Zobrazeno 1 - 10
of 216
pro vyhledávání: '"A. S. Widge"'
Publikováno v:
Frontiers in Psychiatry, Vol 13 (2022)
A major difficulty with treating psychiatric disorders is their heterogeneity: different neural causes can lead to the same phenotype. To address this, we propose describing the underlying pathophysiology in terms of interpretable, biophysical parame
Externí odkaz:
https://doaj.org/article/3f7d58157c294715b98bb7d81ec8d511
Autor:
A. S. Widge, S. Zorowitz, I. Basu, A. C. Paulk, S. S. Cash, E. N. Eskandar, T. Deckersbach, E. K. Miller, D. D. Dougherty
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Deep brain stimulation (DBS) is a promising treatment for psychiatric disorders, but its mechanism in relieving symptoms is unclear. Here, the authors show that DBS of ventral internal capsule/ventral striatum (VCVS) may act by enhancing prefrontal c
Externí odkaz:
https://doaj.org/article/7a591aa3e2644e31862b84ae5e1aa619
Publikováno v:
IEEE Access, Vol 12, Pp 113314-113335 (2024)
Extracting meaningful information from high-dimensional data poses a formidable modeling challenge, particularly when the data is obscured by noise or represented through different modalities. This research proposes a novel non-parametric modeling ap
Externí odkaz:
https://doaj.org/article/f42826521187497fa4a7a00052a4dd55
Autor:
Ryan D. Webler, Cristian Morales Carrasco, Samuel E. Cooper, Mo Chen, Christopher O. Hunt, Sierra Hennessy, Lancy Cao, Carol Lam, Allen Chiu, Cash Differding, Erin Todd, Timothy J. Hendrickson, Desmond J. Oathes, Alik S. Widge, Robert J.M. Hermosillo, Steven M. Nelson, Damien A. Fair, Shmuel M. Lissek, Ziad Nahas
Publikováno v:
Biological Psychiatry Global Open Science, Vol 4, Iss 3, Pp 100309- (2024)
Background: Fear overgeneralization is a promising pathogenic mechanism of clinical anxiety. A dominant model posits that hippocampal pattern separation failures drive overgeneralization. Hippocampal network–targeted transcranial magnetic stimulati
Externí odkaz:
https://doaj.org/article/d0a28a3eeb1c43a28376e122528f701d
Publikováno v:
eLife, Vol 10 (2021)
Brain rhythms have been proposed to facilitate brain function, with an especially important role attributed to the phase of low-frequency rhythms. Understanding the role of phase in neural function requires interventions that perturb neural activity
Externí odkaz:
https://doaj.org/article/4970fd0485364008b1cfad5f0975b186
Autor:
Frederick L. Hitti, Alik S. Widge, Patricio Riva-Posse, Donald A. Malone, Michael S. Okun, Maryam M. Shanechi, Kelly D. Foote, Sarah H. Lisanby, Elizabeth Ankudowich, Srinivas Chivukula, Edward F. Chang, Aysegul Gunduz, Clement Hamani, Ashley Feinsinger, Cynthia S. Kubu, Winston Chiong, Jennifer A. Chandler, Rafael Carbunaru, Binith Cheeran, Robert S. Raike, Rachel A. Davis, Casey H. Halpern, Nora Vanegas-Arroyave, Dejan Markovic, Sarah K. Bick, Cameron C. McIntyre, R. Mark Richardson, Darin D. Dougherty, Brian H. Kopell, Jennifer A. Sweet, Wayne K. Goodman, Sameer A. Sheth, Nader Pouratian
Publikováno v:
Brain Stimulation. 16:867-878
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a19d4ea4ca9cfe155bc9effbdc8de780
https://doi.org/10.1016/j.brs.2023.05.011
https://doi.org/10.1016/j.brs.2023.05.011
Autor:
Alik S. Widge
Publikováno v:
Harvard Review of Psychiatry. 31:162-171
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::211c773965bec3de9729f5b8f77f24e8
https://doi.org/10.1097/hrp.0000000000000367
https://doi.org/10.1097/hrp.0000000000000367
Publikováno v:
IEEE Transactions on Biomedical Engineering. 70:343-353
Internal physiological processes govern multiple state variables within the human body. Estimating these from point process-type bioelectric and biochemical observations is a challenge. Here we seek to estimate cortisol-related energy production and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::453eb6a955cae1aeb2357a7ae2b9a33a
https://doi.org/10.1109/tbme.2022.3191243
https://doi.org/10.1109/tbme.2022.3191243
Publikováno v:
Computational Psychiatry, Vol 1, Pp 58-81 (2017)
Censored data occur commonly in trial-structured behavioral experiments and many other forms of longitudinal data. They can lead to severe bias and reduction of statistical power in subsequent analyses. Principled approaches for dealing with censored
Externí odkaz:
https://doaj.org/article/87ea133aabe748c9a74dace2e9089312
Autor:
Alik S. Widge
Publikováno v:
Psychiatric Annals. 52:283-287
A large fraction of patients with mental disorders obtain no relief from medications, psychotherapy, or noninvasive treatments. For these patients, deep brain stimulation (DBS) may be an option. DBS is a surgical therapy that places electrodes precis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9f5844ab17ada83e334987f72f337b7
https://doi.org/10.3928/00485713-20220621-02
https://doi.org/10.3928/00485713-20220621-02