Zobrazeno 1 - 10
of 5 849
pro vyhledávání: '"A. Schüle"'
Publikováno v:
JHEP 07 (2024) 072
We present a novel semi-analytical method for parton evolution. It is based on constructing a family of analytic functions spanning $x$-space which is closed under the considered evolution equation. Using these functions as a basis, the original inte
Externí odkaz:
http://arxiv.org/abs/2404.18667
Although database systems perform well in data access and manipulation, their relational model hinders data scientists from formulating machine learning algorithms in SQL. Nevertheless, we argue that modern database systems perform well for machine l
Externí odkaz:
http://arxiv.org/abs/2312.17355
Autor:
Alzahra Hamdan, Andrew C. Hooker, Xiaomei Chen, Andreas Traschütz, Rebecca Schüle, ARCA Study Group, EVIDENCE‐RND consortium, Matthis Synofzik, Mats O. Karlsson
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 8, Pp 1327-1340 (2024)
Abstract The Scale for the Assessment and Rating of Ataxia (SARA) is widely used for assessing the severity and progression of genetic cerebellar ataxias. SARA is now considered a primary end point in several ataxia treatment trials, but its underlyi
Externí odkaz:
https://doaj.org/article/ca2491fc5edd4d2f979817cba54b2637
Publikováno v:
Journal of High Energy Physics, Vol 2024, Iss 7, Pp 1-29 (2024)
Abstract We present a novel semi-analytical method for parton evolution. It is based on constructing a family of analytic functions spanning x-space which is closed under the considered evolution equation. Using these functions as a basis, the origin
Externí odkaz:
https://doaj.org/article/084de6ccc4ba4721a50c9c6268ca45c9
Autor:
Sheng Wang, Sebastian O. Klein, Sylvia Urban, Maximilian Staudt, Nicolas P. F. Barthes, Dominica Willmann, Johannes Bacher, Manuela Sum, Helena Bauer, Ling Peng, Georg A. Rennar, Christian Gratzke, Katrin M. Schüle, Lin Zhang, Oliver Einsle, Holger Greschik, Calum MacLeod, Christopher G. Thomson, Manfred Jung, Eric Metzger, Roland Schüle
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Inhibition of epigenetic regulators by small molecules is an attractive strategy for cancer treatment. Recently, we characterised the role of lysine methyltransferase 9 (KMT9) in prostate, lung, and colon cancer. Our observation that the enz
Externí odkaz:
https://doaj.org/article/dd0315952e94463cb2a9a88ac996f944
Autor:
Vita Brisnik, Jochen Vukas, Caroline Jung-Sievers, Karoline Lukaschek, G Caleb Alexander, Ulrich Thiem, Petra Thürmann, Cornelius Schüle, Sebastian Fischer, Erika Baum, Michael Drey, Sebastian Harder, Wilhelm Niebling, Ulrike Janka, Olaf Krause, Jochen Gensichen, Tobias Dreischulte, for the POKAL-Group
Publikováno v:
BMC Medicine, Vol 22, Iss 1, Pp 1-13 (2024)
Abstract Background Antidepressants are first-line medications for many psychiatric disorders. However, their widespread long-term use in some indications (e.g., mild depression and insomnia) is concerning. Particularly in older adults with comorbidi
Externí odkaz:
https://doaj.org/article/2fa20758b3a94d94bf93798a5f893b44
Autor:
Dominik Hermle, Robin Schubert, Pascal Barallon, Winfried Ilg, Rebecca Schüle, Ralf Reilmann, Matthis Synofzik, Andreas Traschütz
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 11, Iss 5, Pp 1097-1109 (2024)
Abstract Objective Voluntary upper limb movements are an ecologically important yet insufficiently explored digital‐motor outcome domain for trials in degenerative ataxia. We extended and validated the trial‐ready quantitative motor assessment ba
Externí odkaz:
https://doaj.org/article/4a078b67c3864f1a943793cde3c07521
Autor:
Kuan-Wei Peng, Allison Klotz, Arcan Guven, Unnati Kapadnis, Shobha Ravipaty, Vladimir Tolstikov, Vijetha Vemulapalli, Leonardo O. Rodrigues, Hongyan Li, Mark D. Kellogg, Farah Kausar, Linda Rees, Rangaprasad Sarangarajan, Birgitt Schüle, William Langston, Paula Narain, Niven R. Narain, Michael A. Kiebish
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-8 (2024)
Abstract Parkinson’s disease is a progressive neurodegenerative disorder in which loss of dopaminergic neurons in the substantia nigra results in a clinically heterogeneous group with variable motor and non-motor symptoms with a degree of misdiagno
Externí odkaz:
https://doaj.org/article/7ef1ad93078f4891b7305fd1f6d91e67
Vitamin D3 deficiency and osteopenia in spastic paraplegia type 5 indicate impaired bone homeostasis
Autor:
Sabrina Ehnert, Stefan Hauser, Holger Hengel, Philip Höflinger, Rebecca Schüle, Tobias Lindig, Jonathan Baets, Tine Deconinck, Peter de Jonghe, Tina Histing, Andreas K. Nüssler, Ludger Schöls, Tim W. Rattay
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract Hereditary spastic paraplegia type 5 (SPG5) is an autosomal recessively inherited movement disorder characterized by progressive spastic gait disturbance and afferent ataxia. SPG5 is caused by bi-allelic loss of function mutations in CYP7B1
Externí odkaz:
https://doaj.org/article/0838cc419332405ab3daed3ea2d41e47
Autor:
Paul Kriner, Peter Brieger, Oliver Pogarell, Cornelius Schüle, Lisa Mußmann, Julie Korbmacher, Florian Seemüller
Publikováno v:
Frontiers in Psychiatry, Vol 15 (2024)
ObjectivesPharmacotherapy of bipolar depression (BPD) is confronted with major clinical challenges, like limited evidence-based treatment options, regular cases of treatment resistance, and risk of treatment-emergent affective switches. Medical guide
Externí odkaz:
https://doaj.org/article/4d5ebc1c89b94c77b8ff3cc1c1dbc4dd