Zobrazeno 1 - 10
of 2 100
pro vyhledávání: '"A. S. Fraser"'
Autor:
Benjamin Mappin-Kasirer, Olivier Del Corpo, Marc-Alexandre Gingras, Aaron Hass, Jimmy M. Hsu, Cecilia T. Costiniuk, Nicole Ezer, Richard S. Fraser, Todd C. Lee, Emily G. McDonald
Publikováno v:
BMC Infectious Diseases, Vol 24, Iss 1, Pp 1-9 (2024)
Abstract Background The performance and availability of invasive and non-invasive investigations for the diagnosis of Pneumocystis jirovecii pneumonia (PCP) vary across clinical settings. Estimating the pre-test probability of PCP is essential to the
Externí odkaz:
https://doaj.org/article/9c7dfc112bc14a5fb86f5439c4dbc4f3
Autor:
Jailson Brito Querido, Masaaki Sokabe, Irene Díaz-López, Yuliya Gordiyenko, Philipp Zuber, Yifei Du, Lucas Albacete-Albacete, V. Ramakrishnan, Christopher S. Fraser
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Translation is regulated mainly in the initiation step, and its dysregulation is implicated in many human diseases. Several proteins have been found to regulate translational initiation, including Pdcd4 (programmed cell death gene 4). Pdcd4
Externí odkaz:
https://doaj.org/article/599c99b1be914e8b96ee7acf7713d645
Publikováno v:
IUCrJ, Vol 11, Iss 4, Pp 494-501 (2024)
In the folded state, biomolecules exchange between multiple conformational states crucial for their function. However, most structural models derived from experiments and computational predictions only encode a single state. To represent biomolecules
Externí odkaz:
https://doaj.org/article/0b2b761acf384d09b28475fb4cdafe9d
Autor:
Jingyou Rao, Ruiqi Xin, Christian Macdonald, Matthew K. Howard, Gabriella O. Estevam, Sook Wah Yee, Mingsen Wang, James S. Fraser, Willow Coyote-Maestas, Harold Pimentel
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-22 (2024)
Abstract Deep mutational scanning (DMS) measures the effects of thousands of genetic variants in a protein simultaneously. The small sample size renders classical statistical methods ineffective. For example, p-values cannot be correctly calibrated w
Externí odkaz:
https://doaj.org/article/f2997b4bc0bd45f1b3bfee9e093dce6c
Autor:
Gabriella O Estevam, Edmond M Linossi, Christian B Macdonald, Carla A Espinoza, Jennifer M Michaud, Willow Coyote-Maestas, Eric A Collisson, Natalia Jura, James S Fraser
Publikováno v:
eLife, Vol 12 (2024)
MET is a receptor tyrosine kinase (RTK) responsible for initiating signaling pathways involved in development and wound repair. MET activation relies on ligand binding to the extracellular receptor, which prompts dimerization, intracellular phosphory
Externí odkaz:
https://doaj.org/article/b6001b942b874658867de1b8cb4e8907
Autor:
Stephanie A Wankowicz, Ashraya Ravikumar, Shivani Sharma, Blake Riley, Akshay Raju, Daniel W Hogan, Jessica Flowers, Henry van den Bedem, Daniel A Keedy, James S Fraser
Publikováno v:
eLife, Vol 12 (2024)
In their folded state, biomolecules exchange between multiple conformational states that are crucial for their function. Traditional structural biology methods, such as X-ray crystallography and cryogenic electron microscopy (cryo-EM), produce densit
Externí odkaz:
https://doaj.org/article/df7cabe4cceb4472bbdd8fd7453b61bf
Autor:
Bianca A Schuster, Sophie Sowden, Alicia J Rybicki, Dagmar S Fraser, Clare Press, Lydia Hickman, Peter Holland, Jennifer L Cook
Publikováno v:
PLoS Biology, Vol 22, Iss 6, p e3002652 (2024)
Difficulties in reasoning about others' mental states (i.e., mentalising/Theory of Mind) are highly prevalent among disorders featuring dopamine dysfunctions (e.g., Parkinson's disease) and significantly affect individuals' quality of life. However,
Externí odkaz:
https://doaj.org/article/ff7ee9e7888c4b69bbc558f0392121e8
Autor:
Roberto Efraín Díaz, Andrew K Ecker, Galen J Correy, Pooja Asthana, Iris D Young, Bryan Faust, Michael C Thompson, Ian B Seiple, Steven Van Dyken, Richard M Locksley, James S Fraser
Publikováno v:
eLife, Vol 12 (2024)
Chitin is an abundant biopolymer and pathogen-associated molecular pattern that stimulates a host innate immune response. Mammals express chitin-binding and chitin-degrading proteins to remove chitin from the body. One of these proteins, Acidic Mamma
Externí odkaz:
https://doaj.org/article/1d6ac3d5e2914957b1f145449e49bd88
Publikováno v:
ISPRS Annals of the Photogrammetry, Remote Sensing and Spatial Information Sciences, Vol X-1-W1-2023, Pp 279-286 (2023)
Several methods exist that can be used to perform initial alignment of Building information models (BIMs) to the real building for Mixed Reality (MR) applications, such as marker-based or markerless visual methods, but this alignment is susceptible t
Externí odkaz:
https://doaj.org/article/6c356809d6ac450e9c792f552a524822
Autor:
Eloise Radcliffe, Renée Servin, Natalie Cox, Stephen Lim, Qian Yue Tan, Clare Howard, Claire Sheikh, Paul Rutter, Sue Latter, Mark Lown, Lawrence Brad, Simon D. S. Fraser, Katherine Bradbury, Helen C. Roberts, Alejandra Recio Saucedo, Kinda Ibrahim
Publikováno v:
BMC Geriatrics, Vol 23, Iss 1, Pp 1-28 (2023)
Abstract Background A third of older people take five or more regular medications (polypharmacy). Conducting medication reviews in primary care is key to identify and reduce/ stop inappropriate medications (deprescribing). Recent recommendations for
Externí odkaz:
https://doaj.org/article/05c86e73c46247a59978eee88a823b85