/prot.20509⟩

International audience; Scorpion toxins interact with their target ion channels through multiple molecular contacts. Because a "gain of function" approach has never been described to evaluate the importance of the molecular contacts in defining toxin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af28e08bf1c2e1fcaa1f54383603b571
https://www.hal.inserm.fr/inserm-00381749

An apamin- and scyllatoxin-insensitive isoform of the human SK3 channel

Autor: Faiqa Imtiaz, Stephan Grissmer, Frank Lehmann-Horn, Jay J. Gargus, Deborah J. Morris-Rosendahl, Violeta Visan, Oliver H. Wittekindt, Hiroaki Tomita

Publikováno v: Molecular pharmacology. 65(3)

We have isolated an hSK3 isoform from a human embryonic cDNA library that we have named hSK3_ex4. This isoform contains a 15 amino acid insertion within the S5 to P-loop segment. Transcripts encoding hSK3_ex4 are coexpressed at lower levels with hSK3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::909b91907fa9a73cbee3c37f7e7b5d5a
https://pubmed.ncbi.nlm.nih.gov/14978258