Zobrazeno 1 - 10
of 67
pro vyhledávání: '"A. Turpoff"'
Autor:
Naryshkin, Nikolai A., Weetall, Marla, Dakka, Amal, Narasimhan, Jana, Zhao, Xin, Feng, Zhihua, Ling, Karen K. Y., Karp, Gary M., Qi, Hongyan, Woll, Matthew G., Chen, Guangming, Zhang, Nanjing, Gabbeta, Vijayalakshmi, Vazirani, Priya, Bhattacharyya, Anuradha, Furia, Bansri, Risher, Nicole, Sheedy, Josephine, Kong, Ronald, Ma, Jiyuan, Turpoff, Anthony, Lee, Chang-Sun, Zhang, Xiaoyan, Moon, Young-Choon, Trifillis, Panayiota, Welch, Ellen M., Colacino, Joseph M., Babiak, John, Almstead, Neil G., Peltz, Stuart W., Eng, Loren A., Chen, Karen S., Mull, Jesse L., Lynes, Maureen S., Rubin, Lee L., Fontoura, Paulo, Santarelli, Luca, Haehnke, Daniel, McCarthy, Kathleen D., Schmucki, Roland, Ebeling, Martin, Sivaramakrishnan, Manaswini, Ko, Chien-Ping, Paushkin, Sergey V., Ratni, Hasane, Gerlach, Irene, Ghosh, Anirvan, Metzger, Friedrich
Publikováno v:
Science, 2014 Aug 01. 345(6197), 688-693.
Externí odkaz:
http://www.jstor.org/stable/24745276
Autor:
Tianle Yang, Hasane Ratni, Emmanuel Pinard, Nanjing Zhang, Hongyan Qi, Nikolai Naryshkin, Priya Vazirani, Stephan Kirchner, Xiaoyan Zhang, Karen S. Chen, Amal Dakka, Lutz Mueller, Friedrich Metzger, Woll Matthew G, Sergey Paushkin, Xin Zhao, Marla Weetall, Gary Mitchell Karp, Kathleen D. McCarthy, Agnès Poirier, Wolfgang Muster, Pascale David-Pierson, Luke Green, Irene Gerlach, Anthony Turpoff, Dietrich Tuerck
Publikováno v:
Journal of Medicinal Chemistry. 59:6086-6100
Spinal muscular atrophy (SMA) is the leading genetic cause of infant and toddler mortality, and there is currently no approved therapy available. SMA is caused by mutation or deletion of the survival motor neuron 1 (SMN1) gene. These mutations or del
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::893761e5e7ae4b3161242bfe14378561
https://doi.org/10.1021/acs.jmedchem.6b00459
https://doi.org/10.1021/acs.jmedchem.6b00459
Autor:
Song Huang, Jason D. Graci, Paul Ingravallo, Anthony Turpoff, Neil Gregory Almstead, John Pichardo, Nanjing Zhang, Joseph M. Colacino, F. George Njoroge, Yalei Liu, Zhengxian Gu, Marla Weetall, Frederick C. Lahser, Stephen P. Jung, Gary Mitchell Karp, Amin A. Nomeir, Xiaoyan Zhang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:594-601
A novel series of 2-(4-sulfonamidophenyl)-indole 3-carboxamides was identified and optimized for activity against the HCV genotype 1b replicon resulting in compounds with potent and selective activity. Further evaluation of this series demonstrated p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99f2dde02f0aa0ffaf8e4d127e01fcf0
https://doi.org/10.1016/j.bmcl.2015.11.065
https://doi.org/10.1016/j.bmcl.2015.11.065
Autor:
Chien-Ping Ko, Luca Santarelli, Hasane Ratni, Roland Schmucki, Maureen S. Lynes, Josephine Sheedy, Sergey Paushkin, Chang-Sun Lee, Irene Gerlach, Jesse L. Mull, Nanjing Zhang, Zhihua Feng, Anthony Turpoff, Anuradha Bhattacharyya, Paulo Fontoura, Priya Vazirani, Panayiota Trifillis, Gary Mitchell Karp, Joseph M. Colacino, Martin Ebeling, Kathleen D. McCarthy, John Babiak, Woll Matthew G, Hongyan Qi, Nikolai Naryshkin, Manaswini Sivaramakrishnan, Lee L. Rubin, Jana Narasimhan, Neil Gregory Almstead, Vijayalakshmi Gabbeta, Amal Dakka, Loren A. Eng, Xin Zhao, Nicole Risher, Young-Choon Moon, Marla Weetall, Jiyuan Ma, Karen K. Y. Ling, Stuart W. Peltz, Ellen Welch, Friedrich Metzger, Guangming Chen, Bansri Furia, Daniel Haehnke, Ronald Kong, Anirvan Ghosh, Xiaoyan Zhang, Karen S. Chen
Publikováno v:
Science. 345:688-693
Drugs that provide the splice of life Motor neurons relay signals from the nervous system to muscle fibers. In patients with spinal muscular atrophy, a protein required for the survival of these neurons is deficient or missing altogether, so the neur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee00322a0f82a8e7897ded171950628b
https://doi.org/10.1126/science.1250127
https://doi.org/10.1126/science.1250127
Autor:
Zhang, Nanjing, Turpoff, Anthony, Zhang, Xiaoyan, Huang, Song, Liu, Yalei, Almstead, Neil, Njoroge, F. George, Gu, Zhengxian, Graci, Jason, Jung, Stephen P., Pichardo, John, Colacino, Joseph, Lahser, Fred, Ingravallo, Paul, Weetall, Marla, Nomeir, Amin, Karp, Gary M.
