Zobrazeno 1 - 10
of 449
pro vyhledávání: '"A. Trauzold"'
Autor:
Nourhane Ammar, Maya Hildebrandt, Claudia Geismann, Christian Röder, Timo Gemoll, Susanne Sebens, Ania Trauzold, Heiner Schäfer
Publikováno v:
Antioxidants, Vol 12, Iss 10, p 1818 (2023)
Metabolic compartmentalization of stroma-rich tumors, like pancreatic ductal adenocarcinoma (PDAC), greatly contributes to malignancy. This involves cancer cells importing lactate from the microenvironment (reverse Warburg cells) through monocarboxyl
Externí odkaz:
https://doaj.org/article/3f337b46b0c8422fa790dcd023bbceb6
Autor:
Anna Willms, Hella Schupp, Michelle Poelker, Alshaimaa Adawy, Jan Frederik Debus, Torsten Hartwig, Tim Krichel, Jürgen Fritsch, Steven Singh, Henning Walczak, Silvia von Karstedt, Heiner Schäfer, Anna Trauzold
Publikováno v:
Cell Death and Disease, Vol 12, Iss 8, Pp 1-12 (2021)
Abstract TNF-related apoptosis-inducing ligand (TRAIL) receptor 2 (TRAIL-R2) can induce apoptosis in cancer cells upon crosslinking by TRAIL. However, TRAIL-R2 is highly expressed by many cancers suggesting pro-tumor functions. Indeed, TRAIL/TRAIL-R2
Externí odkaz:
https://doaj.org/article/01faaca6a4584d9ebb8d543b9bdea437
Publikováno v:
In Hepatobiliary & Pancreatic Diseases International June 2021 20(3):279-284
Autor:
Anna-Christina Rambow, Insa Aschenbach, Sofie Hagelund, Doaa Tawfik, Jan-Paul Gundlach, Sebastian Weiße, Nicolai Maass, Anna Trauzold
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Binding of TRAIL to its death domain-containing receptors TRAIL-R1 and TRAIL-R2 can induce cell death and/or pro-inflammatory signaling. The importance of TRAIL and TRAIL-R1/R2 in tumor immune surveillance and cancer biology has meanwhile been well d
Externí odkaz:
https://doaj.org/article/df98f6fc26e5461cab7571c46261e202
Autor:
Doaa Tawfik, Angela Zaccagnino, Alexander Bernt, Monika Szczepanowski, Wolfram Klapper, Albrecht Schwab, Holger Kalthoff, Anna Trauzold
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-17 (2020)
Abstract Background The human pancreatic cancer cell line A818–6 can be grown in vitro either as a highly malignant, undifferentiated monolayer (ML) or as three-dimensional (3D) single layer hollow spheres (HS) simulating a benign, highly different
Externí odkaz:
https://doaj.org/article/9b656db7e86545e5ae1471a8147f4dac
Autor:
Sofie Hagelund, Anna Trauzold
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is an important mediator of tumor immune surveillance. In addition, its potential to kill cancer cells without harming healthy cells led to the development of TRAIL receptor agonists, wh
Externí odkaz:
https://doaj.org/article/7943b2f2696546b3b966c533fa986c05
Akademický článek
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Autor:
Jan-Paul Gundlach, Charlotte Hauser, Franka Maria Schlegel, Christine Böger, Christian Röder, Christoph Röcken, Thomas Becker, Jan-Hendrik Egberts, Holger Kalthoff, Anna Trauzold
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-10 (2018)
Abstract Background The death receptors TRAIL-R1 and TRAIL-R2 are frequently overexpressed in cancer and there is an emerging evidence for their important role in malignant progression, also in the case of pancreatic ductal adenocarcinoma (PDAC). In
Externí odkaz:
https://doaj.org/article/fd93353d1fe04da2993bd5d883b6cc32
Autor:
Doaa Tawfik, Christopher Groth, Jan-Paul Gundlach, Matthias Peipp, Dieter Kabelitz, Thomas Becker, Hans-Heinrich Oberg, Anna Trauzold, Daniela Wesch
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Acquired immune evasion is one of the mechanisms that contributes to the dismal prognosis of cancer. Recently, we observed that different γδ T cell subsets as well as CD8+ αβ T cells infiltrate the pancreatic tissue. Interestingly, the abundance
Externí odkaz:
https://doaj.org/article/399e84bdb6fa467f9f93ff983e3eb50a
Autor:
Anna Willms, Hella Schittek, Sascha Rahn, Justyna Sosna, Ufuk Mert, Dieter Adam, Anna Trauzold
Publikováno v:
PLoS ONE, Vol 14, Iss 4, p e0214847 (2019)
Due to their ability to preferentially induce cell death in tumor cells, while sparing healthy cells, TNF-related apoptosis-inducing ligand (TRAIL) and agonistic anti-TRAIL-R1 or anti-TRAIL-R2-specific antibodies are under clinical investigations for
Externí odkaz:
https://doaj.org/article/b399ac7566e0450e9157f35b7a9e1750