Zobrazeno 1 - 10
of 3 117
pro vyhledávání: '"A. Secker"'
Autor:
Adriano M. Gigante, Mohammad A. Hadis, Bailey Secker, Stephen C. Shaw, Paul R. Cooper, William M. Palin, Michael R. Milward, Robert J. Atterbury
Publikováno v:
Frontiers in Microbiology, Vol 15 (2024)
IntroductionPseudomonas aeruginosa is a leading cause of canine otitis externa. Enrofloxacin is often applied topically to treat this condition, although recalcitrant and recurring infections are common. There is evidence that exposure to blue light
Externí odkaz:
https://doaj.org/article/46d5b0f8d95c486c80510e3af5eaa6e3
Autor:
Philipp Trepte, Christopher Secker, Julien Olivet, Jeremy Blavier, Simona Kostova, Sibusiso B Maseko, Igor Minia, Eduardo Silva Ramos, Patricia Cassonnet, Sabrina Golusik, Martina Zenkner, Stephanie Beetz, Mara J Liebich, Nadine Scharek, Anja Schütz, Marcel Sperling, Michael Lisurek, Yang Wang, Kerstin Spirohn, Tong Hao, Michael A Calderwood, David E Hill, Markus Landthaler, Soon Gang Choi, Jean-Claude Twizere, Marc Vidal, Erich E Wanker
Publikováno v:
Molecular Systems Biology, Vol 20, Iss 4, Pp 428-457 (2024)
Abstract Protein–protein interactions (PPIs) offer great opportunities to expand the druggable proteome and therapeutically tackle various diseases, but remain challenging targets for drug discovery. Here, we provide a comprehensive pipeline that c
Externí odkaz:
https://doaj.org/article/bd1c8039d8764608818fd46023e76135
We reveal a significant spin-exchange pathway in the three-body recombination process for ultracold lithium-7 atoms near a zero-crossing of the two-body scattering length. This newly discovered recombination pathway involves the exchange of spin betw
Externí odkaz:
http://arxiv.org/abs/2107.11269
Publikováno v:
Phys. Rev. A 104, 023321 (2021)
We study zero-energy collisions between three identical bosons with spin $f = 1$ interacting via pairwise potentials. We quantify the corresponding three-body scattering hypervolumes, which parametrize the effective three-body interaction strengths i
Externí odkaz:
http://arxiv.org/abs/2105.04497
AI-guided pipeline for protein–protein interaction drug discovery identifies a SARS-CoV-2 inhibitor.
Autor:
Trepte, Philipp1,2 (AUTHOR) philipp.trepte@imba.oeaw.ac.at, Secker, Christopher1,3 (AUTHOR) secker@zib.de, Olivet, Julien4,5,6,7,8 (AUTHOR), Blavier, Jeremy4 (AUTHOR), Kostova, Simona1 (AUTHOR), Maseko, Sibusiso B4 (AUTHOR), Minia, Igor9 (AUTHOR), Silva Ramos, Eduardo1 (AUTHOR), Cassonnet, Patricia10 (AUTHOR), Golusik, Sabrina1 (AUTHOR), Zenkner, Martina1 (AUTHOR), Beetz, Stephanie1 (AUTHOR), Liebich, Mara J1 (AUTHOR), Scharek, Nadine1 (AUTHOR), Schütz, Anja11 (AUTHOR), Sperling, Marcel12 (AUTHOR), Lisurek, Michael13 (AUTHOR), Wang, Yang5,6,7 (AUTHOR), Spirohn, Kerstin5,6,7 (AUTHOR), Hao, Tong5,6,7 (AUTHOR)
Publikováno v:
Molecular Systems Biology. Apr2024, Vol. 20 Issue 4, p428-457. 30p.
Autor:
Christopher Secker, Konstantin Fackeldey, Marcus Weber, Sourav Ray, Christoph Gorgulla, Christof Schütte
Publikováno v:
Journal of Cheminformatics, Vol 15, Iss 1, Pp 1-14 (2023)
Abstract Opioids are essential pharmaceuticals due to their analgesic properties, however, lethal side effects, addiction, and opioid tolerance are extremely challenging. The development of novel molecules targeting the $$\mu$$ μ -opioid receptor (M
Externí odkaz:
https://doaj.org/article/2f2e637e46124f10bda45295a05767c3
Autor:
Anita Schmitt, Brigitte Neuber, Michael Schmitt, Melanie Märklin, Boris Klimovich, Claudia Lengerke, Emmanuelle Moraes Ribeiro, Kathy-Ann Secker, Ana-Maria Nitulescu, Rebekka Schairer, Hildegard Keppeler, Anton Wesle, Hannes Schmid, Daniela Chmiest, Silvia Podavini, Fulya Korkmaz, Corina Schneidawind, Dominik Schneidawind
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 1 (2024)
Background Relapse and graft-versus-host disease (GVHD) are the main causes of death after allogeneic hematopoietic cell transplantation (HCT). Preclinical murine models and clinical data suggest that invariant natural killer T (iNKT) cells prevent a
Externí odkaz:
https://doaj.org/article/2907d4c839b94d97ad13f309c1992704
Publikováno v:
Phys. Rev. A 103, 051303 (2021)
We study three-body collisions within ultracold mixtures with resonant interspecies $p$-wave interactions. Our results for the three-body effective interaction strength and decay rate are crucial towards understanding the stability and lifetime of th
Externí odkaz:
http://arxiv.org/abs/2012.10887
Publikováno v:
Phys. Rev. A 103, 052805 (2021)
We study Efimov physics of three identical bosons with pairwise multichannel interactions for Feshbach resonances of adjustable width. We find that the two-body multichannel nature of the interaction can affect the universal three-body spectrum, espe
Externí odkaz:
http://arxiv.org/abs/2011.14332
Publikováno v:
Phys. Rev. A 103, 022825 (2021)
We develop a full multichannel spin model in momentum space to investigate three-body recombination of identical alkali-metal atoms colliding in a magnetic field. The model combines the exact three-atom spin structure and realistic pairwise atom-atom
Externí odkaz:
http://arxiv.org/abs/2011.07943