A Bayesian model to analyse the association of comorbidities with biosimilar treatment retention in a non-medical switch scenario in patients with inflammatory rheumatic musculoskeletal diseases

Autor: Imke Redeker, Stefan Moustakis, Styliani Tsiami, Xenofon Baraliakos, David Kiefer, Ioana Andreica, Björn Buehring, Jürgen Braun, Uta Kiltz

Publikováno v: Arthritis Research & Therapy, Vol 26, Iss 1, Pp 1-9 (2024)

Abstract Objectives To analyse clinical outcomes of a non-medical switch from originator adalimumab (ADA) to its ABP501 biosimilar (ABP) over 6 months in patients with inflammatory rheumatic musculoskeletal diseases (RMD) in relation to comorbidity a

Externí odkaz: https://doaj.org/article/cf3e905d66dc43ab9d73e8117886d4a6

Acoustically shaped DNA-programmable materials

Autor: Z. A. Arnon, S. Piperno, D. C. Redeker, E. Randall, A. V. Tkachenko, H. Shpaisman, O. Gang

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-8 (2024)

Abstract Recent advances in DNA nanotechnology allow for the assembly of nanocomponents with nanoscale precision, leading to the emergence of DNA-based material fabrication approaches. Yet, transferring these nano- and micron-scale structural arrange

Externí odkaz: https://doaj.org/article/40b4cce0d91649feba0fc4300399d9d7

Huntingtin lowering impairs the maturation and synchronized synaptic activity of human cortical neuronal networks derived from induced pluripotent stem cells

Autor: Mathilde Louçã, Donya El Akrouti, Aude Lemesle, Morgane Louessard, Noëlle Dufour, Chloé Baroin, Aurore de la Fouchardière, Laurent Cotter, Hélène Jean-Jacques, Virginie Redeker, Anselme L. Perrier

Publikováno v: Neurobiology of Disease, Vol 200, Iss , Pp 106630- (2024)

Despite growing descriptions of wild-type Huntingtin (wt-HTT) roles in both adult brain function and, more recently, development, several clinical trials are exploring HTT-lowering approaches that target both wt-HTT and the mutant isoform (mut-HTT) r

Externí odkaz: https://doaj.org/article/014f66c687ef4b789460f73ea00cc84e

Search for the Pair Production of Dark Particles $X$ with $K_L^0 \to XX$, $X \to \gamma\gamma$

Autor: Lin, C., Ahn, J. K., Choi, J. M., Farrington, M. S., Gonzalez, M., Grethen, N., Hsiung, Y. B., Inagaki, T., Kamiji, I., Kim, E. J., Kim, J. L., Kim, H. M., Kawata, K., Kitagawa, A., Komatsubara, T. K., Kotera, K., Lee, S. K., Lee, J. W., Lim, G. Y., Luo, Y., Matsumura, T., Nakagiri, K., Nanjo, H., Nomura, T., Ono, K., Redeker, J. C., Sato, T., Sasse, V., Shibata, T., Shimizu, N., Shinkawa, T., Shinohara, S., Shiomi, K., Shiraishi, R., Suzuki, S., Tajima, Y., Tung, Y. -C., Wah, Y. W., Watanabe, H., Wu, T., Yamanaka, T., Yoshida, H. Y.

We present the first search for the pair production of dark particles $X$ via $K_L^0\to XX$ with $X$ decaying into two photons using the data collected by the KOTO experiment. No signal was observed in the mass range of 40 - 110 MeV/c$^2$ and 210 - 2

Externí odkaz: http://arxiv.org/abs/2209.11019

Prenatal cell-free DNA testing of women with pregnancy-associated cancer: a retrospective cross-sectional study

Autor: Sistermans, E.A., Henneman, L., Polstra, A., Voorhoeve, E., Zelderen-Bohla, S.L., Boon, E.M.J., Lombardi, M.P.R., Louwerens-Zintel, C., Smit, M., van Maarle, M.C., Tan-Sindhunata, M.B., van der Meij, K., Meij, H., Bax, C., Pajkrt, E., Linskens, I.H., Martin, L., Gitsels-van der Wal, J.T., Galjaard, R.J.H., Van Opstal, D., Srebniak, M.I., Jehee, F.M. Sarquis, Hollink, I.H.I.M., Sleutels, F., de Valk, W., Deelen, W.H., Joosten, A.M.S., Diderich, K.E.M., Redeker, M.E., Go, A.T.J.I., Knapen, M.F.C.M., Galjaard, S., Prinsen, A.K.E., Braat, A.P.G., Macville, M.V.E., Stevens, S.J.C., van der Wijngaard, A., Houben, L.H., van Esch-Lennarts, M.A.A., Hamers, L., Jetten, A.G.P., Ghesquiere, S.A.I., Koning, B. de, ZamaniEsteki, M., Heesterbeek, C.J., de Die-Smulders, C.E.M., Brunner, H., Pieters, M.J., Coumans, A.B.C., Smeets, D.F.C.M., Faas, B.H.W., Westra, D., Weiss, M.M., Derks-Prinsen, I., Feenstra, I., van Rij, M., Sikkel, E., Hoffer, M.J.V., Hollander, N.S. den, Verweij, E.J.T., Haak, M.C., Suijkerbuijk, R.F., Sikkema-Raddatz, B., van Langen, I.M., Bouman, K., Duin, L.K., Schuring-Blom, G.H., Lichtenbelt, K.D., Bekker, M.N., van der Ven, A.J.E.M., van Vliet-Lachotzki, E., Pot, J., van ‘t Padje, S., Bakker, I.M.C., Bradley, E.J., Heesterbeek, Catharina J., Tjan-Heijnen, Vivianne C.G., Heimovaara, Joosje H., Lenaerts, Liesbeth, Lok, Christianne, Vriens, Ingeborg J.H., Van Opstal, Diane, Boon, Elles M.J., Sie, Daoud, de Die-Smulders, Christine E.M., Amant, Frédéric, Macville, Merryn V.E.

Publikováno v: In The Lancet Regional Health - Europe October 2024 45