Zobrazeno 1 - 10
of 83
pro vyhledávání: '"A. V. Pindyurin"'
Publikováno v:
Вавиловский журнал генетики и селекции, Vol 27, Iss 7, Pp 906-915 (2023)
CHO cells are most commonly used for the synthesis of recombinant proteins in biopharmaceutical production. When stable producer cell lines are obtained, the locus of transgene integration into the genome has a great influence on the level of its exp
Externí odkaz:
https://doaj.org/article/94b243e0ceef45838f0bbe9a68c5c051
Autor:
E. N. Andreyeva, A. A. Ogienko, A. A. Yushkova, J. V. Popova, G. A. Pavlova, E. N. Kozhevnikova, A. V. Ivankin, M. Gatti, A. V. Pindyurin
Publikováno v:
Вавиловский журнал генетики и селекции, Vol 23, Iss 2, Pp 190-198 (2019)
The nucleolus is a dynamic non-membrane-bound nuclear organelle, which plays key roles not only in ribosome biogenesis but also in many other cellular processes. Consistent with its multiple functions, the nucleolus has been implicated in many human
Externí odkaz:
https://doaj.org/article/6a68bd9357b7490188c8deb6fc520616
Publikováno v:
Вавиловский журнал генетики и селекции, Vol 23, Iss 2, Pp 203-211 (2019)
The discovery of the position effect variegation phenomenon and the subsequent comprehensive analysis of its molecular mechanisms led to understanding that the local chromatin composition has a dramatic effect on gene activity. To study this effect i
Externí odkaz:
https://doaj.org/article/c3187384909d4362906da6d3fdff93eb
Autor:
E. S. Omelina, A. V. Pindyurin
Publikováno v:
Вавиловский журнал генетики и селекции, Vol 23, Iss 2, Pp 219-225 (2019)
Despite the rapid development of approaches aimed to precisely control transcription of exogenous genes in time and space, design of systems providing similar tight regulation of endogenous gene expression is much more challenging. However, finding w
Externí odkaz:
https://doaj.org/article/f358f5ce0fdc4eb499bd5a1b580a7757
Autor:
L. P. Zakharenko, D. V. Petrovskii, I. G. Dranov, S. A. Fedorova, N. S. Yudin, A. V. Pindyurin, Y. M. Moshkin
Publikováno v:
Вавиловский журнал генетики и селекции, Vol 21, Iss 7, Pp 816-824 (2017)
Long-lived systems are expected to be stable, i. e. resistant to either external influences, or internal failures. Robustness of biological systems can be defined as a reciprocal value to their phenotypic plasticity expressed through a coefficient of
Externí odkaz:
https://doaj.org/article/12c0718049564042bdb109f2631cf71f
Autor:
Alexander A. Dolskiy, Andrey A. Yarushkin, Irina V. Grishchenko, Natalya A. Lemskaya, Alexey V. Pindyurin, Lidiya V. Boldyreva, Vladimir O. Pustylnyak, Dmitry V. Yudkin
Publikováno v:
Non-coding RNA Research, Vol 6, Iss 1, Pp 1-7 (2021)
FRAXopathies are caused by the expansion of the CGG repeat in the 5′UTR of the FMR1 gene, which encodes the protein responsible for the synthesis of FMRP. This mutation leads to dramatic changes in FMRP expression at both the mRNA and protein level
Externí odkaz:
https://doaj.org/article/b7bf439764c74c6aac61b6cf5c21185f
Autor:
Anna A. Ogienko, Evgeniya N. Andreyeva, Evgeniya S. Omelina, Anastasiya L. Oshchepkova, Alexey V. Pindyurin
Publikováno v:
BMC Genetics, Vol 21, Iss S1, Pp 1-11 (2020)
Abstract Background The Drosophila central nervous system (CNS) is a convenient model system for the study of the molecular mechanisms of conserved neurobiological processes. The manipulation of gene activity in specific cell types and subtypes of th
Externí odkaz:
https://doaj.org/article/37ffbf2f062249189bde973034b2bed2
Publikováno v:
BMC Genomics, Vol 20, Iss S7, Pp 1-10 (2019)
Abstract Background Massively parallel reporter assays (MPRAs) enable high-throughput functional evaluation of various DNA regulatory elements and their mutant variants. The assays are based on construction of highly diverse plasmid libraries contain
Externí odkaz:
https://doaj.org/article/ae2faaa1610d41db9ffeb8a9878a9bf9
Autor:
Santiago Gisler, Joana P. Gonçalves, Waseem Akhtar, Johann de Jong, Alexey V. Pindyurin, Lodewyk F. A. Wessels, Maarten van Lohuizen
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Designing effective genome engineering strategies requires an understanding of the impact that genomic locus has on CRISPR-Cas9 activity. Here the authors use TRIP integrations to profile editing outcomes genome-wide and observe that gRNA sequence in
Externí odkaz:
https://doaj.org/article/8cafb83aa5a34b2b9543a0254a16b6e2
Autor:
Gera A. Pavlova, Alyona V. Razuvaeva, Julia V. Popova, Evgeniya N. Andreyeva, Lyubov A. Yarinich, Mikhail O. Lebedev, Claudia Pellacani, Silvia Bonaccorsi, Maria Patrizia Somma, Maurizio Gatti, Alexey V. Pindyurin
Publikováno v:
BMC Molecular and Cell Biology, Vol 20, Iss S1, Pp 1-13 (2019)
Abstract Background The calmodulin-regulated spectrin-associated proteins (CAMSAPs) belong to a conserved protein family, which includes members that bind the polymerizing mcrotubule (MT) minus ends and remain associated with the MT lattice formed by
Externí odkaz:
https://doaj.org/article/82654c3f397a41b3a69ffb2e63979cb8