Zobrazeno 1 - 10
of 408
pro vyhledávání: '"A. Ruiz i Altaba"'
Publikováno v:
In Cell Reports 8 March 2022 38(10)
Autor:
Bernal, Carolina, Silvano, Marianna, Tapponnier, Yann, Anand, Santosh, Angulo, Cecilia, Ruiz i Altaba, Ariel
Publikováno v:
In Cell Reports 10 November 2020 33(6)
Publikováno v:
Cell Reports, Vol 38, Iss 10, Pp 110490- (2022)
Summary: How metastatic cells arise is unclear. Here, we search for the induction of recently characterized pro-metastatic states as a surrogate for the origin of metastasis. Since cell-death-inducing therapies can paradoxically promote metastasis, w
Externí odkaz:
https://doaj.org/article/90c3409d083544adbe4f0dd4d75ddd5e
Autor:
Aberger, Fritz, Ruiz i Altaba, Ariel
Publikováno v:
In Seminars in Cell and Developmental Biology September 2014 33:93-104
Autor:
Alice Melotti, Christophe Mas, Monika Kuciak, Aiala Lorente‐Trigos, Isabel Borges, Ariel Ruiz i Altaba
Publikováno v:
EMBO Molecular Medicine, Vol 6, Iss 10, Pp 1263-1278 (2014)
Abstract Constitutive activation of canonical WNT‐TCF signaling is implicated in multiple diseases, including intestine and lung cancers, but there are no WNT‐TCF antagonists in clinical use. We have performed a repositioning screen for WNT‐TCF
Externí odkaz:
https://doaj.org/article/0847a9c96622445d943063c107ec027f
Autor:
Arnaud Duquet, Alice Melotti, Sonakshi Mishra, Monica Malerba, Chandan Seth, Arwen Conod, Ariel Ruiz i Altaba
Publikováno v:
EMBO Molecular Medicine, Vol 6, Iss 7, Pp 882-901 (2014)
Abstract The progression of tumors to the metastatic state involves the loss of metastatic suppressor functions. Finding these, however, is difficult as in vitro assays do not fully predict metastatic behavior, and the majority of studies have used c
Externí odkaz:
https://doaj.org/article/9335cc5f8719458cbd007765a16efc97
Autor:
Verbeni, M., Sánchez, O., Mollica, E., Siegl-Cachedenier, I., Carleton, A., Guerrero, I., Ruiz i Altaba, A., Soler, J.
Publikováno v:
In Physics of Life Reviews December 2013 10(4):457-475
Autor:
Chandan Seth, Ariel Ruiz I Altaba
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0160904 (2016)
[This corrects the article DOI: 10.1371/journal.pone.0150697.].
Externí odkaz:
https://doaj.org/article/04a1403183e745fab5250f93a8227295
Autor:
Chandan Seth, Christophe Mas, Arwen Conod, Jens Mueller, Karsten Siems, Monika Kuciak, Isabel Borges, Ariel Ruiz I Altaba
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0168170 (2016)
The WNT-TCF signaling pathway participates in adult tissue homeostasis and repair, and is hyperactive in a number of human diseases including cancers of the colon. Whereas to date there are no antagonists approved for patient use, a potential problem
Externí odkaz:
https://doaj.org/article/6c75967e282544b9b63179d43644bc9c
Autor:
Chandan Seth, Ariel Ruiz i Altaba
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0150697 (2016)
Human colon cancers commonly harbor loss of function mutations in APC, a repressor of the canonical WNT pathway, thus leading to hyperactive WNT-TCF signaling. Re-establishment of Apc function in mice, engineered to conditionally repress Apc through
Externí odkaz:
https://doaj.org/article/28bb81c5faba4b90b3bb9d4fb82100d4