Zobrazeno 1 - 10
of 2 409
pro vyhledávání: '"A. Shakhnovich"'
Autor:
Graff, David E., Pyzer-Knapp, Edward O., Jordan, Kirk E., Shakhnovich, Eugene I., Coley, Connor W.
Quantitative structure-property relationships (QSPRs) aid in understanding molecular properties as a function of molecular structure. When the correlation between structure and property weakens, a dataset is described as "rough," but this characteris
Externí odkaz:
http://arxiv.org/abs/2305.08238
Autor:
Loffredo, Emanuele, Vesconi, Elisabetta, Razban, Rostam, Peleg, Orit, Shakhnovich, Eugene, Cocco, Simona, Monasson, Rémi
Publikováno v:
Journal of Physics A: Mathematical and Theoretical, Volume 56, Number 45, Published 13 October 2023 Random Landscapes and Dynamics in Evolution, Ecology and Beyond
Understanding how a stressor applied on a biological system shapes its evolution is key to achieving targeted evolutionary control. Here we present a toy model of two interacting lattice proteins to quantify the response to the selective pressure def
Externí odkaz:
http://arxiv.org/abs/2303.12431
Autor:
Elizabeth J. Thompson, Angela Jeong, Victória E. Helfer, Valentina Shakhnovich, Andrea Edginton, Stephen J. Balevic, Laura P. James, David N. Collier, Ravinder Anand, Daniel Gonzalez, the Best Pharmaceuticals for Children Act – Pediatric Trials Network Steering Committee
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 8, Pp 1394-1408 (2024)
Abstract Pantoprazole is a proton pump inhibitor indicated for the treatment of gastroesophageal reflux disease, a condition that disproportionately affects children with obesity. Appropriately dosing pantoprazole in children with obesity requires un
Externí odkaz:
https://doaj.org/article/4ca30823adfe493396f3130d6019af5f
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract The existence of multiple biomolecular condensates inside living cells is a peculiar phenomenon not compatible with the predictions of equilibrium statistical mechanics. In this work, we address the problem of multiple condensates state (MCS
Externí odkaz:
https://doaj.org/article/9ffe34df61cb4ceb90892704ea5d0ade
Autor:
N. S. Kostritca, R. M. Rabinovich, R. M. Shakhnovich, I. S. Yavelov, R. G. Gulyan, Yu. K. Rytova, S. N. Tereschenko, A. D. Erlikh, D. V. Pevzner
Publikováno v:
Рациональная фармакотерапия в кардиологии, Vol 20, Iss 3, Pp 322-330 (2024)
Aim. To analyze the frequency, indications, and outcomes of using glycoprotein IIb/IIIa inhibitors in patients with acute myocardial infarction (AMI) in Russia based on data from a multicenter registry.Material and methods. This work is part of the R
Externí odkaz:
https://doaj.org/article/7b92a445311148e391030de5fc745b45
Mapping the space of photoswitchable ligands and photodruggable proteins with computational modeling
Light-activated drugs are a promising way to localize biological activity and minimize side effects. However, their development is complicated by the numerous photophysical and biological properties that must be simultaneously optimized. To accelerat
Externí odkaz:
http://arxiv.org/abs/2302.11490
Autor:
Kristina V. Orlova, Mikhail Iu. Fedyanin, Konstantin E. Simanenkov, Aleksandr S. Dergunov, Petr R. Goldshmidt, Aleksandra F. Saydullaeva, Darya V. Bogacheva, Marina A. Yavorskaya, Artur Z. Azanov, Alexander A. Fedenko, Larisa V. Bolotina, Tatyana I. Deshkina, Kseniya G. Babina, Ekaterina A. Kuzevanova, Liudmila G. Zhukova, Polina S. Feoktistova, Natalya I. Polshina, Ekaterina V. Peganova, Valentina E. Shikina, Maksim M. Sobolev, Oleg V. Mironov, Vera A. Vaschenko, Mariya M. Ershova, Agniya O. Mezhueva, Svetlana A. Orlova, Denis A. Tantsyrev, Darya K. Taskina, Antonina