Zobrazeno 1 - 10
of 27
pro vyhledávání: '"A. V. Gabrel'yan"'
Autor:
Kseniya N. Sedenkova, Denis V. Zverev, Anna A. Nazarova, Mstislav I. Lavrov, Eugene V. Radchenko, Yuri K. Grishin, Alexey V. Gabrel’yan, Vladimir L. Zamoyski, Vladimir V. Grigoriev, Elena B. Averina, Vladimir A. Palyulin
Publikováno v:
Molecules, Vol 27, Iss 23, p 8252 (2022)
Positive allosteric modulators (PAMs) of AMPA receptors represent attractive candidates for the development of drugs for the treatment of cognitive and neurodegenerative disorders. Dimeric molecules have been reported to have an especially potent mod
Externí odkaz:
https://doaj.org/article/0407b9018059428e84eb2f481bc3d013
Autor:
Dmitry S. Karlov, Nadezhda S. Temnyakova, Dmitry A. Vasilenko, Oleg I. Barygin, Mikhail Y. Dron, Arseniy S. Zhigulin, Elena B. Averina, Yuri K. Grishin, Vladimir V. Grigoriev, Alexey V. Gabrel'yan, Viktor A. Aniol, Natalia V. Gulyaeva, Sergey V. Osipenko, Yury I. Kostyukevich, Vladimir A. Palyulin, Petr A. Popov, Maxim V. Fedorov
Publikováno v:
RSC Med Chem
NMDA (N-methyl-d-aspartate) receptor antagonists are promising tools for the treatment of a wide variety of central nervous system impairments including major depressive disorder. We present here the activity optimization process of a biphenyl-based
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d3989af29a2bde731d47b62baa8a167
https://doi.org/10.1039/d2md00001f
https://doi.org/10.1039/d2md00001f
Publikováno v:
Russian Chemical Bulletin. 70:2180-2184
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fbe1a0397eb7c440b164128f73834e73
https://doi.org/10.1007/s11172-021-3329-6
https://doi.org/10.1007/s11172-021-3329-6
Autor:
Vladimir V. Grigoriev, T. V. Goreva, V. B. Sokolov, A. Yu. Aksinenko, A. V. Gabrel’yan, T. A. Epishina
Publikováno v:
Russian Journal of General Chemistry. 90:32-38
Copper-catalyzed alkyne-azide 1,3-dipolar cycloaddition of methyl esters of N-azidoacetyl-2-aminothiophene-3-carboxylic acids to N-propargyl-containing pharmacophores, resulting in the corresponding conjugates combined by 1,2,3-triazole-containing al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f8a09d51e44a93479d72b68d3c6b92b
https://doi.org/10.1134/s1070363220010053
https://doi.org/10.1134/s1070363220010053
Publikováno v:
Russian Chemical Bulletin. 68:1629-1632
Methyl N-(carbazolyl)acetyl-2-aminotetrahydrothiophene-3-carboxylates were synthesized by alkylation of carbazoles with the corresponding chloroacetylamides of 2-aminotiophenes. The radioligand binding method showed the presence of the modulating eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6c1ffe40f08fedde286301b47aa6732
https://doi.org/10.1007/s11172-019-2602-4
https://doi.org/10.1007/s11172-019-2602-4
Autor:
Rudy J. Richardson, L. G. Dubova, Tatiana A. Epishina, A. V. Gabrel’yan, Alexey Yu. Aksinenko, Vladimir V. Grigoriev, Nadezhda V. Kovaleva, Galina F. Makhaeva, Vladimir P. Fisenko, Elena V. Rudakova, Elena F. Shevtsova, Elena A. Pushkareva, N. P. Boltneva, Sergey O. Bachurin, V. L. Zamoyski, Tatiana V. Goreva, Sofya V. Lushchekina, P. N. Shevtsov, Elena V. Bovina
Publikováno v:
Molecules
Volume 26
Issue 18
Molecules, Vol 26, Iss 5527, p 5527 (2021)
Volume 26
Issue 18
Molecules, Vol 26, Iss 5527, p 5527 (2021)
A new series of conjugates of aminoadamantane and γ-carboline, which are basic scaffolds of the known neuroactive agents, memantine and dimebon (Latrepirdine) was synthesized and characterized. Conjugates act simultaneously on several biological str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3ca8936ff5ecf3273219d1c01fb5275
https://doi.org/10.3390/molecules26185527
https://doi.org/10.3390/molecules26185527
Autor:
A. V. Gabrel’yan, A. Yu. Aksinenko, V. B. Sokolov, T. V. Goreva, T. A. Epishina, Vladimir V. Grigoriev
Publikováno v:
Russian Chemical Bulletin. 66:552-557
An approach to modify biologically active carbazoles and tetrahydrocarbazoles with 2-trifluoromethyl and 2-methoxycarbonyl(imidazo[1,2-a]pyridin-3-yl)propionylamidic fragments by interaction of N-methyl-N-[2-trifluoromethylimidazo[1,2-a]pyridin-3-yl]
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eff03cc60f1d821fd49911f5a63b4e9c
https://doi.org/10.1007/s11172-017-1770-3
https://doi.org/10.1007/s11172-017-1770-3
Autor:
V. B. Sokolov, Sergey O. Bachurin, V. V. Grigor’ev, O. A. Dranii, T. A. Epishina, A. Yu. Aksinenko, T. V. Goreva, A. V. Gabrel’yan
Publikováno v:
Russian Journal of General Chemistry. 85:1452-1455
Modification of biologically active cycloalkaneindoles by incorporation of a 2-trifluoromethylimidazo[1,2-a]pyridin-6-yl fragment has been proposed and performed via the interaction with 3-fluoro-2-trifluoromethylimidazo[1,2-a]pyridines in the presen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2cfc9a8c69956780f511c66379f5d7b2
https://doi.org/10.1134/s1070363215060158
https://doi.org/10.1134/s1070363215060158
Autor:
Sergey O. Bachurin, Margarita E. Neganova, Elena F. Shevtsova, Sofya V. Lushchekina, Galina F. Makhaeva, N. P. Boltneva, Elena V. Bovina, P. N. Shevtsov, V. B. Sokolov, O. M. Redkozubova, George E. Barreto, Vladimir V. Grigoriev, Gjumrakch Aliev, Nadezhda V. Kovaleva, Valentina Echeverria, A. V. Gabrel’yan, Vladimir P. Fisenko, Alexey Yu. Aksinenko
Publikováno v:
Scientific Reports
A new group of compounds, promising for the design of original multitarget therapeutic agents for treating neurodegenerative diseases, based on conjugates of aminoadamantane and carbazole derivatives was synthesized and investigated. Compounds of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e0092abf068b5729dab884e4bd1be01
https://doi.org/10.1038/srep45627
https://doi.org/10.1038/srep45627
Autor:
P.N. Shkumat, I.Yu. Zavalii, O. Yu. Khizhun, B. V. Gabrel’yan, A. A. Lavrentyev, E.I. Kopylova, A.K. Sinelnichenko
Publikováno v:
Reports of the National Academy of Sciences of Ukraine. :76-81
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1414609d18d96718283cccd0c1cc564c
https://doi.org/10.15407/dopovidi2014.04.076
https://doi.org/10.15407/dopovidi2014.04.076