Cytotoxic T cells are able to efficiently eliminate cancer cells by additive cytotoxicity

Autor: Bettina Weigelin, Annemieke Th. den Boer, Esther Wagena, Kelly Broen, Harry Dolstra, Rob J. de Boer, Carl G. Figdor, Johannes Textor, Peter Friedl

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)

Cytotoxic CD8+ T lymphocytes (CTL) often fail to kill tumour cells in one-to-one interactions. Here the authors show that these sublethal interactions from multiple CTL can add up over time and achieve tumour cell killing by additive cytotoxicity.

Externí odkaz: https://doaj.org/article/62213730d2074330a309addcd60ee54f

Cancer cell elimination by cytotoxic T cell cooperation and additive damage

Autor: Kelly Broen, Annemieke Th den Boer, Rob J. de Boer, Carl G. Figdor, Esther Wagena, Peter Friedl, Bettina Weigelin, Johannes Textor, Harry Dolstra

SummaryCytotoxic T lymphocytes (CTL) eliminate tumor target cells in an antigen and cell-contact dependent manner. Lethal hit delivery occurs as a rapid and binary, “yes/no” process when immunogenicity is very high1–3, however in vivo CTL often

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::872126135328cb8ce7f28f2b79600527

CD4+ T Cells Are Able to Promote Tumor Growth through Inhibition of Tumor-Specific CD8+ T-Cell Responses in Tumor-Bearing Hosts

Autor: René E. M. Toes, Geertje J. D. van Mierlo, Cornelis J. M. Melief, Rienk Offringa, Marieke F. Fransen, Annemieke Th. den Boer

Publikováno v: Cancer Research. 65:6984-6989

Modulation of the immune response by established tumors may contribute to the limited success of therapeutic vaccination for the treatment of cancer compared with vaccination in a preventive setting. We analyzed the contribution of the CD4+ T-cell po

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1023a90590613eb27a436af2a92950d5
https://doi.org/10.1158/0008-5472.can-04-3344

The Tumoricidal Activity of Memory CD8+ T Cells Is Hampered by Persistent Systemic Antigen, but Full Functional Capacity Is Regained in an Antigen-Free Environment

Autor: Annemieke Th. den Boer, René E. M. Toes, Marieke F. Fransen, Geertje J. D. van Mierlo, Rienk Offringa, Cornelis J. M. Melief

Publikováno v: The Journal of Immunology. 172:6074-6079

Naive T cells can be tolerized in the periphery by diverse mechanisms. However, the extent to which memory T cells are susceptible to tolerance induction is less well defined. Vaccination of mice with a minimal CTL epitope derived from human adenovir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e7244d14e32227e50a4adc233a21aeb
https://doi.org/10.4049/jimmunol.172.10.6074

Prevention of the metabolic syndrome in IGT subjects in a lifestyle intervention: Results from the SLIM study

Autor: Edith J. M. Feskens, Jos H. C. H. Stegen, Eva Corpeleijn, C. Roumen, Ellen E. Blaak, I.J.T. Herraets, A. Th. den Boer, Nicolaas C. Schaper

Publikováno v: Nutrition Metabolism and Cardiovascular Diseases, 23(11), 1147-1153. ELSEVIER SCI LTD
Nutrition, Metabolism & Cardiovascular Diseases 23 (2013)
Nutrition, Metabolism & Cardiovascular Diseases, 23, 1147-1153
Nutrition, Metabolism and Cardiovascular Diseases, 23(11), 1147-1153. ELSEVIER SCI LTD

Background and aims: The Study on Lifestyle intervention and Impaired glucose tolerance Maastricht (SLIM), a randomized controlled trial, directed at diet and physical activity in impaired glucose tolerant subjects was effective to improve glucose to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8271de23de301d2c60627013d75fecde
https://cris.maastrichtuniversity.nl/en/publications/ed7b4252-dc5d-4b80-8d82-2e06d7ed684e