Výsledky vyhledávání - "A. S. Zhirnik"

Akademický článek

In vitro anticancer activity of folate-modified docetaxel-loaded PLGA nanoparticles against drug-sensitive and multidrug-resistant cancer cells

Autor: Yuri I. Poltavets, Alexander S. Zhirnik, Vasilisa V. Zavarzina, Yuliya P. Semochkina, Valentina G. Shuvatova, Anna A. Krasheninnikova, Sergey V. Aleshin, Danil O. Dronov, Eugeny A. Vorontsov, Vadim Yu. Balabanyan, Galina A. Posypanova

Publikováno v: Cancer Nanotechnology, Vol 10, Iss 1, Pp 1-17 (2019)

Abstract Background Poly(lactic-co-glycolic acid) (PLGA) is a biodegradable and biocompatible polymer which is widely used as a matrix to incorporate therapeutic agents. The anticancer activity of targeted folate-modified docetaxel-loaded PLGA nanopa

Externí odkaz: https://doaj.org/article/72e59fabf6d34ca99c237322db2e7599

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Improved Survival and Regeneration of Irradiated Mouse Neural Stem Cells after Co-Culturing with Non-Irradiated Mouse Neural Stem Cells or Mesenchymal Stem Cells from the Adipose Tissue

Autor: M. G. Ratushnyak, Yu. P. Semochkina, A. S. Zhirnik, O. D. Smirnova

Publikováno v: Bulletin of Experimental Biology and Medicine. 172:228-235

We studied the effect of neural stem cells (NSC) and mesenchymal stem cells (MSC) from mouse adipose tissue on survival, clonogenic activity, and senescence of NSC after exposure to γ-radiation. It was found that survival and clonogenic activity of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::97d27610c6c849447f3fd1e40722ee1c
https://doi.org/10.1007/s10517-021-05368-0

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Inhibition of DNA Double-Strand Break Repair by Niclosamide in Human Colorectal Cancer Cells

Autor: A. S. Zhirnik, E. Yu. Moskaleva, Yulia Semochkina

Publikováno v: Biology Bulletin. 46:1633-1640

The radiosensitizing effect of niclosamide against human rectal adenocarcinoma cells SW837 and human sigmoid colon carcinoma cells COLO 320 HSR and the underlying molecular mechanisms were investigated in this study. The survival rate of tumor cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a98499d679c6568bc0881fbd3c18c066
https://doi.org/10.1134/s1062359019120100

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Molecular mechanisms of antitumor activity of the polymeric form of niclosamide with respect to human colorectal cancer cells

Autor: E. Yu. Moskaleva, Yu. P. Semochkina, A. S. Zhirnik, E. A. Vorontsov, N. I. Krylov, I. A. Tubasheva, S. L. Kuznetsov

Publikováno v: Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry. 11:301-307

Using poly(lactic-co-glycolic) acid a polymeric form of niclosamide (PFN) has been developed and its antitumor activity against human colorectal cancer cell lines SW837, Caco-2, COLO 320 HSR has been investigated in comparison with free niclosamide.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9e8b55d26f780eaca3b6ecfce8964834
https://doi.org/10.1134/s1990750817030131

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Antineoplastic mechanisms of niclosamide-loaded nanoparticles in human colorectal cancer cells

Autor: E. Yu. Moskaleva, Yulia Semochkina, N. I. Krylov, I. A. Tubasheva, E. A. Vorontsov, A. S. Zhirnik, S. L. Kuznetsov

Publikováno v: Biomeditsinskaya Khimiya. 63:132-138

Using poly(lactic-co-glycolic) acid we developed a polymeric form of niclosamide (PFN) and investigated molecular mechanisms underlying its antitumor activity against human colorectal cancer cell lines (SW837, Caco-2, COLO 320 HSR). PFN was shown to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42044d948bbf39e8df7c88b462c5593a
https://doi.org/10.18097/pbmc20176302132

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Antiproliferative Activity of Niclosamide Against Melanoma and Colorectal Cancer Cells

Autor: A. S. Zhirnik, E. Yu. Moskaleva, V. G. Perevozchikova, S. E. Severin, Yu. P. Semochkina, A. D. Rodina

Publikováno v: Pharmaceutical Chemistry Journal. 50:471-474

Studies of the actions of niclosamide against tumor cells and normal human cells (human embryo kidney cells and pulmonary embryo fibroblast cells) showed higher levels of cytotoxic activity against tumor cells, including melanoma (the Mel-8, Mel-10,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::31d0b67d41b9f7efa5ff4f2849ab0922
https://doi.org/10.1007/s11094-016-1471-5

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Molecular mechanisms of antitumor activity of niclosamide

Autor: A. S. Zhirnik, E. Yu. Moskaleva, Severin Se, V. G. Perevozchikova

Publikováno v: Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry. 9:312-324

The review summarizes literature data on the antitumor activity of niclosamide and its molecular mechanisms. Earlier niclosamide was used for treatment of intestinal parasitic infections. Recent screening of various drugs and chemical compounds, aime

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bb0dcab01c63b494a255bf34e0369b60
https://doi.org/10.1134/s1990750815040022

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[Molecular mechanisms of niclosamide antitumor activity]

Autor: V. G. Perevozchikova, A. S. Zhirnik, E. Yu. Moskaleva, S E Severin

Publikováno v: Biomeditsinskaia khimiia. 61(6)

In this review the recent data regarding the antitumor activity of niclosamide and the molecular mechanisms of its antitumor activity are presented. Niclosamide has been used in the clinic for the treatment of intestinal parasite infections. In recen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3ef4f0c35e90330a2679e3ae5a73da3
https://pubmed.ncbi.nlm.nih.gov/26716739

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