Zobrazeno 1 - 10
of 23
pro vyhledávání: '"A. S. Prahl"'
Publikováno v:
iScience, Vol 26, Iss 5, Pp 106657- (2023)
Summary: Tissue boundaries and interfaces are engines of morphogenesis in vivo. However, despite a wealth of micropatterning approaches available to control tissue size, shape, and mechanical environment in vitro, fine-scale spatial control of cell p
Externí odkaz:
https://doaj.org/article/7790458b519e4078b4f9bf23218a8c09
Replicating organizational principles that establish fine-scale tissue structure is critical to our capacity for building functional replacement tissues. Tissue boundaries such as epithelial-mesenchymal interfaces are engines for morphogenesisin vivo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ec971f0775ba613484087c448b16bbd
https://doi.org/10.1101/2022.11.16.516785
https://doi.org/10.1101/2022.11.16.516785
Autor:
John M. Viola, Jiageng Liu, Louis S. Prahl, Aria Huang, Trevor J. Chan, Gabriela Hayward-Lara, Catherine M. Porter, Chenjun Shi, Jitao Zhang, Alex J. Hughes
The kidney develops through elaboration of ureteric bud tubules (the future urinary collecting ducts), stroma, and nephron progenitors in the cap mesenchyme that surround each tubule tip as they branch. Dynamic interactions between these tissues coor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::afa7ecbf8bab777212b61ad75fb8b763
https://doi.org/10.1101/2022.06.03.494718
https://doi.org/10.1101/2022.06.03.494718
Publikováno v:
Developmental Cell. 58:110-120.e5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::532cfc4ea86d17ac76f32fcc7c796a38
https://doi.org/10.1016/j.devcel.2022.12.008
https://doi.org/10.1016/j.devcel.2022.12.008
The physiological functions of several organs rely on branched tubular networks, but little is known about conflicts in development between building enough tubules for adequate function and geometric constraints imposed by organ size. We show that th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::630bb0a209ab73a4cf9a5ab04d13f56c
https://doi.org/10.1101/2021.11.29.470441
https://doi.org/10.1101/2021.11.29.470441
Microtubule (MT) dynamic instability is a conserved phenomenon underlying essential cellular functions such as cell division, cell migration and intracellular transport, and is a key target of many chemotherapeutic agents. However, it remains unclear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28ed230da28132e3607e2cdd8819b092
https://doi.org/10.1101/2020.12.29.424770
https://doi.org/10.1101/2020.12.29.424770
Autor:
David J. Odde, Alexander R. Dunn, Sarah M. Anderson, Cayla M. Miller, Alice C. Chang, Louis S. Prahl, Steven Tan
Publikováno v:
Science Advances
Fluorescent molecular tension sensors reveal the dynamics of force transmission at cellular adhesion complexes.
Integrin-based adhesion complexes link the cytoskeleton to the extracellular matrix (ECM) and are central to the construction of mult
Integrin-based adhesion complexes link the cytoskeleton to the extracellular matrix (ECM) and are central to the construction of mult
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18a050fb2a94764d2a97a5e7a0049419
https://doi.org/10.1126/sciadv.aax0317
https://doi.org/10.1126/sciadv.aax0317
Publikováno v:
Biophysical Journal
Biophysical Journal, Biophysical Society, 2020, 118 (7), pp.1709-1720. ⟨10.1016/j.bpj.2020.01.048⟩
Biophysical Journal, Biophysical Society, 2020, 118 (7), pp.1709-1720. ⟨10.1016/j.bpj.2020.01.048⟩
International audience; Biological tissues contain micrometer-scale gaps and pores, including those found within extracellular matrix fiber networks, between tightly packed cells, and between blood vessels or nerve bundles and their associated baseme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e847672e7da2d54bef5bb4f4ec82856
https://hal.archives-ouvertes.fr/hal-03036509/document
https://hal.archives-ouvertes.fr/hal-03036509/document
Publikováno v:
Molecular Biology of the Cell
Chemotherapeutic agents that target microtubule dynamics promote a universal phenotype of kinetic stabilization. Integrated computational modeling and fluorescence microscopy identify the fundamental kinetic and thermodynamic mechanisms that result i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72cfb485bb2419aec6cd1c0b5921bbf8
https://doi.org/10.1091/mbc.e16-08-0567
https://doi.org/10.1091/mbc.e16-08-0567
Autor:
Matthew G. Rubashkin, Guanqing Ou, David J. Odde, Michael W. Davidson, Alexander R. Dunn, J. Matthew Barnes, Xin Ye, Jan Lammerding, Emily Bell, Alexandra L. McGregor, Louis S. Prahl, Christopher C. DuFort, Valerie M. Weaver, Steven Tan, Jonathan N. Lakins, Alice C. Chang, FuiBoon Kai, Armen H. Mekhdjian, Laralynne Przybyla, Luke Cassereau, Michael W. Pickup
Publikováno v:
Molecular Biology of the Cell
Molecular biology of the cell, vol 28, iss 11
Molecular biology of the cell, vol 28, iss 11
Mammary tumor cells adopt a basal-like phenotype when invading through a dense, stiffened, 3D matrix. These cells exert higher integrin-mediated traction forces, consistent with a physical motor-clutch model, display an altered molecular organization
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fa5ffb4115b47a9324a3c6bf9543f97
http://europepmc.org/articles/PMC5449147
http://europepmc.org/articles/PMC5449147