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 15 January 2016 26(2):594-601
Autor:
Connie Freund, Neil Gregory Almstead, Alexander Arefolov, Jamie Breslin, Gary Mitchell Karp, Guangming Chen, Marla Weetall, Anthony Turpoff, Hongyu Ren, Joseph M. Colacino, Richard G. Wilde, Atiyya Khan, Takashi Komatsu, James J. Takasugi, Zhengxian Gu, Jean Hedrick
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:3942-3946
A series of novel 2-phenylindole analogs were synthesized and evaluated for activity in subgenomic HCV replicon inhibition assays. Several compounds containing small alkyl sulfonamides on the phenyl ring exhibiting submicromolar EC50 values against t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1eb62f8bca18ec60186985b95f72758
https://doi.org/10.1016/j.bmcl.2013.04.050
https://doi.org/10.1016/j.bmcl.2013.04.050
Autor:
Yalei Liu, Valerie Clausen, Amin A. Nomeir, Xiaoyan Zhang, Christie Morrill, William Joseph Lennox, Anthony Turpoff, Zhengxian Gu, Takashi Komatsu, Christine Espiritu, Neil Gregory Almstead, F. George Njoroge, Gary Mitchell Karp, Guangming Chen, Steven D. Paget, Joseph M. Colacino, Hongyu Ren, Chunshi Li, Jin Zhu, Jason D. Graci, Nanjing Zhang, Nicole Risher, Frederick C. Lahser, Marla Weetall, James J. Takasugi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:3947-3953
A novel series of 6-(indol-2-yl)pyridine-3-sulfonamides was prepared and evaluated for their ability to inhibit HCV RNA replication in the HCV replicon cell culture assay. Preliminary optimization of this series furnished compounds with low nanomolar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7637387fd6f4b0f3d5c90b600082ee8
https://doi.org/10.1016/j.bmcl.2013.04.049
https://doi.org/10.1016/j.bmcl.2013.04.049
Autor:
Woll Matthew G, Neil Gregory Almstead, Ellen Welch, Nicole Risher, Vijayalakshmi Gabbeta, Tianle Yang, Marla Weetall, Hongyan Qi, Nikolai Naryshkin, Jana Narasimhan, Song Huang, Chang-Sun Lee, Nanjing Zhang, Gary Mitchell Karp, Xin Zhao, Guangming Chen, Young-Choon Moon, Amal Dakka, Soongyu Choi, Xiaoyan Zhang, Anthony Turpoff, Chunshi Li, Josephine Sheedy
Publikováno v:
Journal of medicinal chemistry. 59(13)
The underlying cause of spinal muscular atrophy (SMA) is a deficiency of the survival motor neuron (SMN) protein. Starting from hits identified in a high-throughput screening campaign and through structure-activity relationship investigations, we hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec737e85d7408e45621d41586a1a4757
https://pubmed.ncbi.nlm.nih.gov/27299569
https://pubmed.ncbi.nlm.nih.gov/27299569
Autor:
Chen, Guangming, Ren, Hongyu, Zhang, Nanjing, Lennox, William, Turpoff, Anthony, Paget, Steven, Li, Chunshi, Almstead, Neil, Njoroge, F. George, Gu, Zhengxian, Graci, Jason, Jung, Stephen P., Colacino, Joseph, Lahser, Fred, Zhao, Xin, Weetall, Marla, Nomeir, Amin, Karp, Gary M.
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 15 February 2015 25(4):781-786
Autor:
James J. Takasugi, Anna Mollin, Jeffrey Allen Campbell, Meenal Patel, Shirley Yeh, Stuart W. Peltz, Yuki Tomizawa, Young-Choon Moon, Ellen Welch, Allan Jacobson, Gary Mitchell Karp, Huisheng Feng, Anthony Turpoff, Hongyu Ren, Jin Zhuo, S. M. Jones, Atiyya Khan, Valerie Northcutt, Neil G. Almstead, Arthur Branstrom, Feng He, M. Morgan Conn, Guangming Chen, William D. Ju, Wilde Richard Gerald, Samit Hirawat, Christopher R. Trotta, Masataka Kawana, Nicole Risher, Sergey Paushkin, Seongwoo Hwang, Joseph M. Colacino, H. Lee Sweeney, Donald Thomas Corson, Phyllis Spatrick, Elisabeth R. Barton, Panayiota Trifillis, Langdon L. Miller, Westley J. Friesen, Marla Weetall, John Babiak, Jean Hedrick
Publikováno v:
Nature. 447:87-91
Nonsense mutations promote premature translational termination and cause anywhere from 5-70% of the individual cases of most inherited diseases. Studies on nonsense-mediated cystic fibrosis have indicated that boosting specific protein synthesis from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::842e3830493226719ef5b397161007f5
https://doi.org/10.1038/nature05756
https://doi.org/10.1038/nature05756