Zobrazeno 1 - 10
of 938
pro vyhledávání: '"A. T. MacDonald"'
Autor:
Qiuyu Martin Zhu, Yu-Han H. Hsu, Frederik H. Lassen, Bryan T. MacDonald, Stephanie Stead, Edyta Malolepsza, April Kim, Taibo Li, Taiji Mizoguchi, Monica Schenone, Gaelen Guzman, Benjamin Tanenbaum, Nadine Fornelos, Steven A. Carr, Rajat M. Gupta, Patrick T. Ellinor, Kasper Lage
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-15 (2024)
Abstract Population-based association studies have identified many genetic risk loci for coronary artery disease (CAD), but it is often unclear how genes within these loci are linked to CAD. Here, we perform interaction proteomics for 11 CAD-risk gen
Externí odkaz:
https://doaj.org/article/33f24fe85b5e427da89e1cdd0af7dd9f
Autor:
Polychronis Pavlidis, Anastasia Tsakmaki, Eirini Pantazi, Katherine Li, Domenico Cozzetto, Jonathan Digby- Bell, Feifei Yang, Jonathan W. Lo, Elena Alberts, Ana Caroline Costa Sa, Umar Niazi, Joshua Friedman, Anna K. Long, Yuchun Ding, Christopher D. Carey, Christopher Lamb, Mansoor Saqi, Matthew Madgwick, Leila Gul, Agatha Treveil, Tamas Korcsmaros, Thomas T. Macdonald, Graham M. Lord, Gavin Bewick, Nick Powell
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Mechanisms of non-response to ustekinumab, a biologic targeting IL-23, are currently unclear. Here, the authors show that the transcriptional program regulated by IL-22, an IL-23 responsive cytokine, is enriched in patients with ulcerative colitis un
Externí odkaz:
https://doaj.org/article/09b1e8f2868c4b6694a41d33bf89af3b
Publikováno v:
npj Systems Biology and Applications, Vol 8, Iss 1, Pp 1-7 (2022)
Abstract Synthetic networks require complex intertwined genetic regulation often relying on transcriptional activation or repression of target genes. CRISPRi-based transcription factors facilitate the programmable modulation of endogenous or syntheti
Externí odkaz:
https://doaj.org/article/910724e32624468682f45dfa01157ca8
Autor:
Kevin J. Roberts, Marion F. Cubitt, Timothy M. Carlton, Lurdes Rodrigues-Duarte, Luana Maggiore, Ray Chai, Simon Clare, Katherine Harcourt, Thomas T. MacDonald, Keith P. Ray, Anna Vossenkämper, Michael R. West, J. Scott Crowe
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Anti-TNFα and anti-IL-23 antibodies are highly effective therapies for Crohn’s disease or ulcerative colitis in a proportion of patients. V56B2 is a novel bispecific domain antibody in which a llama-derived IL-23p19-specific domain antibo
Externí odkaz:
https://doaj.org/article/1e2fe779b63b4101b684f9f331edf0fd
Publikováno v:
Frontiers of Agricultural Science and Engineering, Vol 7, Iss 3, Pp 289-295 (2020)
Soils provide the structural support, water and nutrients for plants in nature and are considered to be the foundation of agriculture production. Improving soil quality and soil health has been advocated as the goal of soil management toward sustaina
Externí odkaz:
https://doaj.org/article/93ed33bed1a147aabbe62d0b877148a7
Autor:
Kelly T. Macdonald, Ricardo A. Mosquera, Aravind Yadav, Maria C. Caldas-Vasquez, Hina Emanuel, Kimberly Rennie
Publikováno v:
BMC Pediatrics, Vol 20, Iss 1, Pp 1-8 (2020)
Abstract Background Congenital central hypoventilation syndrome (CCHS) is a rare disorder characterized by respiratory system abnormalities, including alveolar hypoventilation and autonomic nervous system dysregulation. CCHS is associated with compro
Externí odkaz:
https://doaj.org/article/ea20bdc3ad2e4f958fec4cf752205359
Autor:
Diogenes L. Antille, Ben C. T. Macdonald, Aleni Uelese, Michael J. Webb, Jennifer Kelly, Seuseu Tauati, Uta Stockmann, Jeda Palmer, James R. F. Barringer
Publikováno v:
Soil Systems, Vol 7, Iss 1, p 21 (2023)
A progressive decline in soil fertility in taro (Colocasia esculenta L., Schott) production systems has contributed to reduced crop productivity and farm profitability, and is recognized to be a threat to soil nutrient and food security in Samoa. Evi
Externí odkaz:
https://doaj.org/article/efb5833bbc894982aee3b8bd828ab6d9
Autor:
S. Fowler, L. McLaughlin, S. Bridges, M. Robichaud, B. Ridgway, D. Reece, K. Song, L. Dalrymple, R. Sully, S. Nason, S. Rowland, T. MacDonald, W. Paine, A. Reiman
Publikováno v:
HemaSphere, Vol 6, Pp 1828-1829 (2022)
Externí odkaz:
https://doaj.org/article/abd3fc7135cc4285873f31a61dcf4a9f
Publikováno v:
Plants, Vol 11, Iss 10, p 1324 (2022)
Drought is an abiotic stress that decreases crop photosynthesis, growth, and yield. Ascorbic acid has been used as a seed preconditioning agent to help mitigate drought in some species, but not yet in broccoli (Brassica oleracea var. italica). The ob
Externí odkaz:
https://doaj.org/article/9d51eba495ea47b6890bec9e7350aad5
Autor:
Ben C. T. MACDONALD, James O. LATIMER, Graeme D. SCHWENKE, Gunasekhar NACHIMUTHU, Jonathan C. BAIRD
Publikováno v:
Journal of Cotton Research, Vol 1, Iss 1, Pp 1-10 (2018)
Abstract Fifty years of sustained investment in research and development has left the Australian cotton industry well placed to manage nitrogen (N) fertiliser. The average production in the Australian cotton industry today is greater than two tonnes
Externí odkaz:
https://doaj.org/article/8592f202476e4683915d54a25aaa73cd