Expression of the NUP153 and YWHAB genes from their canonical promoters and alternative promoters of the LINE-1 retrotransposon in the placenta of the first trimester of pregnancy

Autor: V. V. Demeneva, E. N. Tolmacheva, T. V. Nikitina, E. A. Sazhenova, S. Yu. Yuriev, A. Sh. Makhmutkhodzhaev, A. S. Zuev, S. A. Filatova, A. E. Dmitriev, Ya. A. Darkova, L. P. Nazarenko, I. N. Lebedev, S. A. Vasilyev

Publikováno v: Вавиловский журнал генетики и селекции, Vol 27, Iss 1, Pp 63-71 (2023)

The placenta has a unique hypomethylated genome. Due to this feature of the placenta, there is a potential possibility of using regulatory elements derived from retroviruses and retrotransposons, which are suppressed by DNA methylation in the adult b

Externí odkaz: https://doaj.org/article/5a1a5fd8039a49aa8d6121a82b380e40

Combined whole exome sequencing and chromosomal microarray analysis improve clinical interpretation of genomic variants in patients with intellectual disability

Autor: A. A. Kashevarova, E. O. Belyaeva, E. A. Fonova, M. E. Lopatkina, O. Y. Vasilyeva, D. A. Fedotov, A. A. Zarubin, A. A. Sivtsev, V. V. Demeneva, O. A. Salyukova, V. V. Petrova, S. V. Fadiushina, L. I. Minaycheva, G. N. Seitova, L. P. Nazarenko, I. N. Lebedev

Publikováno v: European Psychiatry, Vol 66, Pp S887-S887 (2023)

Introduction aCGH determines pathogenic copy number variations (CNVs) in about 10% of patients with intellectual disability (ID). In another 20% of patients, probably pathogenic CNVs or variants with uncertain clinical significance are detected. It m

Externí odkaz: https://doaj.org/article/40662c68514145aab44af67c6d70bd1d

Method of targeted bisulfite massive parallel sequencing of the human LINE-1 retrotransposon promoter

Autor: Stanislav A. Vasilyev, Anton V. Markov, Oksana Yu. Vasilyeva, Ekaterina N. Tolmacheva, Lada A. Zatula, Diana V. Sharysh, Daria I. Zhigalina, Victoria V. Demeneva, Igor N. Lebedev

Publikováno v: MethodsX, Vol 8, Iss , Pp 101445- (2021)

The methylation index of the LINE-1 promoter is one of the most commonly used markers for assessing the global level of genome methylation in various human cells and tissues. We developed an NGS-based protocol for DNA methylation analysis of the LINE

Externí odkaz: https://doaj.org/article/13b48e39f04e4f12b166c0d37b2af4f9

Identification of differentially methylated genes in first-trimester placentas with trisomy 16

Autor: Ekaterina N. Tolmacheva, Stanislav A. Vasilyev, Tatiana V. Nikitina, Ekaterina S. Lytkina, Elena A. Sazhenova, Daria I. Zhigalina, Oksana Yu. Vasilyeva, Anton V. Markov, Victoria V. Demeneva, Liubov A. Tashireva, Anna A. Kashevarova, Igor N. Lebedev

Publikováno v: Scientific Reports
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Scientific Reports [Еlectronic resource]. 2022. Vol. 12. P. 1166 (1-12)

The presence of an extra chromosome in the embryo karyotype often dramatically affects the fate of pregnancy. Trisomy 16 is the most common aneuploidy in first-trimester miscarriages. The present study identified changes in DNA methylation in chorion

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14ada9fd795a3cd25bab29c437c2a38b
https://pubmed.ncbi.nlm.nih.gov/35064135

Regularities of high-temperature oxidation of current collectors of solid oxide fuel cells due to diffusion processes in subsurface regions

Autor: Sergey Bredikhin, Danila Matveev, Vladislav V. Kharton, N. V. Demeneva

Publikováno v: Russian Journal of Electrochemistry. 52:678-684

A complex study of regularities of oxidative reactions is carried out in subsurface layers of current collectors of solid oxide fuel cells manufactured of Crofer 22APU or Crofer 22H stainless steel. The methods of scanning electron microscopy, energy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fa49d52f09b9a2b3c86df0bac3c47e5e
https://doi.org/10.1134/s1023193516070065