Zobrazeno 1 - 10
of 779
pro vyhledávání: '"A. Siegner"'
Autor:
Kirschner, Robin Jeanne, Micheler, Carina M., Zhou, Yangcan, Siegner, Sebastian, Hamad, Mazin, Glowalla, Claudio, Neumann, Jan, Rajaei, Nader, Burgkart, Rainer, Haddadin, Sami
The use of pointed or edged tools or objects is one of the most challenging aspects of today's application of physical human-robot interaction (pHRI). One reason for this is that the severity of harm caused by such edged or pointed impactors is less
Externí odkaz:
http://arxiv.org/abs/2404.04004
Autor:
Cassandra Falckenhayn, Agata Bienkowska, Jörn Söhle, Katrin Wegner, Guenter Raddatz, Boris Kristof, Dirk Kuck, Ralf Siegner, Ronny Kaufmann, Julia Korn, Sascha Baumann, Daniela Lange, Andreas Schepky, Henry Völzke, Lars Kaderali, Marc Winnefeld, Frank Lyko, Elke Grönniger
Publikováno v:
Frontiers in Aging, Vol 4 (2024)
Changes in DNA methylation patterning have been reported to be a key hallmark of aged human skin. The altered DNA methylation patterns are correlated with deregulated gene expression and impaired tissue functionality, leading to the well-known skin a
Externí odkaz:
https://doaj.org/article/41b18a4c3c734ca79c31cb048d5cc259
Autor:
Sebastian M. Siegner, Laura Ugalde, Alexandra Clemens, Laura Garcia-Garcia, Juan A. Bueren, Paula Rio, Mehmet E. Karasu, Jacob E. Corn
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Fanconi Anemia (FA) is caused by deficiencies in DNA repair, making it hard to correct. Here the authors report a therapeutic base editing strategy to address two of the most prevalent FANCA mutations in patient hematopoietic stem and progenitor cell
Externí odkaz:
https://doaj.org/article/b34d04260a9d44c482d4d4f6ce67b09e
Publikováno v:
Social Enterprise Journal, 2021, Vol. 17, Issue 4, pp. 584-603.
Externí odkaz:
http://www.emeraldinsight.com/doi/10.1108/SEJ-10-2020-0096
Autor:
Stein, Friederike, Drung, Dietmar, Fricke, Lukas, Scherer, Hansjörg, Hohls, Frank, Leicht, Christoph, Götz, Martin, Krause, Christian, Behr, Ralf, Pesel, Eckart, Pierz, Klaus, Siegner, Uwe, Ahlers, Franz-Josef, Schumacher, Hans W.
Publikováno v:
Appl. Phys. Lett. 107, 103501 (2015)
We report on high-accuracy measurements of quantized current, sourced by a tunable-barrier single-electron pump at frequencies $f$ up to $1$ GHz. The measurements were performed with a new picoammeter instrument, traceable to the Josephson and quantu
Externí odkaz:
http://arxiv.org/abs/1506.05965
Autor:
Nicholas Holzscheck, Cassandra Falckenhayn, Jörn Söhle, Boris Kristof, Ralf Siegner, André Werner, Janka Schössow, Clemens Jürgens, Henry Völzke, Horst Wenck, Marc Winnefeld, Elke Grönniger, Lars Kaderali
Publikováno v:
npj Aging and Mechanisms of Disease, Vol 7, Iss 1, Pp 1-13 (2021)
Abstract The development of ‘age clocks’, machine learning models predicting age from biological data, has been a major milestone in the search for reliable markers of biological age and has since become an invaluable tool in aging research. Howe
Externí odkaz:
https://doaj.org/article/777c395850e541569fc03b8d41e94be4
Autor:
Sebastian M. Siegner, Mehmet E. Karasu, Markus S. Schröder, Zacharias Kontarakis, Jacob E. Corn
Publikováno v:
BMC Bioinformatics, Vol 22, Iss 1, Pp 1-12 (2021)
Abstract Background The rapid expansion of the CRISPR toolbox through tagging effector domains to either enzymatically inactive Cas9 (dCas9) or Cas9 nickase (nCas9) has led to several promising new gene editing strategies. Recent additions include CR
Externí odkaz:
https://doaj.org/article/0a978ceebc854d2f843921067c29d8f5
Autor:
Mohadeseh Mehrabian, Xinzhu Wang, Shehab Eid, Bei Qi Yan, Mark Grinberg, Murdock Siegner, Christopher Sackmann, Muhammad Sulman, Wenda Zhao, Declan Williams, Gerold Schmitt-Ulms
Publikováno v:
PLoS ONE, Vol 17, Iss 7, p e0270915 (2022)
It is widely anticipated that a reduction of brain levels of the cellular prion protein (PrPC) can prolong survival in a group of neurodegenerative diseases known as prion diseases. To date, efforts to decrease steady-state PrPC levels by targeting t
Externí odkaz:
https://doaj.org/article/7a1cc03fda3b4e359203144996b58c86
Autor:
Fricke, Lukas, Wulf, Michael, Kaestner, Bernd, Hohls, Frank, Mirovsky, Philipp, Mackrodt, Brigitte, Dolata, Ralf, Weimann, Thomas, Pierz, Klaus, Siegner, Uwe, Schumacher, Hans W.
