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Akademický článek

Shifting the paradigm in personalized cancer care through next‐generation therapeutics and computational pathology

Autor: Jorge S. Reis‐Filho, Maurizio Scaltriti, Ansh Kapil, Hadassah Sade, Susan Galbraith

Publikováno v: Molecular Oncology, Vol 18, Iss 11, Pp 2607-2611 (2024)

The incorporation of novel therapeutic agents such as antibody‐drug conjugates, radio‐conjugates, T‐cell engagers, and chimeric antigen receptor cell therapies represents a paradigm shift in oncology. Cell‐surface target quantification, quant

Externí odkaz: https://doaj.org/article/9d347ab686e440cd84951119568cca8f

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Akademický článek

DETER-RT: The new INPE-TropiSCO deforestation monitoring system in the Amazon biome

Autor: J. Doblas, M. S. Reis, S. Mermoz, C. A. Almeida, T. Koleck, C. G. Messias, L. Soler, A. Bouvet, S. J. S. Sant’Anna

Publikováno v: The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences, Vol XLVIII-3-2024, Pp 127-133 (2024)

The Amazon biome, undergoing significant deforestation, requires robust monitoring systems for effective management and conservation. This study introduces DETER-RT, a novel deforestation detection system that combines the Synthetic Aperture Radar (S

Externí odkaz: https://doaj.org/article/1983ec1debd24f5b90f464dd61b491da

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Akademický článek

Two decades of fires in the Brazilian Amazon and the differences in patterns between open and forest vegetation

Autor: C. G. Messias, M. S. Reis, V. L. Camilotti, L. Soler, S. Amaral, D. L. Correia-Lima, L. V. Gatti, M. Adami, H. Xaud, M. Xaud, J. F. S. K. C. Pinto, G. E. T. Oliveira, L. H. Gusmão, G. S. Pinto, N. A. P. Moreira, L. P. Perez, M. R. R. Neto, L. E. P. Maurano, C. A. Almeida

Publikováno v: The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences, Vol XLVIII-3-2024, Pp 345-350 (2024)

This study investigated the pattern distribution of fires in the Brazilian Amazon and their relationship with deforested areas from 2003 to 2022. The primary objective was to analyze fire spots’ spatial and temporal variation. First, we examine whe

Externí odkaz: https://doaj.org/article/64fdb2ff94024b55b013887121335442

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Akademický článek

Prediction of homologous recombination deficiency from routine histology with attention-based multiple instance learning in nine different tumor types

Autor: Chiara Maria Lavinia Loeffler, Omar S. M. El Nahhas, Hannah Sophie Muti, Zunamys I. Carrero, Tobias Seibel, Marko van Treeck, Didem Cifci, Marco Gustav, Kevin Bretz, Nadine T. Gaisa, Kjong-Van Lehmann, Alexandra Leary, Pier Selenica, Jorge S. Reis-Filho, Nadina Ortiz-Bruechle, Jakob Nikolas Kather

Publikováno v: BMC Biology, Vol 22, Iss 1, Pp 1-14 (2024)

Abstract Background Homologous recombination deficiency (HRD) is recognized as a pan-cancer predictive biomarker that potentially indicates who could benefit from treatment with PARP inhibitors (PARPi). Despite its clinical significance, HRD testing

Externí odkaz: https://doaj.org/article/003303862b20434e84941368c6c014a7

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Akademický článek

RAD52 resolves transcription-replication conflicts to mitigate R-loop induced genome instability

Autor: Manisha Jalan, Aman Sharma, Xin Pei, Nils Weinhold, Erika S. Buechelmaier, Yingjie Zhu, Sana Ahmed-Seghir, Abhirami Ratnakumar, Melody Di Bona, Niamh McDermott, Joan Gomez-Aguilar, Kyrie S. Anderson, Charlotte K. Y. Ng, Pier Selenica, Samuel F. Bakhoum, Jorge S. Reis-Filho, Nadeem Riaz, Simon N. Powell

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)

Abstract Collisions of the transcription and replication machineries on the same DNA strand can pose a significant threat to genomic stability. These collisions occur in part due to the formation of RNA-DNA hybrids termed R-loops, in which a newly tr

Externí odkaz: https://doaj.org/article/7cd61270c6534754a1bbd7203bce046c

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Akademický článek

Large-scale copy number alterations are enriched for synthetic viability in BRCA1/BRCA2 tumors

Publikováno v: Genome Medicine, Vol 16, Iss 1, Pp 1-17 (2024)

Abstract Background Pathogenic BRCA1 or BRCA2 germline mutations contribute to hereditary breast, ovarian, prostate, and pancreatic cancer. Paradoxically, bi-allelic inactivation of BRCA1 or BRCA2 (bBRCA1/2) is embryonically lethal and decreases cell

Externí odkaz: https://doaj.org/article/a99e307f304a411b854e096a6e780f20

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Akademický článek

International survey on invasive lobular breast cancer identifies priority research questions

Publikováno v: npj Breast Cancer, Vol 10, Iss 1, Pp 1-7 (2024)

Abstract There is growing awareness of the unique etiology, biology, and clinical presentation of invasive lobular breast cancer (ILC), but additional research is needed to ensure translation of findings into management and treatment guidelines. We c

Externí odkaz: https://doaj.org/article/674206de519c4c9a91765a34839d5098

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Akademický článek

Comprehensive analysis of the electronic, thermodynamic, and spectroscopic properties of a Cu(II)-based complex with 1,10-phenanthroline and L-glutamine

Autor: Marinaldo V. Souza Junior, João G. Oliveira Neto, Walajhone O. Pereira, Jéssica A.O. Rodrigues, Jailton R. Viana, Aramys S. Reis, Mateus R. Lage, Guilherme G.C. Carvalho, Cláudia O. Pessoa, Adenilson O. dos Santos, Francisco F. de Sousa

Publikováno v: Heliyon, Vol 10, Iss 20, Pp e37505- (2024)

This study reports additional information's of geometric, electronic, thermodynamic, and vibrational properties of a Cu(II) complex with 1,10-phenanthroline and L-glutamine ligands. The experimental spectroscopic analyses were corroborated by density

Externí odkaz: https://doaj.org/article/d751564545c24adc800d5023c1e6815a

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