Zobrazeno 1 - 8 of 8 pro vyhledávání: '"A. Ronald Filon"'
1
Impaired DNA repair capacity in skin fibroblasts from various hereditary cancer-prone syndromes
Autor: Adaya Palam T Natarajan, Caro M. Meijers, Ronald Filon, P. J. Abrahams, Fré Arwert, Ada Houweling, Carrol Terleth, Herbert M. Pinedo, Firouz Darroudi, Paulien D. M. Cornelissen-Steijger, Albert A. van Zeeland, Alex J. van der Eb, Leon H.F. Mullenders, Nicolaas G. J. Jaspers
Publikováno v: Mutation Research, 407(2), 189-201
Host-cell reactivation (HCR) of UV-C-irradiated herpes simplex virus type 1 (HSV-1) has been determined in skin fibroblasts from the following hereditary cancer-prone syndromes: aniridia (AN), dysplastic nevus syndrome (DNS), Von Hippel-Lindau syndro
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::706927b25bb69e6cc01476b84c94873e
https://doi.org/10.1016/S0921-8777(98)00009-3
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2
Enhanced Nucleotide Excision Repair in Human Fibroblasts Pre-exposed to Ionizing Radiation
Autor: Jos C. S. Kleinjans, Albert A. van Zeeland, Alex Pines, Alfred Ronald Filon, Patricia Cramers, Leon H.F. Mullenders
Publikováno v: Photochemistry and Photobiology, 88(1), 147-153. Wiley-Blackwell
Photochemistry and Photobiology, 88(1), 147-153
Cellular protection against deleterious effects of DNA damaging agents requires an intricate network of defense mechanisms known as the DNA damage response (DDR). Ionizing radiation (IR) mediated activation of the DDR induces a transcriptional upregu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1d6ef875bd5986e3e7f913531f284e2
https://hdl.handle.net/1887/98000
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3
Impaired repair of ionizing radiation-induced DNA damage in Cockayne syndrome cells
Autor: Albert A. van Zeeland, Patricia Cramers, Susy J Santos, Esther E. Verhoeven, Leon H.F. Mullenders, A. Ronald Filon, Jos C. S. Kleinjans, Davy A. P. Rockx, Anneke A. van der Leer
Publikováno v: Radiation Research, 175(4), 432-443. Radiation Research Society
Radiation Research, 175(4), 432-443
Radiation Research
Cramers, P., Verhoeven, E. E., Filon, A. R., Rockx, D. A. P., Santos, S. J., van der Leer, A. A., Kleinjans, J. C. S., van Zeeland, A. A. and Mullenders, L. H. F. Impaired Repair of Ionizing Radiation-Induced DNA Damage in Cockayne Syndrome Cells. Ra
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46ffe4b60a67bb7db28742d50559a7c6
https://pubmed.ncbi.nlm.nih.gov/21299404
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4
Pyrimidine Dimer Induction and Repair in Cultured Human Skin Keratinocytes or Melanocytes After Irradiation with Monochromatic Ultraviolet Radiation
Autor: Albert A. Schothorst, Ludo M. Evers, Albert A. van Zeeland, Käthe C. Noz, Ronald Filon
Publikováno v: Journal of Investigative Dermatology. 96(6):916-920
We compared the susceptibilities of cultured melanocytes and keratinocytes to dimer induction in DNA by monochromatic ultraviolet (UV) radiation. Keratinocytes as well as melanocytes were derived from human foreskin, grown as a monolayer in petri dis
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c665f98b44e7f13e419c68280058a593
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5
Lack of transcription-coupled repair of acetylaminofluorene DNA adducts in human fibroblasts contrasts their efficient inhibition of transcription
Autor: Ronald Filon, Leon H.F. Mullenders, Anton J.L. de Groot, Albert A. van Zeeland, Michiel F. van Oosterwijk
Publikováno v: The Journal of biological chemistry. 273(22)
The N-(deoxyguanosine-8-yl)-2-acetylaminofluorene (dG-C8-AAF) lesion is among the most helix distorting DNA lesions. In normal fibroblasts dG-C8-AAF is repaired rapidly in transcriptionally active genes, but without strand specificity, indicating tha
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b19ee13db7a299073352338bb4351ea
https://pubmed.ncbi.nlm.nih.gov/9593697
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6
The sensitivity of human fibroblasts to N-acetoxy-2-acetylaminofluorene is determined by the extent of transcription-coupled repair, and/or their capability to counteract RNA synthesis inhibition
Autor: Albert A. van Zeeland, Ronald Filon, Leon H.F. Mullenders, Michiel F. van Oosterwijk, Wouter Kalle
Nucleotide excision repair (NER) mechanism is the major pathway responsible for the removal of a large variety of bulky lesions from the genome. Two different NER subpathways have been identified, i.e. the transcription-coupled and the global genome
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12ce49eda696ba9315116969856817eb
https://europepmc.org/articles/PMC146299/
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7
The sensitivity of Cockayne's syndrome cells to DNA-damaging agents is not due to defective transcription-coupled repair of active genes
Autor: Ronald Filon, M. F. Van Oosterwijk, Leon H.F. Mullenders, A.A. van Zeeland, A. Versteeg
Publikováno v: Molecular and cellular biology. 16(8)
Two of the hallmarks of Cockayne's syndrome (CS) are the hypersensitivity of cells to UV light and the lack of recovery of the ability to synthesize RNA following exposure of cells to UV light, in spite of the normal repair capacity at the overall ge
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86e9e003458cceca85a53f132c4dd3c5
https://pubmed.ncbi.nlm.nih.gov/8754844
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