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Akademický článek

Nicotinamide riboside for peripheral artery disease: the NICE randomized clinical trial

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)

Abstract People with lower extremity peripheral artery disease (PAD) have increased oxidative stress, impaired mitochondrial activity, and poor walking performance. NAD+ reduces oxidative stress and is an essential cofactor for mitochondrial respirat

Externí odkaz: https://doaj.org/article/2c373f254eb346318d878694e2b1a44e

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Akademický článek

Study Design, Rationale, and Methodology for Promote Weight Loss in Patients With Peripheral Artery Disease Who Also Have Obesity: The PROVE Trial

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 17 (2023)

Background Overweight and obesity are associated with adverse functional outcomes in people with peripheral artery disease (PAD). The effects of weight loss in people with overweight/obesity and PAD are unknown. Methods The PROVE (Promote Weight Loss

Externí odkaz: https://doaj.org/article/dedc3a3df20047fdb71c52614e447d1f

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Akademický článek

Mitochondrial Complex Abundance, Mitophagy Proteins, and Physical Performance in People With and Without Peripheral Artery Disease

Autor: Anna Picca, Stephanie E. Wohlgemuth, Mary M. McDermott, Sunil K. Saini, Sudarshan Dayanidhi, Dongxue Zhang, Shujun Xu, Kate Kosmac, Lu Tian, Luigi Ferrucci, Robert L. Sufit, Emanuele Marzetti, Christiaan Leeuwenburgh

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 6 (2023)

Background Mitochondrial abnormalities exist in gastrocnemius muscle of people with peripheral artery disease (PAD). Whether abnormalities in mitochondrial biogenesis and autophagy are associated with greater ischemia or walking impairment in PAD is

Externí odkaz: https://doaj.org/article/82a2dbb6f46e478cbee4419a5234b337

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Akademický článek

Dysregulated Genes, MicroRNAs, Biological Pathways, and Gastrocnemius Muscle Fiber Types Associated With Progression of Peripheral Artery Disease: A Preliminary Analysis

Autor: Sunil K. Saini, Daniel Pérez‐Cremades, Henry S. Cheng, Kate Kosmac, Charlotte A Peterson, Lingyu Li, Lu Tian, Gengfu Dong, Kevin K. Wu, Brian Bouverat, Stephanie E. Wohlgemuth, Terence Ryan, Robert L. Sufit, Luigi Ferrucci, Mary M. McDermott, Christiaan Leeuwenburgh, Mark W. Feinberg

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 11, Iss 21 (2022)

Background Peripheral artery disease (PAD) is associated with gastrocnemius muscle abnormalities. However, the biological pathways associated with gastrocnemius muscle dysfunction and their associations with progression of PAD are largely unknown. Th

Externí odkaz: https://doaj.org/article/21587088378c47698ffa4d8ba378fcb0

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Akademický článek

Effects of Walking Exercise at a Pace With Versus Without Ischemic Leg Symptoms on Functional Performance Measures in People With Lower Extremity Peripheral Artery Disease: The LITE Randomized Clinical Trial

Autor: Michael M. Hammond, Bonnie Spring, W. Jack Rejeski, Robert Sufit, Michael H. Criqui, Lu Tian, Lihui Zhao, Shujun Xu, Melina R. Kibbe, Christiaan Leeuwenburgh, Todd Manini, Daniel E. Forman, Diane Treat‐Jacobson, Tamar S. Polonsky, Lydia Bazzano, Luigi Ferrucci, Jack Guralnik, Donald M. Lloyd‐Jones, Mary M. McDermott

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 11, Iss 15 (2022)

Background In people with peripheral artery disease, post hoc analyses of the LITE (Low Intensity Exercise Intervention in Peripheral Artery Disease) randomized trial were conducted to evaluate the effects of walking exercise at a pace inducing ische

Externí odkaz: https://doaj.org/article/d38fd05c7d7b44f8b4df9a9c7feee045

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