Zobrazeno 1 - 10
of 35
pro vyhledávání: '"A. Tudor Evans"'
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-14 (2021)
Abstract The synthesis of new proteins is a fundamental aspect of cellular life and is required for many neurological processes, including the formation, updating and extinction of long-term memories. Protein synthesis is impaired in neurodegenerativ
Externí odkaz:
https://doaj.org/article/4127815f43ac4aa0bd01fb124c002f62
Publikováno v:
eLife, Vol 9 (2020)
The formation of spatial long-term memory (LTM) requires the de novo synthesis of distinct sets of proteins; however, a non-biased examination of the de novo proteome in this process is lacking. Here, we generated a novel mouse strain, which enables
Externí odkaz:
https://doaj.org/article/4bf7275afe1944a6a17845019d94dfb7
Autor:
Wendy Lee, Nghia Q. Nguyen, Jürgen Götz, Fabrice R. Turpin, Tishila Palliyaguru, Pankaj Sah, Daniel G. Blackmore, Perry F. Bartlett, Harrison Tudor Evans, Matthew Pelekanos, Antony Chicoteau, Jae Song, Robert K. P. Sullivan
Publikováno v:
Molecular Psychiatry
Advanced physiological aging is associated with impaired cognitive performance and the inability to induce long-term potentiation (LTP), an electrophysiological correlate of memory. Here, we demonstrate in the physiologically aged, senescent mouse br
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d516263307f33d2c8d2191bb421ed580
https://doi.org/10.1038/s41380-021-01129-7
https://doi.org/10.1038/s41380-021-01129-7
Autor:
Jürgen Götz, Bradley T. Hyman, Harrison Tudor Evans, Rachel E. Bennett, Sevannah A. Ellis, Joseph Benetatos, Liviu-Gabriel Bodea
Publikováno v:
Acta Neuropathologica
Phosphatase and tensin homolog (PTEN) regulates synaptic density in development; however, whether PTEN also regulates synapse loss in a neurodegenerative disorder such as frontotemporal lobar degeneration with Tau deposition (FTLD-Tau) has not been e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8880180dc993b7ecbaeaf0f53153c88
https://doi.org/10.1007/s00401-020-02151-9
https://doi.org/10.1007/s00401-020-02151-9
Publikováno v:
Acta Neuropathologica Communications
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-14 (2021)
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-14 (2021)
The synthesis of new proteins is a fundamental aspect of cellular life and is required for many neurological processes, including the formation, updating and extinction of long-term memories. Protein synthesis is impaired in neurodegenerative disease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39c447bad1540bd05d9fd17ddbd685a9
http://europepmc.org/articles/PMC8214309
http://europepmc.org/articles/PMC8214309
Publikováno v:
Alzheimer's & Dementia. 16
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ebeb186b58b6026a13d58593369e5b5
https://doi.org/10.1002/alz.038895
https://doi.org/10.1002/alz.038895
Publikováno v:
Brain research bulletin. 169
Memory formation is a fundamental function of the nervous system that enables the experience-based adaptation of behaviour. The formation, recall and updating of long-term memory (LTM) requires new protein synthesis through its direct involvement in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3b6fe4c13dfcafec512b805bd3a0a39
https://pubmed.ncbi.nlm.nih.gov/33465403
https://pubmed.ncbi.nlm.nih.gov/33465403
Autor:
Harrison Tudor Evans
The synthesis of new proteins is fundamental for sustaining cellular life, with the dynamic and controlled regulation of this molecular process allowing cells to respond to a wide range of stimuli. In neurons, de novo protein synthesis occurs to vary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4635140ba8af8d96d4ff3594050fb95
https://doi.org/10.14264/uql.2020.938
https://doi.org/10.14264/uql.2020.938
Publikováno v:
eLife
eLife, Vol 9 (2020)
eLife, Vol 9 (2020)
The formation of spatial long-term memory (LTM) requires the de novo synthesis of distinct sets of proteins; however, a non-biased examination of the de novo proteome in this process is lacking. Here, we generated a novel mouse strain, which enables
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::533e9d997a368d088abbc1714b4d6774
https://doi.org/10.7554/elife.52990
https://doi.org/10.7554/elife.52990
Autor:
Rebecca M. Nisbet, Phillip W. Janowicz, Anneke Van der Jeugd, Harrison Tudor Evans, Gerhard Leinenga, Jürgen Götz
Publikováno v:
Brain
One of the greatest challenges for the treatment of neurodegenerative disease is crossing the blood-brain barrier. Nisbet et al. demonstrate that non-invasive scanning ultrasound increases the delivery of tau-specific single-chain antibody fragments
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c0176eb2658d2affc1b257b4f3b1ad3
https://doi.org/10.1093/brain/awx052
https://doi.org/10.1093/brain/awx052