Zobrazeno 1 - 10
of 111
pro vyhledávání: '"A. S. Abutaleb"'
Autor:
Hanan Almolhim, Ahmed E. M. Elhassanny, Nader S. Abutaleb, Abdallah S. Abdelsattar, Mohamed N. Seleem, Paul R. Carlier
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Drug-resistant Neisseria gonorrhoeae represents a major threat to public health; without new effective antibiotics, untreatable gonococcal infections loom as a real possibility. In a previous drug-repurposing study, we reported that salicyli
Externí odkaz:
https://doaj.org/article/c26694101c4048b0850c76616094ccb5
Autor:
Simone Giovannuzzi, Anil Kumar Marapaka, Nader S. Abutaleb, Fabrizio Carta, Hsin-Wen Liang, Alessio Nocentini, Luigi Pisano, Mohamed N. Seleem, Daniel P. Flaherty, Claudiu T. Supuran
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
Carbonic anhydrases (CAs) from the pathogenic bacteria Nesseria gonorrhoeae and vancomycin-resistant enterococci (VRE) have recently been validated as antibacterial drug targets. Here we explored the inhibition of the α-CA from N. gonorrhoeae (α-Ng
Externí odkaz:
https://doaj.org/article/c4d2014469974e81944e86da38a9887d
Autor:
Weiwei An, Katrina J. Holly, Alessio Nocentini, Ryan D. Imhoff, Chad. S. Hewitt, Nader S. Abutaleb, Xufeng Cao, Mohamed N. Seleem, Claudiu T. Supuran, Daniel P. Flaherty
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 1838-1844 (2022)
Vancomycin-resistant enterococci (VRE), consisting of pathogenic Enterococcus faecalis and E. faecium, is a leading cause of hospital-acquired infections (HAIs). We recently repurposed the FDA-approved human carbonic anhydrase (CA) inhibitor acetazol
Externí odkaz:
https://doaj.org/article/289046e46d9a42fe9840d656ae4ed36e
Autor:
Simone Giovannuzzi, Nader S. Abutaleb, Chad S. Hewitt, Fabrizio Carta, Alessio Nocentini, Mohamed N. Seleem, Daniel P. Flaherty, Claudiu T. Supuran
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 1-8 (2022)
Recently, inorganic anions and sulphonamides, two of the main classes of zinc-binding carbonic anhydrase inhibitors (CAIs), were investigated for inhibition of the α-class carbonic anhydrase (CA, EC 4.2.1.1) from Neisseria gonorrhoeae, NgCA. As an e
Externí odkaz:
https://doaj.org/article/8103ce235a6247a5897dbdaf78bc3e41
Autor:
Nader S. Abutaleb, Ahmed E. M. Elhassanny, Alessio Nocentini, Chad S. Hewitt, Ahmed Elkashif, Bruce R. Cooper, Claudiu T. Supuran, Mohamed N. Seleem, Daniel P. Flaherty
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 51-61 (2022)
Neisseria gonorrhoeae is a high-priority pathogen of concern due to the growing prevalence of resistance development against approved antibiotics. Herein, we report the anti-gonococcal activity of ethoxzolamide, the FDA-approved human carbonic anhydr
Externí odkaz:
https://doaj.org/article/908f9289255d400d818e259d8b402431
Autor:
Haroon Mohammad, Nader S. Abutaleb, Alexandra M. Dieterly, L. Tiffany Lyle, Mohamed N. Seleem
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Bacterial infection of pressure ulcers (PUs) are a notable source of hospitalization for individuals with diabetes. This study evaluated the safety profile and efficacy of auranofin to treat diabetic PUs infected with methicillin-resistant S
Externí odkaz:
https://doaj.org/article/0d5e66fa42a74201b1071507c9212963
Autor:
Nader S. Abutaleb, Mohamed N. Seleem
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
Abstract Clostridioides difficile infections (CDIs) are an urgent public health threat worldwide and are a leading cause of morbidity and mortality in healthcare settings. The increasing incidence and severity of infections combined with the scarcity
Externí odkaz:
https://doaj.org/article/0da84e67d61c438098f83388cd104305
Publikováno v:
PLoS ONE, Vol 17, Iss 4, p e0266764 (2022)
Neisseria gonorrhoeae has been classified by the U.S. Centers for Disease Control and Prevention as an urgent threat due to the rapid development of antibiotic resistance to currently available antibiotics. Therefore, there is an urgent need to find
Externí odkaz:
https://doaj.org/article/2c310237b2cd465597b3e2b9f7651098
Autor:
Caroline W. Karanja, Nimishetti Naganna, Nader S. Abutaleb, Neetu Dayal, Kenneth I. Onyedibe, Uma Aryal, Mohamed N. Seleem, Herman O. Sintim
Publikováno v:
Molecules, Vol 27, Iss 16, p 5085 (2022)
A new class of alkynyl isoquinoline antibacterial compounds, synthesized via Sonogashira coupling, with strong bactericidal activity against a plethora of Gram-positive bacteria including methicillin- and vancomycin-resistant Staphylococcus aureus (S
Externí odkaz:
https://doaj.org/article/c6e05fb522464e4eb21a3521ac1bfb0e
Autor:
Nader S. Abutaleb, Annadka Shrinidhi, Aloka B. Bandara, Mohamed N. Seleem, Daniel P. Flaherty
Publikováno v:
ACS Medicinal Chemistry Letters. 14:487-492