Zobrazeno 1 - 10
of 456
pro vyhledávání: '"A. S. Kondratov"'
Autor:
Stefan Gahbauer, Chelsea DeLeon, Joao M. Braz, Veronica Craik, Hye Jin Kang, Xiaobo Wan, Xi-Ping Huang, Christian B. Billesbølle, Yongfeng Liu, Tao Che, Ishan Deshpande, Madison Jewell, Elissa A. Fink, Ivan S. Kondratov, Yurii S. Moroz, John J. Irwin, Allan I. Basbaum, Bryan L. Roth, Brian K. Shoichet
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract The lipid prostaglandin E2 (PGE2) mediates inflammatory pain by activating G protein-coupled receptors, including the prostaglandin E2 receptor 4 (EP4R). Nonsteroidal anti-inflammatory drugs (NSAIDs) reduce nociception by inhibiting prostagl
Externí odkaz:
https://doaj.org/article/5afef5b1703241589164379113e645d4
Publikováno v:
Журнал органічної та фармацевтичної хімії, Vol 19, Iss 1, Pp 3-9 (2021)
Aim. To develop a convenient synthetic approach for the preparation of multigram amounts of 4-(trifluoromethoxy)-piperidine and 4-(trifluoromethoxymethyl)piperidine – promising building blocks for medicinal chemistry. Results and discussion. 4-(
Externí odkaz:
https://doaj.org/article/b53720b462db4c03b6498ead4e11fa30
Autor:
I. O. Feskov, I. S. Kondratov, Yu. O. Kuchkovska, V. S. Naumchyk, O. V. Onopchenko, O. O. Grygorenko
Publikováno v:
Журнал органічної та фармацевтичної хімії, Vol 18, Iss 4(72), Pp 14-22 (2020)
Aim. To synthesize cis- and trans-isomers of 3-(4-hydroxyphenyl)cyclobutanecarboxylic acid and evaluate the biological activity of their derivatives against GPR-40. Results and discussion. Cis- and trans-isomers of 3-(4-hydroxyphenyl)cyclobutanecarbo
Externí odkaz:
https://doaj.org/article/22033b8d36344219921bc75ce5849581
Publikováno v:
Oftalʹmologiâ, Vol 17, Iss 3s, Pp 577-584 (2020)
Purpose: To assess the iridocrystalline complex status in patients with cataract, complicated by zonular weakness, before and after surgical treatment. Patients and Methods. The study enrolled 28 patients (29 eyes) with cataract, complicated by zonul
Externí odkaz:
https://doaj.org/article/e542c0dab4f54da8b1db9b296d100b63
Publikováno v:
Журнал органічної та фармацевтичної хімії, Vol 18, Iss 3, Pp 55-59 (2020)
Aim. To develop a convenient synthetic approach for the preparation of multigram amounts of 2,2-difluoro-γ-aminobutyric acid, which is pharmacologically promising analog of γ-aminobutyric acid (GABA). Results and discussion. α,α-Difluoro-γ-am
Externí odkaz:
https://doaj.org/article/c99ce1ac30ca4cbc8e0b2d677ec98425
Akademický článek
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Publikováno v:
ACS Medicinal Chemistry Letters. 13:992-996
Ukrainian companies occupy an important niche in the global drug discovery process; however, before the Russian invasion, the role of Ukraine was not obvious. The biggest Ukrainian fine chemical supplier, Enamine Ltd, had to stop operation for more t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4f2f0a75c950754318f14bed0fe40f8
https://doi.org/10.1021/acsmedchemlett.2c00211
https://doi.org/10.1021/acsmedchemlett.2c00211
Challenges for chemistry in Ukraine after the war: Ukrainian science requires rebuilding and support
Autor:
Ivan S. Kondratov, Yurii S. Moroz, Christoph Gorgulla, Oleksandr O. Grygorenko, Igor V. Komarov, Gerhard Wagner, Andrey A. Tolmachev
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(50)
The unprovoked Russian invasion has created considerable challenges for Ukrainian science. In this article, we discuss actions needed to support and rebuild Ukrainian science and educational systems. The proposed actions take into account past Ukrain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b80994c81bc5b3e9862f9de8034cd26
https://pubmed.ncbi.nlm.nih.gov/36472958
https://pubmed.ncbi.nlm.nih.gov/36472958
Autor:
Anton V. Chernykh, Danylo Aloshyn, Yuliya O. Kuchkovska, Constantin G. Daniliuc, Nataliya A. Tolmachova, Ivan S. Kondratov, Sergey Zozulya, Oleksandr O. Grygorenko, Günter Haufe
Publikováno v:
Organicbiomolecular chemistry. 20(47)
The synthesis of all enantiopure N-Boc-protected β-CF3- and β-C2F5-prolines and the stability of their model dipeptide derivatives towards proteolytic degradation are reported.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fd70fee7d1a18113081b1b0c15b2584
https://pubmed.ncbi.nlm.nih.gov/36107003
https://pubmed.ncbi.nlm.nih.gov/36107003
Autor:
Oleksandr V. Hryshchuk, Igor I. Gerus, Constantin G. Daniliuc, Oleg M. Michurin, Olha V. Mykhailenko, Volodymyr O. Kovtunenko, Oleksandr O. Grygorenko, Bohdan V. Vashchenko, Kostiantyn P. Melnykov, Anton A. Homon, Ivan S. Kondratov
Publikováno v:
European Journal of Organic Chemistry. 2021:6580-6590
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4a8e6a85291325d615ff01e99a9c2b3
https://doi.org/10.1002/ejoc.202100414
https://doi.org/10.1002/ejoc.202100414