Publikováno v:
Phys. Rev. Lett. 112, 226803 (2014)
With the anticipated redefinition of the international system of units (SI) the base units will be linked to fundamental constants of nature [1]. As for the electrical base unit "Ampere", it will be linked to the elementary charge e, requiring a corr
Externí odkaz:
http://arxiv.org/abs/1312.5669
Autor:
Allende, Daniela, Dasarathy, Srinivasan, McCullough, Arthur J., Penumatsa, Revathi, Dasarathy, Jaividhya, Lavine, Joel E., Abdelmalek, Manal F., Bashir, Mustafa, Buie, Stephanie, Diehl, Anna Mae, Guy, Cynthia, Kigongo, Christopher, Kopping, Mariko, Malik, David, Piercy, Dawn, Chalasani, Naga, Cummings, Oscar W., Gawrieh, Samer, Ragozzino, Linda, Sandrasegaran, Kumar, Vuppalanchi, Raj, Brunt, Elizabeth M., Cattoor, Theresa, Carpenter, Danielle, Freebersyser, Janet, King, Debra, Lai, Jinping, Neuschwander-Tetri, Brent A., Siegner, Joan, Stewart, Susan, Torretta, Susan, Wriston, Kristina, Gonzalez, Maria Cardona, Davila, Jodie, Jhaveri, Manan, Kowdley, Kris V., Mukhtar, Nizar, Ness, Erik, Poitevin, Michelle, Quist, Brook, Soo, Sherilynn, Ang, Brandon, Behling, Cynthia, Bhatt, Archana, Loomba, Rohit, Middleton, Michael S., Sirlin, Claude, Akhter, Maheen F., Bass, Nathan M., Brandman, Danielle, Gill, Ryan, Hameed, Bilal, Maher, Jacqueline, Terrault, Norah, Ungermann, Ashley, Yeh, Matthew, Boyett, Sherry, Contos, Melissa J., Kirwin, Sherri, Luketic, Velimir A.C., Puri, Puneet, Sanyal, Arun J., Schlosser, Jolene, Siddiqui, Mohammad S., Yost-Schomer, Leslie, Fowler, Kathryn, Kleiner, David E., Doo, Edward C., Hall, Sherry, Hoofnagle, Jay H., Lee, Jessica J., Robuck, Patricia R., Sherker, Averell H., Torrance, Rebecca, Belt, Patricia, Clark, Jeanne M., Dodge, John, Donithan, Michele, Hallinan, Erin, Isaacson, Milana, Lazo, Mariana, Meinert, Jill, Miriel, Laura, Smith, Jacqueline, Smith, Michael, Sternberg, Alice, Tonascia, James, Van Natta, Mark L., Wagoner, Annette, Wilson, Laura A., Yamada, Goro, Yates, Katherine, Siddiqui, Mohammad Shadab, Van Natta, Mark, Neuschwander-Tetri, Brent
Publikováno v:
In Clinical Gastroenterology and Hepatology August 2019 17(9):1877-1885