Zobrazeno 1 - 10
of 339
pro vyhledávání: '"A. S. Arseniev"'
Autor:
F. D. Kornilov, A. V. Shabalkina, Cong Lin, P. E. Volynsky, E. F. Kot, A. L. Kayushin, V. A. Lushpa, M. V. Goncharuk, A. S. Arseniev, S. A. Goncharuk, Xiaohui Wang, K. S. Mineev
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Toll-like receptors (TLRs) play a key role in the innate immune system. Here, Kornilov et al. resolve the 3D structures of the membrane-associated parts of four TLRs to reveal properties of the juxta-membrane domain.
Externí odkaz:
https://doaj.org/article/baf24e9ec2e8437598a63374214adbcb
Autor:
Marina V. Goncharuk, Nadezhda S. Baleeva, Dmitry E. Nolde, Alexey S. Gavrikov, Alexey V. Mishin, Alexander S. Mishin, Andrey Y. Sosorev, Alexander S. Arseniev, Sergey A. Goncharuk, Valentin I. Borshchevskiy, Roman G. Efremov, Konstantin S. Mineev, Mikhail S. Baranov
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-10 (2022)
Structural analyses guide the rational design of mutant fluorogen-activating proteins with enhanced fluorescence.
Externí odkaz:
https://doaj.org/article/9f5e4001803e45c99f3b5822fd1097f3
Autor:
Ekaterina N. Grafskaia, Elizaveta R. Pavlova, Ivan A. Latsis, Maja V. Malakhova, Dmitrii V. Ivchenkov, Pavel V. Bashkirov, Erik F. Kot, Konstantin S. Mineev, Alexander S. Arseniev, Dmitry V. Klinov, Vassili N. Lazarev
Publikováno v:
Materials & Design, Vol 224, Iss , Pp 111364- (2022)
The number of infections caused by antibiotic-resistant pathogens is increasing alarmingly every year and will continue to grow. Antimicrobial peptides (AMPs) are considered new therapeutic agents for the effective combat against infectious diseases.
Externí odkaz:
https://doaj.org/article/173efa149e7440e38205a7555417109a
Autor:
Vladislav A. Lushpa, Marina V. Goncharuk, Cong Lin, Arthur O. Zalevsky, Irina A. Talyzina, Aleksandra P. Luginina, Daniil D. Vakhrameev, Mikhail B. Shevtsov, Sergey A. Goncharuk, Alexander S. Arseniev, Valentin I. Borshchevskiy, Xiaohui Wang, Konstantin S. Mineev
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Lushpa et al report the structure and dynamics of the TLR1 toll-interleukin like (TIR) cytoplasmic domain in both crystal and solution. They demonstrate that the TLR1 TIR domain is capable of specific binding of Zn with nanomolar affinity, which appe
Externí odkaz:
https://doaj.org/article/ba1903b9028f4b788d2c7b76bc761832
Autor:
Alexey I. Kuzmenkov, Steve Peigneur, Joshua A. Nasburg, Konstantin S. Mineev, Maxim V. Nikolaev, Ernesto Lopes Pinheiro-Junior, Alexander S. Arseniev, Heike Wulff, Jan Tytgat, Alexander A. Vassilevski
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Apamin is often cited as one of the few substances selectively acting on small-conductance Ca2+-activated potassium channels (KCa2). However, published pharmacological and structural data remain controversial. Here, we investigated the molecular phar
Externí odkaz:
https://doaj.org/article/03250e942dc5484ca71aad07a5e99041
Autor:
Erik F. Kot, María L. Franco, Ekaterina V. Vasilieva, Alexandra V. Shabalkina, Alexander S. Arseniev, Sergey A. Goncharuk, Konstantin S. Mineev, Marçal Vilar
Publikováno v:
iScience, Vol 25, Iss 6, Pp 104348- (2022)
Summary: Receptor tyrosine kinases (RTKs) are key players in development and several diseases. Understanding the molecular mechanism of RTK activation by its ligand could lead to the design of new RTK inhibitors. How the extracellular domain is coupl
Externí odkaz:
https://doaj.org/article/9b52a2d299164968b90fdd885a5b98ad
Autor:
Sergey A. Goncharuk, Lilya E. Artemieva, Kirill D. Nadezhdin, Alexander S. Arseniev, Konstantin S. Mineev
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Abstract The neurotrophin receptor p75NTR plays crucial roles in neuron development and regulates important neuronal processes like degeneration, apoptosis and cell survival. At the same time the detailed mechanism of signal transduction is unclear.
Externí odkaz:
https://doaj.org/article/93e81a0ed52f4a949f2c31ba9f7ec4c9
Autor:
Vladislav V. Motov, Erik F. Kot, Alexandra V. Shabalkina, Sergey A. Goncharuk, Alexander S. Arseniev, Marina V. Goncharuk, Konstantin S. Mineev
Publikováno v:
Journal of Biomolecular NMR. 77:15-24
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad984f051d006e3fde4a4733a78c8629
https://doi.org/10.1007/s10858-022-00408-x
https://doi.org/10.1007/s10858-022-00408-x
Autor:
Sergey L. Deev, Alexander S. Paramonov, Tatyana S. Shestakova, Igor A. Khalymbadzha, Oleg N. Chupakhin, Julia O. Subbotina, Oleg S. Eltsov, Pavel A. Slepukhin, Vladimir L. Rusinov, Alexander S. Arseniev, Zakhar O. Shenkarev
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 13, Iss 1, Pp 2535-2548 (2017)
Determining the accurate chemical structures of synthesized compounds is essential for biomedical studies and computer-assisted drug design. The unequivocal determination of N-adamantylation or N-arylation site(s) in nitrogen-rich heterocycles, chara
Externí odkaz:
https://doaj.org/article/521f1f61d3474495a26c7f41618b4e52
Autor:
Mikhail Yu. Myshkin, Roope Männikkö, Olesya A. Krumkacheva, Dmitrii S. Kulbatskii, Anton O. Chugunov, Antonina A. Berkut, Alexander S. Paramonov, Mikhail A. Shulepko, Matvey V. Fedin, Michael G. Hanna, Dimitri M. Kullmann, Elena G. Bagryanskaya, Alexander S. Arseniev, Mikhail P. Kirpichnikov, Ekaterina N. Lyukmanova, Alexander A. Vassilevski, Zakhar O. Shenkarev
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Voltage-gated sodium (NaV) channels are essential for the normal functioning of cardiovascular, muscular, and nervous systems. These channels have modular organization; the central pore domain allows current flow and provides ion selectivity, whereas
Externí odkaz:
https://doaj.org/article/4464bf84a7ef4033a00db58a1fd06aed