TET2 lesions enhance the aggressiveness of CEBPA-mutant acute myeloid leukemia by rebalancing GATA2 expression

Autor: Elizabeth Heyes, Anna S. Wilhelmson, Anne Wenzel, Gabriele Manhart, Thomas Eder, Mikkel B. Schuster, Edwin Rzepa, Sachin Pundhir, Teresa D’Altri, Anne-Katrine Frank, Coline Gentil, Jakob Woessmann, Erwin M. Schoof, Manja Meggendorfer, Jürg Schwaller, Torsten Haferlach, Florian Grebien, Bo T. Porse

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)

Abstract The myeloid transcription factor CEBPA is recurrently biallelically mutated (i.e., double mutated; CEBPA DM) in acute myeloid leukemia (AML) with a combination of hypermorphic N-terminal mutations (CEBPA NT), promoting expression of the leuk

Externí odkaz: https://doaj.org/article/015f842398434c8ab9d3b64437bd9772

Androgen Receptors in Epithelial Cells Regulate Thymopoiesis and Recent Thymic Emigrants in Male Mice

Autor: Anna S. Wilhelmson, Marta Lantero Rodriguez, Inger Johansson, Elin Svedlund Eriksson, Alexandra Stubelius, Susanne Lindgren, Johan Bourghardt Fagman, Pamela J. Fink, Hans Carlsten, Olov Ekwall, Åsa Tivesten

Publikováno v: Frontiers in Immunology, Vol 11 (2020)

Androgens have profound effects on T cell homeostasis, including regulation of thymic T lymphopoiesis (thymopoiesis) and production of recent thymic emigrants (RTEs), i. e., immature T cells that derive from the thymus and continue their maturation t

Externí odkaz: https://doaj.org/article/c2281ddaa4364960ad5501dbbf1684ce

Testosterone is an endogenous regulator of BAFF and splenic B cell number

Autor: Anna S. Wilhelmson, Marta Lantero Rodriguez, Alexandra Stubelius, Per Fogelstrand, Inger Johansson, Matthew B. Buechler, Steve Lianoglou, Varun N. Kapoor, Maria E. Johansson, Johan B. Fagman, Amanda Duhlin, Prabhanshu Tripathi, Alessandro Camponeschi, Bo T. Porse, Antonius G. Rolink, Hans Nissbrandt, Shannon J. Turley, Hans Carlsten, Inga-Lill Mårtensson, Mikael C. I. Karlsson, Åsa Tivesten

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)

Testosterone deficiency is associated with autoimmunity and increased B cell numbers, but the underlying mechanism is unclear. Here the authors show that testosterone may modulate the production of B cell survival factor BAFF by fibroblastic reticula

Externí odkaz: https://doaj.org/article/d1f804563c204b959332c0cb6ac7f78d

TET2lesions enhance the aggressiveness ofCEBPA-mutant AML by rebalancingGATA2expression

Autor: Elizabeth Heyes, Anna S. Wilhelmson, Anne Wenzel, Gabriele Manhart, Thomas Eder, Mikkel B. Schuster, Edwin Rzepa, Sachin Pundhir, Teresa D’Altri, Coline Gentil, Manja Meggendorfer, Jürg Schwaller, Torsten Haferlach, Florian Grebien, Bo T. Porse

The myeloid transcription factor CEBPA is recurrently biallelically mutated (i.e., double mutated;CEBPADM) in acute myeloid leukemia (AML) with a combination of hypermorphic N-terminal mutations (CEBPANT), promoting expression of the leukemia-associa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::33ec7f896c881ee6889222b0683e4e87
https://doi.org/10.1101/2023.03.28.534511

CCAAT enhancer binding protein alpha (CEBPA) biallelic acute myeloid leukaemia: cooperating lesions, molecular mechanisms and clinical relevance

Autor: Anna S. Wilhelmson, Bo T. Porse

Publikováno v: British Journal of Haematology
Wilhelmson, A S & Porse, B T 2020, ' CCAAT enhancer binding protein alpha (CEBPA) biallelic acute myeloid leukaemia : cooperating lesions, molecular mechanisms and clinical relevance ', British Journal of Haematology, vol. 190, no. 4, pp. 495-507 . https://doi.org/10.1111/bjh.16534

Summary Recent advances in sequencing technologies have allowed for the identification of recurrent mutations in acute myeloid leukaemia (AML). The transcription factor CCAAT enhancer binding protein alpha (CEBPA) is frequently mutated in AML, and bi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82ab43b1e7027510c04f0d12369cf093
https://doi.org/10.1111/bjh.16534