Zobrazeno 1 - 10 of 91 pro vyhledávání: '"A. V. Graf"'
1
Akademický článek
Delayed Impact of 2-Oxoadipate Dehydrogenase Inhibition on the Rat Brain Metabolism Is Linked to Protein Glutarylation
Autor: Alexandra I. Boyko, Irina S. Karlina, Lev G. Zavileyskiy, Vasily A. Aleshin, Artem V. Artiukhov, Thilo Kaehne, Alexander L. Ksenofontov, Sergey I. Ryabov, Anastasia V. Graf, Angela Tramonti, Victoria I. Bunik
Publikováno v: Frontiers in Medicine, Vol 9 (2022)
BackgroundThe DHTKD1-encoded 2-oxoadipate dehydrogenase (OADH) oxidizes 2-oxoadipate—a common intermediate of the lysine and tryptophan catabolism. The mostly low and cell-specific flux through these pathways, and similar activities of OADH and ubi
Externí odkaz: https://doaj.org/article/c348e03e0bc340388c2b955d9ea9932f
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3
Akademický článek
Increasing Inhibition of the Rat Brain 2-Oxoglutarate Dehydrogenase Decreases Glutathione Redox State, Elevating Anxiety and Perturbing Stress Adaptation
Autor: Artem V. Artiukhov, Anastasia V. Graf, Alexey V. Kazantsev, Alexandra I. Boyko, Vasily A. Aleshin, Alexander L. Ksenofontov, Victoria I. Bunik
Publikováno v: Pharmaceuticals, Vol 15, Iss 2, p 182 (2022)
Specific inhibitors of mitochondrial 2-oxoglutarate dehydrogenase (OGDH) are administered to animals to model the downregulation of the enzyme as observed in neurodegenerative diseases. Comparison of the effects of succinyl phosphonate (SP, 0.02 mmol
Externí odkaz: https://doaj.org/article/867d7deacd654458964e5cadcd3ee852
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4
Akademický článek
Physiological and Biochemical Markers of the Sex-Specific Sensitivity to Epileptogenic Factors, Delayed Consequences of Seizures and Their Response to Vitamins B1 and B6 in a Rat Model
Autor: Vasily A. Aleshin, Anastasia V. Graf, Artem V. Artiukhov, Alexandra I. Boyko, Alexander L. Ksenofontov, Maria V. Maslova, Isabel Nogués, Martino L. di Salvo, Victoria I. Bunik
Publikováno v: Pharmaceuticals, Vol 14, Iss 8, p 737 (2021)
The disturbed metabolism of vitamins B1 or B6, which are essential for neurotransmitters homeostasis, may cause seizures. Our study aims at revealing therapeutic potential of vitamins B1 and B6 by estimating the short- and long-term effects of their
Externí odkaz: https://doaj.org/article/f9a0968204bc444d8af13175f4f576c4
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6
Inhibition of pyruvate dehydrogenase affects the brain protein acylation stronger than PDHA phosphorylation at Ser293
Autor: Vasily A. Aleshin, Daria A. Sibiryakina, Alexey V. Kazantsev, Anastasia V. Graf, Victoria I. Bunik
Adaptation of an organism to metabolic challenges requires mechanisms coupling metabolism to gene expression. Acylations of metabolic and histone proteins acquire significant attention in this regard. We hypothesize that adaptive response to inhibiti
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f769b0940bffcf272e7f59dc63f96c23
https://doi.org/10.1101/2022.11.10.515938
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8
Phosphonate Inhibitors of Pyruvate Dehydrogenase Perturb Homeostasis of Amino Acids and Protein Succinylation in the Brain
Autor: Artem V. Artiukhov, Vasily A. Aleshin, Irina S. Karlina, Alexey V. Kazantsev, Daria A. Sibiryakina, Alexander L. Ksenofontov, Nikolay V. Lukashev, Anastasia V. Graf, Victoria I. Bunik
Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 21; Pages: 13186
Mitochondrial pyruvate dehydrogenase complex (PDHC) is essential for brain glucose and neurotransmitter metabolism, which is dysregulated in many pathologies. Using specific inhibitors of PDHC in vivo, we determine biochemical and physiological respo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea7e28014dde44974f0af6fb5cec0386
https://pubmed.ncbi.nlm.nih.gov/36361974
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9
Akademický článek
Construction of a prototype of the basic module of a scalable robotic system for simulation of composite surfaces for dynamic tests
Autor: A. V. Grafkin, D. I. Ponamarenko
Publikováno v: Вестник Самарского университета: Аэрокосмическая техника, технологии и машиностроение, Vol 23, Iss 3, Pp 167-177 (2024)
The authors of the article developed a mathematical model of Stewart platform management. The angles of rotation of the servo shafts were obtained when setting various laws of motion of the mobile platform, in matrix mode. The hardware part of the pr
Externí odkaz: https://doaj.org/article/8d5e0dd4bacc41b7973ff0fc7255dd44
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10
Administration of Phosphonate Inhibitors of Dehydrogenases of 2-Oxoglutarate and 2-Oxoadipate to Rats Elicits Target-Specific Metabolic and Physiological Responses
Autor: Victoria I, Bunik, Artem V, Artiukhov, Alexey V, Kazantsev, Vasily A, Aleshin, Alexandra I, Boyko, Alexander L, Ksenofontov, Nikolay V, Lukashev, Anastasia V, Graf
Publikováno v: Frontiers in Chemistry. 10
In vitro and in cell cultures, succinyl phosphonate (SP) and adipoyl phosphonate (AP) selectively target dehydrogenases of 2-oxoglutarate (OGDH, encoded by OGDH/OGDHL) and 2-oxoadipate (OADH, encoded by DHTKD1), respectively. To assess the selectivit
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dcb1ee6a6ad9defc71d9593980a3b77
https://doi.org/10.3389/fchem.2022.892284
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