Zobrazeno 1 - 10
of 243
pro vyhledávání: '"A. R. Venkitaraman"'
Autor:
Maryam Ghaderi Najafabadi, G. Kenneth Gray, Li Ren Kong, Komal Gupta, David Perera, Huw Naylor, Joan S. Brugge, Ashok R. Venkitaraman, Mona Shehata
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Germline BRCA2 mutation carriers frequently develop luminal-like breast cancers, but it remains unclear how BRCA2 mutations affect mammary epithelial subpopulations. Here, we report that monoallelic Brca2 mut/WT mammary organoids subjected t
Externí odkaz:
https://doaj.org/article/f836acac45844291bd635b3b1255cb55
Autor:
Teresa Lai Fong Ho, May Yin Lee, Hui Chin Goh, Germaine Yi Ning Ng, Jane Jia Hui Lee, Srinivasaraghavan Kannan, Yan Ting Lim, Tianyun Zhao, Edwin Kok Hao Lim, Cheryl Zi Jin Phua, Yi Fei Lee, Rebecca Yi Xuan Lim, Perry Jun Hao Ng, Ju Yuan, Dedrick Kok Hong Chan, Bettina Lieske, Choon Seng Chong, Kuok Chung Lee, Jeffrey Lum, Wai Kit Cheong, Khay Guan Yeoh, Ker Kan Tan, Radoslaw M. Sobota, Chandra S. Verma, David P. Lane, Wai Leong Tam, Ashok R. Venkitaraman
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Here the authors identify distinct mechanisms by which domain-specific p53 mutations activate cancer cell growth via the epidermal growth factor receptor (EGFR). These mechanisms affect sensitivity to EGFR inhibitors, opening avenues for targeted the
Externí odkaz:
https://doaj.org/article/887b89f317fb487d8e09152d6d299ac4
Autor:
P. Hall, S. Howell, R. Venkitaraman, A. Thomson, F. Raja, J. King, C. Michie, S. Khan, A.M. Brunt, D. Gahir, K. McAdam, J. Cooner, N. Kane
Publikováno v:
Breast, Vol 68, Iss , Pp S47- (2023)
Externí odkaz:
https://doaj.org/article/489ccd2539a74adfa763a4619d25e655
Autor:
Xavier Renaudin, Ashok R. Venkitaraman
Publikováno v:
Molecular & Cellular Oncology, Vol 8, Iss 6 (2021)
How oxidative stress promotes aging-related human diseases like cancer and neurodegeneration remains unclear. Here, we discuss the origins and implications of an oxidative-stress response recently reported to destabilize the mitochondrial (mt) genome
Externí odkaz:
https://doaj.org/article/aa278cd81d2f4f9580ced76d8c078953
Autor:
David J. Huggins, Bryn S. Hardwick, Pooja Sharma, Amy Emery, Luca Laraia, Fengzhi Zhang, Ana J. Narvaez, Meredith Roberts-Thomson, Alex T. Crooks, Robert G. Boyle, Richard Boyce, David W. Walker, Natalia Mateu, Grahame J. McKenzie, David R. Spring, Ashok R. Venkitaraman
Publikováno v:
ACS Omega, Vol 5, Iss 1, Pp 822-831 (2019)
Externí odkaz:
https://doaj.org/article/3fe07deb35644870ad3f7fc29a93ca5e
Publikováno v:
Frontiers in Physics, Vol 9 (2021)
Revealing mechanisms underpinning cell function requires understanding the relationship between different biochemical reactions in living cells. However, our capabilities to monitor more than two biochemical reactions in living cells are limited. The
Externí odkaz:
https://doaj.org/article/2faad21430234a5091ee09a7acfd498a
Publikováno v:
Cell Reports, Vol 30, Iss 7, Pp 2083-2093.e5 (2020)
Summary: Cell-autonomous changes in p53 expression govern the duration and outcome of cell-cycle arrest at the G2 checkpoint for DNA damage. Here, we report that mitogen-activated protein kinase (MAPK) signaling integrates extracellular cues with p53
Externí odkaz:
https://doaj.org/article/46455d6ff1ec455d950a7f11e7450dd6
Publikováno v:
Cell Reports, Vol 22, Iss 4, Pp 1031-1039 (2018)
The controlled release of RNA polymerase II (RNAPII) from promoter-proximal pausing (PPP) sites is critical for transcription elongation in metazoans. We show that the human tumor suppressor BRCA2 interacts with RNAPII to regulate PPP release, thereb
Externí odkaz:
https://doaj.org/article/5b8b19739e6a4eed83692d2f8b20d1f4
Autor:
Yansheng Liu, Mar Gonzàlez-Porta, Sergio Santos, Alvis Brazma, John C. Marioni, Ruedi Aebersold, Ashok R. Venkitaraman, Vihandha O. Wickramasinghe
Publikováno v:
Cell Reports, Vol 20, Iss 5, Pp 1229-1241 (2017)
Summary: Alternative splicing is a critical determinant of genome complexity and, by implication, is assumed to engender proteomic diversity. This notion has not been experimentally tested in a targeted, quantitative manner. Here, we have developed a
Externí odkaz:
https://doaj.org/article/55c48f246f2a422591a9183a112fe3fe
Autor:
Moschetti, Tommaso, Sharpe, Timothy, Fischer, Gerhard, Marsh, May E., Ng, Hong Kin, Morgan, Matthew, Scott, Duncan E., Blundell, Tom L., R. Venkitaraman, Ashok, Skidmore, John, Abell, Chris, Hyvönen, Marko
Publikováno v:
In Journal of Molecular Biology 20 November 2016 428(23):4589-4607