Zobrazeno 1 - 10
of 419
pro vyhledávání: '"A. Sulahian"'
Autor:
Andrew M. Waters, Tala O. Khatib, Bjoern Papke, Craig M. Goodwin, G. Aaron Hobbs, J. Nathaniel Diehl, Runying Yang, A. Cole Edwards, Katherine H. Walsh, Rita Sulahian, James M. McFarland, Kevin S. Kapner, Thomas S.K. Gilbert, Clint A. Stalnecker, Sehrish Javaid, Anna Barkovskaya, Kajal R. Grover, Priya S. Hibshman, Devon R. Blake, Antje Schaefer, Katherine M. Nowak, Jennifer E. Klomp, Tikvah K. Hayes, Michelle Kassner, Nanyun Tang, Olga Tanaseichuk, Kaisheng Chen, Yingyao Zhou, Manpreet Kalkat, Laura E. Herring, Lee M. Graves, Linda Z. Penn, Hongwei H. Yin, Andrew J. Aguirre, William C. Hahn, Adrienne D. Cox, Channing J. Der
Publikováno v:
Cell Reports, Vol 35, Iss 13, Pp 109291- (2021)
Summary: To identify therapeutic targets for KRAS mutant pancreatic cancer, we conduct a druggable genome small interfering RNA (siRNA) screen and determine that suppression of BCAR1 sensitizes pancreatic cancer cells to ERK inhibition. Integrative a
Externí odkaz:
https://doaj.org/article/24ff658919d8494e80b28117e73c541b
Publikováno v:
Clinical Infectious Diseases, 2002 Apr 01. 34(7), 939-943.
Externí odkaz:
https://www.jstor.org/stable/4482999
Autor:
Belinda Wang, Elsa Beyer Krall, Andrew James Aguirre, Miju Kim, Hans Ragnar Widlund, Mihir Bhavik Doshi, Ewa Sicinska, Rita Sulahian, Amy Goodale, Glenn Spencer Cowley, Federica Piccioni, John Gerard Doench, David Edward Root, William Chun Hahn
Publikováno v:
Cell Reports, Vol 18, Iss 6, Pp 1543-1557 (2017)
Intrinsic resistance and RTK-RAS-MAPK pathway reactivation has limited the effectiveness of MEK and RAF inhibitors (MAPKi) in RAS- and RAF-mutant cancers. To identify genes that modulate sensitivity to MAPKi, we performed genome-scale CRISPR-Cas9 los
Externí odkaz:
https://doaj.org/article/be8a210ebb1a489e99d35a897dbf44e3
Autor:
Rita Sulahian, Jason J. Kwon, Katherine H. Walsh, Emma Pailler, Timothy L. Bosse, Maneesha Thaker, Diego Almanza, Joshua M. Dempster, Joshua Pan, Federica Piccioni, Nancy Dumont, Alfredo Gonzalez, Jonathan Rennhack, Behnam Nabet, John A. Bachman, Amy Goodale, Yenarae Lee, Mukta Bagul, Rosy Liao, Adrija Navarro, Tina L. Yuan, Raymond W.S. Ng, Srivatsan Raghavan, Nathanael S. Gray, Aviad Tsherniak, Francisca Vazquez, David E. Root, Ari J. Firestone, Jeff Settleman, William C. Hahn, Andrew J. Aguirre
Publikováno v:
Cell Reports, Vol 29, Iss 1, Pp 118-134.e8 (2019)
Summary: The mitogen-activated protein kinase (MAPK) pathway is a critical effector of oncogenic RAS signaling, and MAPK pathway inhibition may be an effective combination treatment strategy. We performed genome-scale loss-of-function CRISPR-Cas9 scr
Externí odkaz:
https://doaj.org/article/9a62a78ea0ee4966a7135dceb3c889af
SOX15 Governs Transcription in Human Stratified Epithelia and a Subset of Esophageal Adenocarcinomas
Autor:
Sulahian, Rita, Chen, Justina, Arany, Zoltan, Jadhav, Unmesh, Peng, Shouyong, Rustgi, Anil K., Bass, Adam J., Srivastava, Amitabh, Hornick, Jason L., Shivdasani, Ramesh A.
Publikováno v:
In Cellular and Molecular Gastroenterology and Hepatology November 2015 1(6):598-609
Autor:
Abby Sarkar, Aaron J. Huebner, Rita Sulahian, Anthony Anselmo, Xinsen Xu, Kyle Flattery, Niyati Desai, Carlos Sebastian, Mary Anna Yram, Katrin Arnold, Miguel Rivera, Raul Mostoslavsky, Roderick Bronson, Adam J. Bass, Ruslan Sadreyev, Ramesh A. Shivdasani, Konrad Hochedlinger
Publikováno v:
Cell Reports, Vol 16, Iss 7, Pp 1929-1941 (2016)
Sox2 expression marks gastric stem and progenitor cells, raising important questions regarding the genes regulated by Sox2 and the role of Sox2 itself during stomach homeostasis and disease. By using ChIP-seq analysis, we have found that the majority
Externí odkaz:
https://doaj.org/article/2fc60626765843bfa6b42d2078cf7ed4
Publikováno v:
In Blood 5 December 2013 122(24):3964-3972
Publikováno v:
Clinical Infectious Diseases, 2012 Aug 01. 55(3), 475-476.
Externí odkaz:
http://dx.doi.org/10.1093/cid/cis415
Autor:
Bergeron, Anne *, Porcher, Raphaël, Sulahian, Annie, de Bazelaire, Cédric, Chagnon, Karine, Raffoux, Emmanuel, Vekhoff, Anne, Cornet, Muriel, Isnard, Françoise, Brethon, Benoit, Lacroix, Claire, Poirot, Jean Louis, Bouges, Claire, Derouin, Francis, Tazi, Abdellatif, Ribaud, Patricia
Publikováno v:
In Blood 23 February 2012 119(8):1831-1837
Autor:
Jinhua Wang, Senthil Muthaswamy, Kevin M. Haigis, Rita Sulahian, Kenneth D. Westover, Emily J. Poulin, Ryoma Ohi, Sergio Espinosa, Shuning He, Taebo Sim, Lianbo Li, Miljan Kuljanin, Nathanael S. Gray, Yan Liu, Nam Doo Kim, Joseph D. Mancias, Ling Huang, Brian M. Wolpin, Charles Y. Lin, Andrew J. Aguirre, Srivatsan Raghavan, Nora Diéguez-Martínez, Radha L. Kalekar, Jost Vrabic Koren, Zeng Zhiyang, Fleur M. Ferguson, James D Vasta, Behnam Nabet, William C. Hahn, Raymond W.S. Ng, Cesear Corona, Wayne Harshbarger, Alan L. Leggett, Matthew B. Robers, A. Thomas Look, Jose M. Lizcano, Annan Yang
Publikováno v:
Nature chemical biology
Doublecortin like kinase 1 (DCLK1) is an understudied kinase that is upregulated in a wide range of cancers, including pancreatic ductal adenocarcinoma (PDAC). However, little is known about its potential as a therapeutic target. We used chemoproteom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a0e3c79de5a15f9fac24f15a81dc963
https://doi.org/10.1038/s41589-020-0506-0
https://doi.org/10.1038/s41589-020-0506-0