Zobrazeno 1 - 10
of 97
pro vyhledávání: '"A. V. Graf"'
Autor:
Vasily A. Aleshin, Anastasia V. Graf, Artem V. Artiukhov, Alexander L. Ksenofontov, Lev G. Zavileyskiy, Maria V. Maslova, Victoria I. Bunik
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 15, p 12405 (2023)
Epilepsy is characterized by recurrent seizures due to a perturbed balance between glutamate and GABA neurotransmission. Our goal is to reveal the molecular mechanisms of the changes upon repeated challenges of this balance, suggesting knowledge-base
Externí odkaz:
https://doaj.org/article/a1a9d142a6064df68a573a7a67bffaf0
Autor:
Alexandra I. Boyko, Irina S. Karlina, Lev G. Zavileyskiy, Vasily A. Aleshin, Artem V. Artiukhov, Thilo Kaehne, Alexander L. Ksenofontov, Sergey I. Ryabov, Anastasia V. Graf, Angela Tramonti, Victoria I. Bunik
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
BackgroundThe DHTKD1-encoded 2-oxoadipate dehydrogenase (OADH) oxidizes 2-oxoadipate—a common intermediate of the lysine and tryptophan catabolism. The mostly low and cell-specific flux through these pathways, and similar activities of OADH and ubi
Externí odkaz:
https://doaj.org/article/c348e03e0bc340388c2b955d9ea9932f
Autor:
Victoria I. Bunik, Artem V. Artiukhov, Alexey V. Kazantsev, Vasily A. Aleshin, Alexandra I. Boyko, Alexander L. Ksenofontov, Nikolay V. Lukashev, Anastasia V. Graf
Publikováno v:
Frontiers in Chemistry, Vol 10 (2022)
In vitro and in cell cultures, succinyl phosphonate (SP) and adipoyl phosphonate (AP) selectively target dehydrogenases of 2-oxoglutarate (OGDH, encoded by OGDH/OGDHL) and 2-oxoadipate (OADH, encoded by DHTKD1), respectively. To assess the selectivit
Externí odkaz:
https://doaj.org/article/ae420945964148f7aeda0e9e80f8ae1c
Autor:
Artem V. Artiukhov, Vasily A. Aleshin, Irina S. Karlina, Alexey V. Kazantsev, Daria A. Sibiryakina, Alexander L. Ksenofontov, Nikolay V. Lukashev, Anastasia V. Graf, Victoria I. Bunik
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 21, p 13186 (2022)
Mitochondrial pyruvate dehydrogenase complex (PDHC) is essential for brain glucose and neurotransmitter metabolism, which is dysregulated in many pathologies. Using specific inhibitors of PDHC in vivo, we determine biochemical and physiological respo
Externí odkaz:
https://doaj.org/article/8fc7119b85cd4226a226b086d51a144c
Autor:
Lev G. Zavileyskiy, Vasily A. Aleshin, Thilo Kaehne, Irina S. Karlina, Artem V. Artiukhov, Maria V. Maslova, Anastasia V. Graf, Victoria I. Bunik
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 20, p 12302 (2022)
Abnormal energy expenditure during seizures and metabolic regulation through post-translational protein acylation suggest acylation as a therapeutic target in epilepsy. Our goal is to characterize an interplay between the brain acylation system compo
Externí odkaz:
https://doaj.org/article/8175e1acab69423f80efb3afeafd6d87
Autor:
Vasily A. Aleshin, Daria A. Sibiryakina, Alexey V. Kazantsev, Anastasia V. Graf, Victoria I. Bunik
Publikováno v:
Biochemistry (Moscow). 88:105-118
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de5c56c067e3f99f3b42873f32d97866
https://doi.org/10.1134/s0006297923010091
https://doi.org/10.1134/s0006297923010091
Autor:
Anastasia V. Graf, Maria V. Maslova, Artem V. Artiukhov, Alexander L. Ksenofontov, Vasily A. Aleshin, Victoria I. Bunik
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 5, p 2579 (2022)
Hypoxia is damaging to the fetus, but the developmental impact may vary, with underlying molecular mechanisms unclear. We demonstrate the dependence of physiological and biochemical effects of acute prenatal hypoxia (APH) on sex and gestational age.
Externí odkaz:
https://doaj.org/article/bc9c5045fc1b4220b6c5fbfdb9df58c8
Autor:
Artem V. Artiukhov, Anastasia V. Graf, Alexey V. Kazantsev, Alexandra I. Boyko, Vasily A. Aleshin, Alexander L. Ksenofontov, Victoria I. Bunik
Publikováno v:
Pharmaceuticals, Vol 15, Iss 2, p 182 (2022)
Specific inhibitors of mitochondrial 2-oxoglutarate dehydrogenase (OGDH) are administered to animals to model the downregulation of the enzyme as observed in neurodegenerative diseases. Comparison of the effects of succinyl phosphonate (SP, 0.02 mmol
Externí odkaz:
https://doaj.org/article/867d7deacd654458964e5cadcd3ee852
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 15, p 8006 (2021)
Coupling glycolysis and mitochondrial tricarboxylic acid cycle, pyruvate dehydrogenase (PDH) complex (PDHC) is highly responsive to cellular demands through multiple mechanisms, including PDH phosphorylation. PDHC also produces acetyl-CoA for protein
Externí odkaz:
https://doaj.org/article/bd919f9d4d4341ccb64c3138ed154b8d
Autor:
Vasily A. Aleshin, Anastasia V. Graf, Artem V. Artiukhov, Alexandra I. Boyko, Alexander L. Ksenofontov, Maria V. Maslova, Isabel Nogués, Martino L. di Salvo, Victoria I. Bunik
Publikováno v:
Pharmaceuticals, Vol 14, Iss 8, p 737 (2021)
The disturbed metabolism of vitamins B1 or B6, which are essential for neurotransmitters homeostasis, may cause seizures. Our study aims at revealing therapeutic potential of vitamins B1 and B6 by estimating the short- and long-term effects of their
Externí odkaz:
https://doaj.org/article/f9a0968204bc444d8af13175f4f576c4