Výsledky vyhledávání - "A. S. E. Ojugo"

Issues of Normal Tissue Toxicity in Patient and Animal Studies - Effect of Carbogen Breathing in Rats after 5-Fluorouracil Treatment

Autor: Franklyn A. Howe, F. Lofts, Paul Noordhuis, Dominick J.O. McIntyre, Godefridus J. Peters, Paul M.J. McSheehy, Grainne Nicholson, Natasha M. Price, Loreta M. Rodrigues, John R. Griffiths, A. S. E. Ojugo, Peter Wadsworth, Kees Smid, Marion Stubbs

Publikováno v: Acta Oncologica. 40:609-614

Non-invasive magnetic resonance spectroscopy (MRS) can be used in the clinic to monitor the pharmacokinetics of the chemotherapeutic drug 5-fluorouracil (5-FU) and the effects of modifiers. We report two studies of 5-FU toxicity in normal tissue--one

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c64f36162e670764c6bf243aab8b9c0
https://doi.org/10.1080/028418601750444150

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Measurement of the extracellular pH of solid tumours in mice by magnetic resonance spectroscopy: a comparison of exogenous19F and31P probes

Autor: A. S. E. Ojugo, Martin O. Leach, Ian Judson, John R. Griffiths, Paul M.J. McSheehy, Dominick J.O. McIntyre, C. L. McCoy, Marion Stubbs

Publikováno v: NMR in Biomedicine. 12:495-504

Precise measurement of pHein vivo may be of clinical value for both diagnosis and selection of therapy. pHe measurements made by the 31P probe 3-aminopropylphosphonate (3-APP) were compared with those made by the 19F probe, 3-[N-(4-fluor-2-trifluorom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::41cf80145bf429a1aabd300c9df30b55
https://doi.org/10.1002/(sici)1099-1492(199912)12:8<495::aid-nbm594>3.0.co

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A pharmacokinetic and pharmacodynamic study In vivo of human HT29 tumours using 19F and 31P magnetic resonance spectroscopy

Autor: A. S. E. Ojugo, Ian Judson, Matthew T. Seymour, Loreta M. Rodrigues, John R. Griffiths, Paul M.J. McSheehy, Martin O. Leach

Publikováno v: European Journal of Cancer. 33:2418-2427

19F-MRS (magnetic resonance spectroscopy) was used to study the pharmacokinetics of 5-fluorouracil (5-FU) in human (HT29) tumour xenografts, with and without pretreatment of the mice using either thymidine (40 min) or interferon-alpha (2 and 24 h). A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53d44fada047069fa6e5c732302e4a4c
https://doi.org/10.1016/s0959-8049(97)00336-5

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The response to carbogen breathing in experimental tumour models monitored by gradient-recalled echo magnetic resonance imaging

Autor: Simon P. Robinson, Paul M.J. McSheehy, Franklyn A. Howe, Loreta M. Rodrigues, John R. Griffiths, A. S. E. Ojugo

Publikováno v: British Journal of Cancer

Gradient-recalled echo magnetic resonance imaging (GRE MRI), which gives information on blood flow and oxygenation changes (Robinson SP, Howe FA, Griffiths JR 1995, Int J Radiat Oncol Biol Phys 33: 855), was used to observe the responses of six roden

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15c8fcb54e76fea759af5040897cf35f
https://doi.org/10.1038/bjc.1997.172

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