Circadian clock mechanism driving mammalian photoperiodism

Autor: S. H. Wood, M. M. Hindle, Y. Mizoro, Y. Cheng, B. R. C. Saer, K. Miedzinska, H. C. Christian, N. Begley, J. McNeilly, A. S. McNeilly, S. L. Meddle, D. W. Burt, A. S. I. Loudon

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)

“Life in a seasonal environment requires appropriate timing of physiological changes to survive, but how the circadian clockwork times these changes remains unclear. Here the authors show that the circadian clock genes BMAL2 and DEC1, in concert wi

Externí odkaz: https://doaj.org/article/7fb5add7468b4e49b866c4366595cefd

Quantitative live imaging of Venus::BMAL1 in a mouse model reveals complex dynamics of the master circadian clock regulator.

Autor: Nan Yang, Nicola J Smyllie, Honor Morris, Cátia F Gonçalves, Michal Dudek, Dharshika R J Pathiranage, Johanna E Chesham, Antony Adamson, David G Spiller, Egor Zindy, James Bagnall, Neil Humphreys, Judith Hoyland, Andrew S I Loudon, Michael H Hastings, Qing-Jun Meng

Publikováno v: PLoS Genetics, Vol 16, Iss 4, p e1008729 (2020)

Evolutionarily conserved circadian clocks generate 24-hour rhythms in physiology and behaviour that adapt organisms to their daily and seasonal environments. In mammals, the suprachiasmatic nucleus (SCN) of the hypothalamus is the principal co-ordina

Externí odkaz: https://doaj.org/article/43fa25b09c644bd38b2e46c67b3637c5

Effects of Spring Warming on Seasonal Neuroendocrinology and Activation of the Reproductive Axis in Hibernating Arctic Ground Squirrels

Autor: Helen E Chmura, Cassandra Duncan, Ben Saer, Jeanette T Moore, Brian M Barnes, C Loren Buck, Andrew S I Loudon, Cory T Williams

Publikováno v: Integr Comp Biol

Many animals adjust the timing of seasonal events, such as reproduction, molt, migration, and hibernation, in response to interannual variation and directional climate-driven changes in temperature. However, the mechanisms by which temperature influe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7e07641384fb74f42d8413866603e22
https://doi.org/10.1093/icb/icac112

Chronic inflammatory arthritis drives systemic changes in circadian energy metabolism

Autor: Polly Downton, Fabio Sanna, Robert Maidstone, Toryn M. Poolman, Edward A. Hayter, Suzanna H. Dickson, Nick A. Ciccone, James O. Early, Antony Adamson, David G. Spiller, Devin A. Simpkins, Matthew Baxter, Roman Fischer, Magnus Rattray, Andrew S. I. Loudon, Julie E. Gibbs, David A. Bechtold, David W. Ray

Publikováno v: Downton, P, Sanna, F, Maidstone, R, Poolman, T, Hayter, E, Dickson, S, Early, J, Adamson, A, Spiller, D, Simpkins, D, Baxter, M, Fischer, R, Rattray, M, Loudon, A, Gibbs, J, Bechtold, D & Ray, D 2022, ' Chronic inflammatory arthritis drives systemic changes in circadian energy metabolism ', PNAS . https://doi.org/10.1073/pnas.2112781119

Chronic inflammation underpins many human diseases. Morbidity and mortality associated with chronic inflammation are often mediated through metabolic dysfunction. Inflammatory and metabolic processes vary through circadian time, suggesting an importa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::017529c2364b29af243534f1e7291915
https://research.manchester.ac.uk/en/publications/800a87b1-8e94-4db1-bc84-0c5accdfbaf1

Seasonal changes in NRF2 antioxidant pathway regulates winter depression-like behavior

Autor: Ayato Sato, Jiachen Shen, Andrew S. I. Loudon, Naoyuki Yamamoto, Akiko Shimada, Toshiya Nishimura, Toshitaka Nabeshima, Naoya Kadofusa, Kei Nakayama, Souta Minou, Minoru Tanaka, Nobuyuki Shiina, Tomoya Nakayama, Ai Shinomiya, Takashi Yoshimura, Ying-Jey Guh, Yuki Okushi, Taeko Nishiwaki-Ohkawa, Yusuke Nakane, Tsuyoshi Shimmura, T. Katherine Tamai, Yuko Furukawa, Kousuke Okimura

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America

Significance At high latitudes, about 10% of the population suffers from depression in winter. Although it has become a serious public health issue, its underlying mechanism remains unknown. Interestingly, animals also show depression-like behavior i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c65153757bd73a2dc4a52ef20d08ffba
https://doi.org/10.1073/pnas.2000278117