In vivo evaluation of tropism and biodistribution of synthetic and natural adeno-associated viral vectors by next-generation sequencing

Autor: D. O. Maksimov, D. A. Naumova, E. A. Astakhova, V. V. Artemev, S. A. Biryukov, I. S. Abramov, A. A. Navoikova, N. V. Rudev, S. G. Feoktistova, O. V. Glazova, O. N. Mityaeva, P. Yu. Volchkov

Publikováno v: Биопрепараты: Профилактика, диагностика, лечение, Vol 24, Iss 2, Pp 215-228 (2024)

INTRODUCTION. The creation of synthetic adeno-associated virus (AAV) vectors during gene therapy development is a labour-intensive and expensive process. The optimal solution to minimise the time and costs associated with gene therapy development lie

Externí odkaz: https://doaj.org/article/ca88668e6b554917a47143e75b0e751a

Codon-optimization in gene therapy: promises, prospects and challenges

Autor: Anastasiia Iu Paremskaia, Anna A. Kogan, Anastasiia Murashkina, Daria A. Naumova, Anakha Satish, Ivan S. Abramov, Sofya G. Feoktistova, Olga N. Mityaeva, Andrei A. Deviatkin, Pavel Yu Volchkov

Publikováno v: Frontiers in Bioengineering and Biotechnology, Vol 12 (2024)

Codon optimization has evolved to enhance protein expression efficiency by exploiting the genetic code’s redundancy, allowing for multiple codon options for a single amino acid. Initially observed in E. coli, optimal codon usage correlates with hig

Externí odkaz: https://doaj.org/article/9699a43d03b240e58c0b8fc9c740ce99

Hereditary diffuse gastric cancer associated with a novel germline variant c.1596G>A in the CDH1 gene

Autor: A. M. Danishevich, T. S. Lisitsa, S. E. Nikolaev, I. S. Abramov, M. G. Filippova, N. I. Pospekhova, A. M. Stroganova, M. P. Nikulin, A. E. Kalinin, I. S. Stilidi, L. N. Lyubchenko

Publikováno v: Успехи молекулярной онкологии, Vol 10, Iss 1, Pp 87-93 (2023)

Gastric cancer is one of the most common malignancies worldwide. Approximately 10 % of patients with gastric cancer are characterized by accumulation of gastric cancer cases in their family. The hereditary forms of gastric cancer account for 1–3 %

Externí odkaz: https://doaj.org/article/98967059ec0e4837b4dfad887171168f

Enhanced plasma performance in C-2W advanced beam-driven field-reversed configuration experiments

Autor: H. Gota, A. Smirnov, M.W. Binderbauer, T. Tajima, S. Putvinski, J.B. Titus, M. Nations, T. Roche, E. Trask, T. DeHaas, S.A. Dettrick, E.M. Granstedt, D.K. Gupta, S. Gupta, A.A. Ivanov, S. Korepanov, R.M. Magee, T. Matsumoto, J.A. Romero, P. Yushmanov, K. Zhai, L. Schmitz, Z. Lin, S. Krasheninnikov, E.A. Baltz, J.C. Platt, E.V. Belova, T. Asai, A.I. Smolyakov, S. Abdollahi, S. Abramov, A. Alexander, I. Allfrey, R. Andow, D.C. Barnes, B. Barnett, J. Barrett, M. Beall, N.G. Bolte, E. Bomgardner, A. Bondarenko, F. Brighenti, J. Buttery, S. Caton, F. Ceccherini, Y. Choi, R. Clary, A. Cooper, C. Deng, A. de Vera, J. Drobny, A. Dunaevsky, C. Exton, A. Fareed, P. Feng, C. Finucane, D. Fluegge, A. Fontanilla, Y. Fujiwara, L. Galeotti, S. Galkin, R. Groenewald, T. Hsyu, K. Hubbard, R. Jaber, L. Jian, N. Kafle, S. Kamio, S. Karbashewski, J.S. Kinley, A. Korepanov, G. Koumarianou, S. Krause, P. Kudrin, C.K. Lau, H. Leinweber, J. Leuenberger, D. Lieurance, M. Litton, R. Luna, R. Luong, J. MacFarlane, D. Madura, J. Margo, D. Marshall, V. Matvienko, M. Meekins, W. Melian, R. Mendoza, R. Michel, M. Morehouse, Y. Musthafa, S. Nazarenko, A. Necas, B.S. Nicks, N. Nwoke, S. Ohshima, M. Onofri, R. Page, J. Park, E. Parke, S. Patel, L. Pennings, K. Phung, G. Player, L. Rios, I. Sato, J.H. Schroeder, Y. Shimabukuro, M. Showers, A. Sibley, M. Signorelli, M. Slepchenkov, R.J. Smith, G. Snitchler, V. Sokolov, D. Solyakov, Y. Song, B. Sporer, L.C. Steinhauer, C. Stonier, A. Stratta, J. Sweeney, M. Tobin, M. Tuszewski, J. Ufnal, T. Valentine, S. Vargas, A.D. Van Drie, V. Vekselman, A. Veksler, C. Weixel, C. White, M. Wollenberg, J. Wood, Y. Zhou, S. Ziaei, the TAE Team

Publikováno v: Nuclear Fusion, Vol 64, Iss 11, p 112014 (2024)

TAE Technologies’ fifth-generation fusion device, C-2W (also called ‘Norman’), is the world’s largest compact-toroid device and has made significant progress in field-reversed configuration (FRC) plasma performance. C-2W produces record break

Externí odkaz: https://doaj.org/article/256b81cac41043c1a97676b160e67300

Genomic epidemiology of SARS-CoV-2 in Russia reveals recurring cross-border transmission throughout 2020.

Autor: Alina Matsvay, Galya V Klink, Ksenia R Safina, Elena Nabieva, Sofya K Garushyants, Dmitry Biba, Georgii A Bazykin, Ivan M Mikhaylov, Anna V Say, Anastasiya I Zakamornaya, Anastasiya O Khakhina, Tatiana S Lisitsa, Andrey A Ayginin, Ivan S Abramov, Sergey A Bogdan, Kseniya B Kolbutova, Daria U Oleynikova, Tatiana F Avdeenko, German A Shipulin, Sergey M Yudin, Veronika I Skvortsova

Publikováno v: PLoS ONE, Vol 18, Iss 5, p e0285664 (2023)

In 2020, SARS-CoV-2 has spread rapidly across the globe, with most nations failing to prevent or substantially delay its introduction. While many countries have imposed some limitations on trans-border passenger traffic, the effect of these measures

Externí odkaz: https://doaj.org/article/0c1e4b31d7af40d983f3a24a0f4a9a5d