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Cardiac mitochondrial metabolism may contribute to differences in thermal tolerance of red- and white-blooded Antarctic notothenioid fishes

Autor: Kristin M. O'Brien, Rebekah Woolsey, Anthony P. Farrell, Karen Schlauch, Elizabeth L. Crockett, Anna S. Rix, Stuart Egginton, Megan Hoffman, Sean Merriman

Studies in temperate fishes provide evidence that cardiac mitochondrial function and the capacity to fuel cardiac work contribute to thermal tolerance. Here, we tested the hypothesis that decreased cardiac aerobic metabolic capacity contributes to th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b94c1d43e6b0ff2ad755c9ffa018f99c

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Hypoxia-Inducible Factor-1α in Antarctic notothenioids contains a polyglutamine and glutamic acid insert that varies in length with phylogeny

Autor: Theresa J. Grove, Kristin M. O'Brien, A. S. Rix

Publikováno v: Polar biology. 40(12)

The long evolution of the Antarctic perciform suborder of Notothenioidei in the icy, oxygen-rich waters of the Southern Ocean may have reduced selective pressure to maintain a hypoxic response. To test this hypothesis, cDNA of the key transcriptional

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc6e2b8958bc2e38214d9d5fa0115fed
https://pubmed.ncbi.nlm.nih.gov/29430077

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Obstacles to effective treatment of depression: a general practice perspective

Autor: Amanda Howe, A Hutchinson, R Telford, S Rix, R Jones

Publikováno v: Family Practice. 19:45-52

The Clinical Standards Advisory Group (CSAG) was asked by UK health ministers to advise on the standards of clinical care attainable for people with depression. The GP survey reported here is one part of a multicomponent UK-wide study of services for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72a849ca1168fcb001eaf0784b79513f
https://doi.org/10.1093/fampra/19.1.45

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Protocol for assessing services for people with severe mental illness

Autor: A Beadsmoore, Paul Lelliott, S Rix, R H Curtis, JK Wing

Publikováno v: British Journal of Psychiatry. 172:121-129

BackgroundThe Clinical Standards Advisory Group was asked by UK health ministers to advise on the standards of clinical care being achieved for people with schizophrenia. A subcommittee commissioned a review of standards, followed by research into ho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8748efa4b2e79c97b3ec554625550859
https://doi.org/10.1192/bjp.172.2.121

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Extraction of polar and nonpolar biomarkers from the martian soil using aqueous surfactant solutions

Autor: Mark R. Sims, Richard W. Court, Mark A. Sephton, Catherine S. Rix, David C. Cullen

The Life Marker Chip intends to use an aqueous surfactant solution to extract both polar AND nonpolar biomarkers from the martian soil for transport to an antibody-based detection system. Currently, a solution of 1.5 g l-1 polysorbate 80 in 20:80 (vo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04a329faf0519c244e351d8167fe5347
http://dspace.lib.cranfield.ac.uk/handle/1826/7474

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Immunological detection of small organic molecules in the presence of perchlorates: relevance to the life marker chip and life detection on Mars

Autor: Mark R. Sims, Catherine S. Rix, David C. Cullen

The proposed ExoMars mission, due to launch in 2018, aims to look for evidence of extant and extinct life in martian rocks and regolith. Previous attempts to detect organic molecules of biological or abiotic origin on Mars have been unsuccessful, whi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cecfe9740f2ed865e06c1ebbe5535a54
http://dspace.lib.cranfield.ac.uk/handle/1826/6888

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