Zobrazeno 1 - 10
of 232
pro vyhledávání: '"A. S. Harms"'
Autor:
A. M. Schonhoff, D. A. Figge, G. P. Williams, A. Jurkuvenaite, N. J. Gallups, G. M. Childers, J. M. Webster, D. G. Standaert, J. E. Goldman, A. S. Harms
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Dopaminergic cell loss due to the accumulation of α-syn is a core feature of the pathogenesis of Parkinson disease. Neuroinflammation specifically induced by α-synuclein has been shown to exacerbate neurodegeneration, yet the role of centr
Externí odkaz:
https://doaj.org/article/56e05103cfa346b0beeae02b46eedc2e
Autor:
Enquan Xu, Ravindra Boddu, Hisham A. Abdelmotilib, Arpine Sokratian, Kaela Kelly, Zhiyong Liu, Nicole Bryant, Sidhanth Chandra, Samantha M. Carlisle, Elliot J. Lefkowitz, Ashley S. Harms, Etty N. Benveniste, Talene A. Yacoubian, Laura A. Volpicelli-Daley, David G. Standaert, Andrew B. West
Publikováno v:
Molecular Neurodegeneration, Vol 17, Iss 1, Pp 1-19 (2022)
Abstract Background Leucine rich repeat kinase 2 (LRRK2) and SNCA are genetically linked to late-onset Parkinson’s disease (PD). Aggregated α-synuclein pathologically defines PD. Recent studies identified elevated LRRK2 expression in pro-inflammat
Externí odkaz:
https://doaj.org/article/650263aba80f4a2ebcfa23775edbadc2
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Microglia are phagocytosis-competent CNS cells comprising a spectrum of subtypes with beneficial and/or detrimental functions in acute and chronic neurodegenerative disorders. The heterogeneity of microglia suggests differences in phagocytic activity
Externí odkaz:
https://doaj.org/article/138fbf2b689f42f6a23e708ce316e543
Autor:
Samantha M. Carlisle, Hongwei Qin, R. Curtis Hendrickson, Jordana E. Muwanguzi, Elliot J. Lefkowitz, Richard E. Kennedy, Zhaoqi Yan, Talene A. Yacoubian, Etty N. Benveniste, Andrew B. West, Ashley S. Harms, David G. Standaert
Publikováno v:
npj Parkinson's Disease, Vol 7, Iss 1, Pp 1-10 (2021)
Abstract Increasing evidence supports the role of brain and systemic inflammation in the etiology of Parkinson disease (PD). We used gene expression profiling to examine the activation state of peripheral blood monocytes in 18 patients with early, un
Externí odkaz:
https://doaj.org/article/05be2d31917548968fb8f99ff6f9f339
Autor:
Mike Khan, Jerome S Harms, Yiping Liu, Jens Eickhoff, Jin Wen Tan, Tony Hu, Fengwei Cai, Erika Guimaraes, Sergio Costa Oliveira, Richard Dahl, Yong Cheng, Delia Gutman, Glen N Barber, Gary A Splitter, Judith A Smith
Publikováno v:
PLoS Pathogens, Vol 16, Iss 10, p e1009020 (2020)
Brucellosis, caused by a number of Brucella species, remains the most prevalent zoonotic disease worldwide. Brucella establish chronic infections within host macrophages despite triggering cytosolic innate immune sensors, including Stimulator of Inte
Externí odkaz:
https://doaj.org/article/d2b3bfb878264b17877fb7ed40ea6334
Autor:
Gregory P. Williams, Aubrey M. Schonhoff, Asta Jurkuvenaite, Aaron D. Thome, David G. Standaert, Ashley S. Harms
Publikováno v:
Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-14 (2018)
Abstract Background Parkinson’s disease (PD) is characterized by intracellular alpha-synuclein (α-syn) inclusions, progressive death of dopaminergic neurons in the substantia nigra pars compacta (SNpc), and activation of the innate and adaptive im
Externí odkaz:
https://doaj.org/article/272314d6c741462b81a2af6fd89ea48f
Autor:
Stijn H. J. Ketelaers, Lieke Dhondt, Nikki van Ham, Ansgar S. Harms, Harm J. Scholten, Grard A. P. Nieuwenhuijzen, Harm J. T. Rutten, Jacobus W. A. Burger, Johanne G. Bloemen, F. Jeroen Vogelaar
Publikováno v:
Colorectal Disease, 24(10), 1172-1183. Wiley
Colorectal Disease, 24(10), 1172-1183. Wiley-Blackwell
Colorectal Disease, 24(10), 1172-1183. Wiley-Blackwell
AIM: To reduce detrimental opioid-related side effects, minimising the postoperative opioid consumption is needed, especially in older patients. Continuous wound infusion (CWI) with local analgesics seems an effective opioid-sparing alternative. Howe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ab0e8d3a8bc05b831fc43e608c5438e
https://doi.org/10.1111/codi.16201
https://doi.org/10.1111/codi.16201
Autor:
Ashley S. Harms, Vedad Delic, Aaron D. Thome, Nicole Bryant, Zhiyong Liu, Sidhanth Chandra, Asta Jurkuvenaite, Andrew B. West
Publikováno v:
Acta Neuropathologica Communications, Vol 5, Iss 1, Pp 1-16 (2017)
Abstract Genetic variation in a major histocompatibility complex II (MHCII)-encoding gene (HLA-DR) increases risk for Parkinson disease (PD), and the accumulation of MHCII-expressing immune cells in the brain correlates with α-synuclein inclusions.
Externí odkaz:
https://doaj.org/article/b13fd0a3da044874bb754f06182b7bf2
Autor:
Venkata Garlapati, Michael Molitor, Thomas Michna, Gregory S. Harms, Stefanie Finger, Rebecca Jung, Jeremy Lagrange, Panagiotis Efentakis, Johannes Wild, Maike Knorr, Susanne Karbach, Sabine Wild, Ksenija Vujacic-Mirski, Thomas Münzel, Andreas Daiber, Moritz Brandt, Tommaso Gori, Hendrik Milting, Stefan Tenzer, Wolfram Ruf, Philip Wenzel
Publikováno v:
Journal of Clinical Investigation. 133
Despite major advances in acute interventions of myocardial infarction (MI), adverse cardiac remodeling and excess fibrosis post MI causing ischemic heart failure (IHF) remains a leading cause of death worldwide. Here we identify a pro-fibrotic coagu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7de0920bd1f84505b9454aae2ad14f22
https://doi.org/10.1172/jci156436
https://doi.org/10.1172/jci156436
Publikováno v:
Handbook of Clinical Neurology ISBN: 9780323855556
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2bb9c70a7aeb06c7d54d4334e70e120d
https://doi.org/10.1016/b978-0-323-85555-6.00011-4
https://doi.org/10.1016/b978-0-323-85555-6.00011-4
