Zobrazeno 1 - 10
of 561
pro vyhledávání: '"A. Van Ammel"'
Autor:
Mohamed Kreir, Dea Putri, Fetene Tekle, Francesca Pibiri, Constantin d’Ydewalle, Karel Van Ammel, Helena Geys, Ard Teisman, David J. Gallacher, Hua Rong Lu
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
We investigated drug-induced acute neuronal electrophysiological changes using Micro-Electrode arrays (MEA) to rat primary neuronal cell cultures. Data based on 6-key MEA parameters were analyzed for plate-to-plate vehicle variability, effects of pos
Externí odkaz:
https://doaj.org/article/6519f93f4908451c87b4f64f1cc25244
Autor:
C. Altrocchi, K. Van Ammel, M. Steemans, M. Kreir, F. Tekle, A. Teisman, D. J. Gallacher, H. R. Lu
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Introduction: Cardiotoxicity is one of the leading causes of compound attrition during drug development. Most in vitro screening platforms aim at detecting acute cardio-electrophysiological changes and drug-induced chronic functional alterations are
Externí odkaz:
https://doaj.org/article/d44739f6216b4c15814380bf7c3a9f7c
Autor:
Eva Persyn, Sigrid Wahlen, Laura Kiekens, Wouter Van Loocke, Hannah Siwe, Els Van Ammel, Zenzi De Vos, Filip Van Nieuwerburgh, Patrick Matthys, Tom Taghon, Bart Vandekerckhove, Pieter Van Vlierberghe, Georges Leclercq
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Natural killer (NK) cells are cytotoxic and cytokine-producing lymphocytes that play an important role in the first line of defense against malignant or virus-infected cells. A better understanding of the transcriptional regulation of human NK cell d
Externí odkaz:
https://doaj.org/article/74d32dc0a813471ba26a5d908fb198a5
Akademický článek
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The transcription factor RUNX2 drives the generation of human NK cells and promotes tissue residency
Autor:
Sigrid Wahlen, Filip Matthijssens, Wouter Van Loocke, Sylvie Taveirne, Laura Kiekens, Eva Persyn, Els Van Ammel, Zenzi De Vos, Stijn De Munter, Patrick Matthys, Filip Van Nieuwerburgh, Tom Taghon, Bart Vandekerckhove, Pieter Van Vlierberghe, Georges Leclercq
Publikováno v:
eLife, Vol 11 (2022)
Natural killer (NK) cells are innate lymphocytes that eliminate virus-infected and cancer cells by cytotoxicity and cytokine secretion. In addition to circulating NK cells, distinct tissue-resident NK subsets have been identified in various organs. A
Externí odkaz:
https://doaj.org/article/11397126237f4caebcb161863a688e20
Autor:
Hua-Rong Lu, Manabu Seo, Mohamed Kreir, Tetsuya Tanaka, Rie Yamoto, Cristina Altrocchi, Karel van Ammel, Fetene Tekle, Ly Pham, Xiang Yao, Ard Teisman, David J. Gallacher
Publikováno v:
Cells, Vol 12, Iss 6, p 958 (2023)
Drug-induced seizure liability is a significant safety issue and the basis for attrition in drug development. Occurrence in late development results in increased costs, human risk, and delayed market availability of novel therapeutics. Therefore, the
Externí odkaz:
https://doaj.org/article/30146c9b38b545e3a4445329880d9e44
Autor:
Hua Rong Lu, Mohamed Kreir, Van Ammel Karel, Fetene Tekle, Danny Geyskens, Ard Teisman, David J. Gallacher
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Introduction: Early identification of cardiac risk is essential for reducing late-stage attrition in drug development. We adapted the previously published cardiac hazard risk-scoring system using a calcium transient assay in human stem cell-derived C
Externí odkaz:
https://doaj.org/article/55eee77037354205947cc96ae57ef5ed
Akademický článek
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Autor:
Laura Kiekens, Wouter Van Loocke, Sylvie Taveirne, Sigrid Wahlen, Eva Persyn, Els Van Ammel, Zenzi De Vos, Patrick Matthys, Filip Van Nieuwerburgh, Tom Taghon, Pieter Van Vlierberghe, Bart Vandekerckhove, Georges Leclercq
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
T-bet and Eomes are transcription factors that are known to be important in maturation and function of murine natural killer (NK) cells. Reduced T-BET and EOMES expression results in dysfunctional NK cells and failure to control tumor growth. In cont
Externí odkaz:
https://doaj.org/article/9f67899823494ff2b3876e1459bfeadd
Autor:
Ivan Kopljar, Hua Rong Lu, Karel Van Ammel, Martin Otava, Fetene Tekle, Ard Teisman, David J. Gallacher
Publikováno v:
Stem Cell Reports, Vol 11, Iss 6, Pp 1365-1377 (2018)
Summary: Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have emerged as a promising cardiac safety platform, demonstrated by numerous validation studies using drugs with known cardiac adverse effects in humans. However, the ch
Externí odkaz:
https://doaj.org/article/c94301ff0e65459abf10dca1af2b44a1