Zobrazeno 1 - 10
of 88
pro vyhledávání: '"A. Sue Menko"'
The involvement of caspases in the process of nuclear removal during lens fiber cell differentiation
Autor:
Rifah Gheyas, A. Sue Menko
Publikováno v:
Cell Death Discovery, Vol 9, Iss 1, Pp 1-12 (2023)
Abstract The terminal differentiation of lens fiber cells involves elimination of their organelles, which must occur while still maintaining their functionality throughout a lifetime. Removal of non-nuclear organelles is accomplished through inductio
Externí odkaz:
https://doaj.org/article/fcde7c42fd6c474b9a3a6c59a44609ce
Autor:
Rifah Gheyas, A. Sue Menko
Publikováno v:
STAR Protocols, Vol 4, Iss 4, Pp 102569- (2023)
Summary: The elimination of lens organelles during development, required for mature lens function, is an autophagy-dependent mechanism induced through suppression of PI3K signaling. Here, we present a protocol for investigating the signaling pathways
Externí odkaz:
https://doaj.org/article/22cb0e13cda0453ba3333fb6f1828e60
Autor:
A. Sue Menko
Publikováno v:
Autophagy Reports, Vol 1, Iss 1, Pp 238-241 (2022)
The elimination of organelles to create the lens organelle-free zone (OFZ) is a macroautophagy/autophagy-dependent mechanism that occurs without causing cell death. This process is essential to the ability of the lens to focus incoming images on the
Externí odkaz:
https://doaj.org/article/ba8c613aa6ef4e7ba49336c0bee22da4
Publikováno v:
Biomolecules, Vol 13, Iss 11, p 1615 (2023)
While the lens is an avascular tissue with an immune-privileged status, studies have now revealed that there are immune responses specifically linked to the lens. The response to lens injury, such as following cataract surgery, has been shown to invo
Externí odkaz:
https://doaj.org/article/d34821830d3e484f986883d87d7740b7
Publikováno v:
Biomolecules, Vol 13, Iss 7, p 1059 (2023)
Recurrent epithelial erosions develop in the cornea due to prior injury or genetic predisposition. Studies of recurrent erosions in animal models allow us to gain insight into how erosions form and are resolved. While slowing corneal epithelial cell
Externí odkaz:
https://doaj.org/article/0739ff64935746b38741c7ca1021eae9
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Hyaluronic Acid/Hyaluronan (HA) is a major component of the provisional matrix deposited by cells post-wounding with roles both in regulating cell migration to repair a wound and in promoting a fibrotic outcome to wounding. Both are mediated through
Externí odkaz:
https://doaj.org/article/cb22b7795116457e971c2ba23fce5410
Autor:
Janice L. Walker, Weihao Wang, Edith Lin, Alison Romisher, Meghan P. Bouchie, Brigid Bleaken, A. Sue Menko, Maria A. Kukuruzinska
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract The development of ductal structures during branching morphogenesis relies on signals that specify ductal progenitors to set up a pattern for the ductal network. Here, we identify cellular asymmetries defined by the F-actin cytoskeleton and
Externí odkaz:
https://doaj.org/article/d770138b20474128aeea4295fea71d22
Autor:
Lisa Brennan, M. Joseph Costello, J. Fielding Hejtmancik, A. Sue Menko, S. Amer Riazuddin, Alan Shiels, Marc Kantorow
Publikováno v:
Cells, Vol 12, Iss 3, p 475 (2023)
Recent evidence points to autophagy as an essential cellular requirement for achieving the mature structure, homeostasis, and transparency of the lens. Collective evidence from multiple laboratories using chick, mouse, primate, and human model system
Externí odkaz:
https://doaj.org/article/f83b2dbb3fe0441c8ec60673aa2156d8
Publikováno v:
Cells, Vol 11, Iss 21, p 3515 (2022)
To ensure proper wound healing it is important to elucidate the signaling cues that coordinate leader and follower cell behavior to promote collective migration and proliferation for wound healing in response to injury. Using an ex vivo post-cataract
Externí odkaz:
https://doaj.org/article/05a73ca23274436f93da6ec1974d5978
Autor:
A. Sue Menko, Janice L. Walker
Publikováno v:
Biomolecules, Vol 12, Iss 9, p 1181 (2022)
The signaling inputs that function to integrate biochemical and mechanical cues from the extracellular environment to alter the wound-repair outcome to a fibrotic response remain poorly understood. Here, using a clinically relevant post-cataract surg
Externí odkaz:
https://doaj.org/article/710e5baa745f4e6c9c2dc6dd1eff030b