A. Teterich, Elena V. Karabina, Yuliya V. Kostalanova, Marina V. Bogacheva, Natalia V. Zhukova, Rashida V. Orlova, Maksim V. Zinkevich, Aleksandr I. Kazmin, Mikhail V. Volkonskiy, Liya M. Voronkova, Anastasiya S. Karpova, Mikhail L. Maleyko, Mariya N. Gorshenina, Elena I. Kryuchkova, Fedor V. Moiseenko, Yuliya I. Murzina, Shamil I. Musin, Andrey N. Ogloblin, Mariya S. Perminova, Regina A. Dumbrava, Sergey A. Emelyanov, Svetlana A. Protsenko, Alexander V. Sultanbaev, Anna V. Tarasova, Elena B. Shakhnovich, Marina V. Demchenkova, Yuliya A. Lozovskaya, Khedi S. Musaeva, Elena M. Pavlova, Roman A. Skotnikov, Vera V. Chernova, Angelina S. Chichkanova, Adina M. Akhmatova, Marina A. Zafirova, Andrey A. Mischenko, Elena N. Ovsienko, Viktoriya A. Petrukhnenko, Oksana A. Syusyukaylova, Yana A. Tyugina, Elena A. Shumilkina, Daniil L. Stroyakovskiy, Aleksandr N. Yurchenkov, Pavel L. Baldin, Anastasiya S. Belova, Olga V. Diduk, Elena A. Konovalova, Lyudmila N. Lebedeva, Yaroslav A. Li, Viktoriya V. Mashtapa, Yana A. Mironenkova, Kristina V. Narovenkova, Olga A. Pavlikova, Elvira L. Parsadanova, Irina S. Pimonova, Anna A. Ruzhnikova, Irina D. Sivunova, Ekaterina P. Soloveva, Maksim I. Sosnin, Kh. Toita Temirsultanova, Makhabbat Zh. Tyulegenova, Aleksandra V. Khodkevich, Nadezhda R. Shakurova, Sureya N. Efendieva, Karine L. Avagimyan, Ekaterina Р. Anokhina, Mariya I. Antoshkina, Stanislav M. Borzyanitsa, Samir K. Dzhentemirov, Marina V. Dmitrochenko, Alla V. Zheleznyak, Yuliya V. Komoza, Aleksandr S. Kopanev, Tatyana I. Kornienko, Margarita A. Krasilnikova, Darya A. Lukhmanova, Natalya S. Mazur, Polina M. Markina, Zhargal S. Mitapov, Svetlana N. Osodoeva, Irina A. Prokopenko, Irina M. Radyukova, Madina S. Ramazanova, Alfiya R. Safarova, Mariya A. Safronova, Khalimat M. Khabrieva, Natalya S. Tsygankova, Kseniya V. Chermakova, Tatyana A. Chirkova, Igor V. Samoylenko, Valeria V. Nazarova, Angelina E. Akhmetyanova, Lev V. Demidov
Publikováno v:
Современная онкология, Vol 26, Iss 1, Pp 20-34 (2024)
Background. Prior to the introduction of new agents — immune checkpoint inhibitors — for inoperable and/or metastatic melanoma (IMM), chemotherapy outcomes were generally poor. The median (Me) overall survival (OS) in IMM was no more than 6-9 mon
Externí odkaz:
https://doaj.org/article/fff40d04a39d498ba7ec6262154c7020
Molecular photoswitches are the foundation of light-activated drugs. A key photoswitch is azobenzene, which exhibits trans-cis isomerism in response to light. The thermal half-life of the cis isomer is of crucial importance, since it controls the dur
Externí odkaz:
http://arxiv.org/abs/2207.11592
Autor:
Marissa R. Keever-Keigher, Lisa Harvey, Veronica Williams, Carrie A. Vyhlidal, Atif A. Ahmed, Jeffery J. Johnston, Daniel A. Louiselle, Elin Grundberg, Tomi Pastinen, Craig A. Friesen, Rachel Chevalier, Craig Smail, Valentina Shakhnovich
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionChronic inflammation of the gastrointestinal tissues underlies gastrointestinal inflammatory disorders, leading to tissue damage and a constellation of painful and debilitating symptoms. These disorders include inflammatory bowel diseases
Externí odkaz:
https://doaj.org/article/a2f85ac5e21041d7ad71c85d212e9cff
Autor:
Serebryany, Eugene, Zhao, Victor Y., Park, Kibum, Bitran, Amir, Trauger, Sunia A., Budnik, Bogdan, Shakhnovich, Eugene I.
Non-native conformations drive protein misfolding diseases, complicate bioengineering efforts, and fuel molecular evolution. No current experimental technique is well-suited for elucidating them and their phenotypic effects. Especially intractable ar
Externí odkaz:
http://arxiv.org/abs/2204.06159