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LINE-1 transcription in round spermatids is associated with accretion of 5-carboxylcytosine in their open reading frames

Autor: Blythe, Martin J., Kocer, Ayhan, Rubio-Roldan, Alejandro, Giles, Tom, Abakir, Abdulkadir, Wheldon, Lee M., Bereshchenko, Oxana, Bruscoli, Stefano, Kondrashov, Alexander, Emes, Richard D., Johnson, Andrew D., McCarrey, John R., Gackowski, Daniel, Olinski, Ryszard, Cocquet, Julie, Garcia-Perez, Jose L., Ruzov, Alexey

Chromatin of male and female gametes undergoes a number of reprogramming events during the transition from germ cell to embryonic developmental programs. Although the rearrangement of DNA methylation patterns occurring in the zygote has been extensiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::5f02099a73c50bb084a5ac4fdd218e24

cGAS-mediated induction of type I interferon due to inborn errors of histone pre-mRNA processing

Autor: Jennifer Doig, Hélio van der Linden, Ram Kumar, Waad Albawardi, Mathieu P Rodero, Caroline A Salmon, Angus Dobbie, Hilde Van Esch, Marie Vermelle, Cristina Cereda, Nick Gilbert, Marine Depp, Andrew P. Jackson, Kevin Rostasy, Robert Olaso, Jean-François Deleuze, Luis Seabra, Frances Elmslie, Davide Tonduti, Diane Doummar, Somdutta Dhir, Duncan Sproul, Alice Lepelley, John H. Livingston, Kate Webb, Yanick J. Crow, Alejandro Rubio-Roldan, Marie-Louise Frémond, Christiaan Scott, Simona Orcesi, Ashish Dhir, Sylviane Peudenier, Guy Touati, Anirban Majumdar, Kate Lamb, Jose L. Garcia-Perez, Vanessa Cavallera, Liesbeth De Waele, Maria José Martin-Niclos, Julien Baruteau, Marie-Thérèse El-Daher, Jonny Hertzog, Jonathan Buckley, Martin A M Reijns, Charles Marques Lorenço, Erika Della Mina, Marialuisa Valente, Karine Brochard, Anne Boland-Auge, Andrew P. Badrock, Ann P. Wheeler, Natalie F. Blair, Carolina Uggenti, Gillian I. Rice, Margarete Koch-Hogrebe, Jan Rehwinkel

Publikováno v: Uggenti, C, Lepelley, A, Depp, M, Badrock, A P, Rodero, M P, El-Daher, M-T, Rice, G I, Dhir, S, Wheeler, A P, Dhir, A, Albawardi, W, Fremond, M-L, Seabra, L, Doig, J, Blair, N, Martin-Niclos, M J, Della Mina, E, Rubio-Roldan, A, Garcia-Perez, J L, Sproul, D, Rehwinkel, J, Hertzog, J, Boland-Auge, A, Olaso, R, Deleuze, J-F, Baruteau, J, Brochard, K, Buckley, J, Cavallera, V, Cereda, C, De Waele, L M H, Dobbie, A, Doummar, D, Elmslie, F, Koch-Hogrebe, M, Kumar, R, Lamb, K, Livingston, J H, Majumdar, A, Lorenco, C M, Orcesi, S, Peudenier, S, Rostasy, K, Salmon, C A, Scott, C, Tonduti, D, Touati, G, Valente, M, van der Linden, H J, Van Esch, H, Vermelle, M, Webb, K, Jackson, A P, Reijns, M A M, Gilbert, N & Crow, Y J 2020, ' cGAS-mediated induction of type I interferon due to inborn errors of histone pre-mRNA processing ', Nature Genetics, vol. 52, no. 12, pp. 1364-1372 . https://doi.org/10.1038/s41588-020-00737-3
Nature Genetics
Nature Genetics, 2020, 52 (12), pp.1364-1372. ⟨10.1038/s41588-020-00737-3⟩
Nature Genetics, Nature Publishing Group, 2020, 52 (12), pp.1364-1372. ⟨10.1038/s41588-020-00737-3⟩
Uggenti, C, Lepelley, A, Depp, M, Badrock, A P, Rodero, M P, El-Daher, M-T, Rice, G I, Dhir, S, Wheeler, A P, Dhir, A, Albawardi, W, Frémond, M-L, Seabra, L, Doig, J, Blair, N, Martin-Niclos, M J, Della Mina, E, Rubio-Roldán, A, García-Pérez, J L, Sproul, D, Rehwinkel, J, Hertzog, J, Boland-Auge, A, Olaso, R, Deleuze, J, Baruteau, J, Brochard, K, Buckley, J, Cavallera, V, Cereda, C, De Waele, L M H, Dobbie, A, Doummar, D, Elmslie, F, Koch-Hogrebe, M, Kumar, R, Lamb, K, Livingston, J H, Majumdar, A, Lorenço, C M, Orcesi, S, Peudenier, S, Rostasy, K, Salmon, C A, Scott, C, Tonduti, D, Touati, G, Valente, M, Van Der Linden Jr, H, Van Esch, H, Vermelle, M, Webb, K, Jackson, A P, Reijns, M A M, Gilbert, N & Crow, Y J 2020, ' cGAS-mediated induction of type I interferon due to inborn errors of histone pre-mRNA processing ', Nature Genetics, vol. 52, no. 12, pp. 1364-1372 . https://doi.org/10.1038/s41588-020-00737-3

International audience; Inappropriate stimulation or defective negative regulation of the type I interferon response can lead to autoinflammation. In genetically uncharacterized cases of the type I interferonopathy Aicardi-Goutières syndrome, we ide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ff60c1ad94564d27eaeaacc887a26e2
https://www.research.manchester.ac.uk/portal/en/publications/cgasmediated-induction-of-type-i-interferon-due-to-inborn-errors-of-histone-premrna-processing(2af4767a-21e6-4a78-93d2-f68838fee8a8).html

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