Zobrazeno 1 - 10
of 59
pro vyhledávání: '"A. Sofia F. Oliveira"'
Autor:
A. Sofia F. Oliveira, Deborah K. Shoemark, Amaurys Avila Ibarra, Andrew D. Davidson, Imre Berger, Christiane Schaffitzel, Adrian J. Mulholland
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 139-147 (2022)
The SARS-CoV-2 spike protein is the first contact point between the SARS-CoV-2 virus and host cells and mediates membrane fusion. Recently, a fatty acid binding site was identified in the spike (Toelzer et al. Science 2020). The presence of linoleic
Externí odkaz:
https://doaj.org/article/7a4e5a4ce4ed4c9c9f8922f51cdeada1
Autor:
Kapil Gupta, Christine Toelzer, Maia Kavanagh Williamson, Deborah K. Shoemark, A. Sofia F. Oliveira, David A. Matthews, Abdulaziz Almuqrin, Oskar Staufer, Sathish K. N. Yadav, Ufuk Borucu, Frederic Garzoni, Daniel Fitzgerald, Joachim Spatz, Adrian J. Mulholland, Andrew D. Davidson, Christiane Schaffitzel, Imre Berger
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
BriSΔ, a SARS-CoV-2 variant from clinical isolate hCoV/England/02/2020, comprises a deletion in a spike cleavage site. The structure and molecular dynamics of this spike provides mechanistic insights into how the deletion modulates virus infectivity
Externí odkaz:
https://doaj.org/article/aca02d9ce50d4ddb8d2a53b3b352d716
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract ATP binding cassette (ABC) transporters employ ATP hydrolysis to harness substrate translocation across membranes. The Escherichia coli MalFGK2E maltose importer is an example of a type I ABC importer and a model system for this class of ABC
Externí odkaz:
https://doaj.org/article/4903ba4df38e4237b2705ccb0279e2a6
Autor:
Filipa V. Sena, Filipe M. Sousa, A. Sofia F. Oliveira, Cláudio M. Soares, Teresa Catarino, Manuela M. Pereira
Publikováno v:
Redox Biology, Vol 16, Iss , Pp 209-214 (2018)
Type-II NADH:quinone oxidoreductases (NDH-2s) are membrane proteins involved in respiratory chains and the only enzymes with NADH:quinone oxidoreductase activity expressed in Staphylococcus aureus (S. aureus), one of the most common causes of clinica
Externí odkaz:
https://doaj.org/article/9997e6de5296444b97c267ef620c0b67
Autor:
Deborah E. Daniels, Ivan Ferrer-Vicens, Joseph Hawksworth, Tatyana N. Andrienko, Elizabeth M. Finnie, Natalie S. Bretherton, Daniel C. J. Ferguson, A. Sofia. F. Oliveira, Jenn-Yeu A. Szeto, Marieangela C. Wilson, John N. Brewin, Jan Frayne
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract β-thalassemia is a prevalent genetic disorder causing severe anemia due to defective erythropoiesis, with few treatment options. Studying the underlying molecular defects is impeded by paucity of suitable patient material. In this study we
Externí odkaz:
https://doaj.org/article/9939683767224f40b2a842f9297fb596
Autor:
Leonor Guerra-Guimarães, Carla Pinheiro, Ana Sofia F. Oliveira, Andrea Mira-Jover, Javier Valverde, Fernanda A. de F. Guedes, Herlander Azevedo, Vitor Várzea, Antonio Jesús Muñoz Pajares
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract To explore the connection between chloroplast and coffee resistance factors, designated as SH1 to SH9, whole genomic DNA of 42 coffee genotypes was sequenced, and entire chloroplast genomes were de novo assembled. The chloroplast phylogeneti
Externí odkaz:
https://doaj.org/article/221df03167b94ce48445932b3a2442b3
Autor:
Leonor Guerra-Guimarães, Carla Pinheiro, Ana Sofia F. Oliveira, Andrea Mira-Jover, Javier Valverde, Fernanda A. de F. Guedes, Herlander Azevedo, Vitor Várzea, Antonio Jesús Muñoz Pajares
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-2 (2023)
Externí odkaz:
https://doaj.org/article/5caa12dfaf5a4fa480612dbbd68b8c8b
Autor:
William J Allen, Robin A Corey, Daniel W Watkins, A Sofia F Oliveira, Kiel Hards, Gregory M Cook, Ian Collinson
Publikováno v:
eLife, Vol 11 (2022)
Transport of proteins across and into membranes is a fundamental biological process with the vast majority being conducted by the ubiquitous Sec machinery. In bacteria, this is usually achieved when the SecY-complex engages the cytosolic ATPase SecA
Externí odkaz:
https://doaj.org/article/1b494683a74344b6a9b7e11b4db47ad9
Autor:
Ioannis Galdadas, Shen Qu, Ana Sofia F Oliveira, Edgar Olehnovics, Andrew R Mack, Maria F Mojica, Pratul K Agarwal, Catherine L Tooke, Francesco Luigi Gervasio, James Spencer, Robert A Bonomo, Adrian J Mulholland, Shozeb Haider
Publikováno v:
eLife, Vol 10 (2021)
Understanding allostery in enzymes and tools to identify it offer promising alternative strategies to inhibitor development. Through a combination of equilibrium and nonequilibrium molecular dynamics simulations, we identify allosteric effects and co
Externí odkaz:
https://doaj.org/article/7aac1beac51a40888c31f6d01e330204
Autor:
Leonor Guerra-Guimarães, Carla Pinheiro, Ana Sofia F. Oliveira, Andrea Mira-Jover, Javier Valverde, Fernanda Freitas Guedes, Herlander Azevedo, Vitor Várzea, Antonio Muñoz Pajares
To explore the connection between chloroplast and coffee resistance factors, designated as SH1 to SH9, the whole genome of 42 coffee genotypes was sequenced and de novo assembled. The chloroplast phylogenetic haplotype network clustered individuals p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f81cc60d566d5fc333e994ecf689f6aa
https://doi.org/10.21203/rs.3.rs-2833277/v1
https://doi.org/10.21203/rs.3.rs-2833277/v1