Zobrazeno 1 - 5
of 5
pro vyhledávání: '"A. V. Mukovnya"'
Autor:
V. L. Tunitskaya, Sergey N. Kochetkov, V. V. Komissarov, Vladimir A. Mitkevich, A. V. Mukovnya, A. M. Kritsyn
Publikováno v:
Molecular Biology. 44:931-938
Nonstructural protein 3 (NS3) of hepatitis C virus plays a key role in the functioning of the virus. NS3 displays three enzymatic activities, namely, protease activity associated with the N-terminal domain, coupled nucleoside triphosphotase (NTPase),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f44671705aef47cbe2732101b31bdcfa
https://doi.org/10.1134/s0026893310060105
https://doi.org/10.1134/s0026893310060105
Autor:
G. S. Ludva, A. V. Mukovnya, M. A. Ivanov, Sergey N. Kochetkov, V. L. Tunitskaya, L. A. Alexandrova
Publikováno v:
Russian Journal of Bioorganic Chemistry. 36:488-496
4′-Fluoro-2′,3′-O-isopropylidenecytidine was synthesized by the treatment of 5′-O-acetyl-4′-fluoro-2′,3′-O-isopropylideneuridine with triazole and 4-chlorophenyl dichlorophosphate followed by ammonolysis. The interaction of 4′-fluoro-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::393d4ee5fe6bb14bf8c6c4ef877ae3c5
https://doi.org/10.1134/s1068162010040072
https://doi.org/10.1134/s1068162010040072
Autor:
N. F. Zakirova, N. A. Golubeva, Sergey N. Kochetkov, A. V. Mukovnya, Marina K. Kukhanova, A. L. Khandazhinskaya, V. L. Tunitskaya, Alexander V. Ivanov
Publikováno v:
Biochemistry (Moscow). 73:660-668
A method has been developed for obtaining a full-length protein NS3 of hepatitis C virus with the yield of 6.5 mg/liter of cell culture, and conditions for measuring its NTPase and helicase activities have been optimized. The helicase reaction can pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::842160375bf4bc4ffaaa15f8c9710293
https://doi.org/10.1134/s0006297908060059
https://doi.org/10.1134/s0006297908060059
Publikováno v:
Russian Journal of Physical Chemistry A. 81:701-705
The ozonization of several model lignin compounds (guaiacol, 2,6-dimethoxyphenol, phenol, and vanillin) was studied in acid media in the presence of iron(III) ions. It was found that Fe3+ did not influence the initial rate of the reactions between mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f3a25b28fa7ad6502702b3c575f2e332
https://doi.org/10.1134/s003602440705007x
https://doi.org/10.1134/s003602440705007x
Inhibition of the helicase activity of the HCV NS3 protein by symmetrical dimeric bis-benzimidazoles
Autor:
Alexander V. Ivanov, Alexei L. Zhuze, Sergey N. Kochetkov, Alexander V. Gromyko, Anna V. Mukovnya, Vera L. Tunitskaya, Alexander A. Ivanov, Strel'tsov Sa
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(18)
Dimeric bis-benzimidazoles ( DBn ) are the compounds specifically binding to A–T enriched sequences in the DNA minor groove. Due to this property they can inhibit DNA-dependent enzymes. We show that inhibition of the helicase activity of HCV NS3 pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2f09d10baf9db1bbf40d2802f7a8925
https://pubmed.ncbi.nlm.nih.gov/21821416
https://pubmed.ncbi.nlm.nih.gov/21821416