Zobrazeno 1 - 10 of 510 pro vyhledávání: '"A. Sieders"'
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Akademický článek
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Akademický článek
EphA2 Is a Clinically Relevant Target for Breast Cancer Bone Metastatic Disease
Autor: David B Vaught, Alyssa R Merkel, Conor C Lynch, James Edwards, Mohammed Noor Tantawy, Timothy Hilliard, Shan Wang, Todd Peterson, Rachelle W Johnson, Julie A Sterling, Dana Brantley‐Sieders
Publikováno v: JBMR Plus, Vol 5, Iss 4, Pp n/a-n/a (2021)
ABSTRACT EphA2 receptor tyrosine kinase (RTK) is highly expressed in breast tumor cells across multiple molecular subtypes and correlates with poor patient prognosis. In this study, the potential role of EphA2 in this clinically relevant phenomenon i
Externí odkaz: https://doaj.org/article/e50828c08fb84f00868df19ee24dc038
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4
Akademický článek
Host deficiency in ephrin-A1 inhibits breast cancer metastasis [version 1; peer review: 2 approved]
Autor: Eileen Shiuan, Ashwin Inala, Shan Wang, Wenqiang Song, Victoria Youngblood, Jin Chen, Dana M. Brantley-Sieders
Publikováno v: F1000Research, Vol 9 (2020)
Background: The conventional dogma of treating cancer by focusing on the elimination of tumor cells has been recently refined to include consideration of the tumor microenvironment, which includes host stromal cells. Ephrin-A1, a cell surface protein
Externí odkaz: https://doaj.org/article/d77f234c236642d4b20c33c4c9dc8270
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5
Akademický článek
Lipophilic siRNA targets albumin in situ and promotes bioavailability, tumor penetration, and carrier-free gene silencing
Autor: Sarett, Samantha M., Werfel, Thomas A., Lee, Linus, Jackson, Meredith A., Kilchrist, Kameron V., Brantley-Sieders, Dana, Duvall, Craig L.
Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 2017 Aug 01. 114(32), E6490-E6497.
Externí odkaz: https://www.jstor.org/stable/26486943
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6
Akademický článek
Two distinct mTORC2-dependent pathways converge on Rac1 to drive breast cancer metastasis
Autor: Meghan Morrison Joly, Michelle M. Williams, Donna J. Hicks, Bayley Jones, Violeta Sanchez, Christian D. Young, Dos D. Sarbassov, William J. Muller, Dana Brantley-Sieders, Rebecca S. Cook
Publikováno v: Breast Cancer Research, Vol 19, Iss 1, Pp 1-15 (2017)
Abstract Background The importance of the mTOR complex 2 (mTORC2) signaling complex in tumor progression is becoming increasingly recognized. HER2-amplified breast cancers use Rictor/mTORC2 signaling to drive tumor formation, tumor cell survival and
Externí odkaz: https://doaj.org/article/398ec463dfb44d96a8fde76022898ffd
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7
Loss of Vascular Endothelial Glutaminase Inhibits Tumor Growth and Metastasis, and Increases Sensitivity to Chemotherapy
Autor: Verra M. Ngwa, Deanna N. Edwards, Yoonha Hwang, Breelyn Karno, Xiaoyong Wang, Chi Yan, Ann Richmond, Dana M. Brantley-Sieders, Jin Chen
Publikováno v: Cancer Res Commun
Glutamine is the most abundant nonessential amino acid in blood stream; yet its concentration in tumor interstitium is markedly lower than that in the serum, reflecting the huge demand of various cell types in tumor microenvironment for glutamine. Wh
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::520cf7085308d160b656b8aac02e9e6d
https://doi.org/10.1158/2767-9764.crc-22-0048
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Supplementary Fig. S6 from Loss of Vascular Endothelial Glutaminase Inhibits Tumor Growth and Metastasis, and Increases Sensitivity to Chemotherapy
Autor: Jin Chen, Dana M. Brantley-Sieders, Ann Richmond, Chi Yan, Xiaoyong Wang, Breelyn Karno, Yoonha Hwang, Deanna N. Edwards, Verra M. Ngwa
This figure shows volcano plots of differentially expressed genes in GLSECKO versus WT endothelial cell, differentially enriched pathways up and down, Gene set enrichment analysis, -log FPKM of Gls, Gls2, angiogenic genes, qRT-PCR of leptin and angio
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0328edceaa75e75bc86afc9796f3d7b4
https://doi.org/10.1158/2767-9764.22545422
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